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This paper describes a human-centered exploration environment, which incorporates a coordinated suite of computational and visualization methods to explore high-dimensional data for uncovering patterns in multivariate spaces. Specifically, it includes: (1) an interactive feature selection method for identifying potentially interesting, multidimensional subspaces from a high-dimensional data space, (2) an interactive, hierarchical clustering method for searching multivariate clusters of arbitrary shape, and (3) a suite of coordinated visualization and computational components centered around the above two methods to facilitate a human-led exploration. The implemented system is used to analyze a cancer dataset and shows that it is efficient and effective for discovering unknown and unexpected multivariate patterns from high-dimensional data.<\/jats:p>","DOI":"10.1057\/palgrave.ivs.9500053","type":"journal-article","created":{"date-parts":[[2003,12,17]],"date-time":"2003-12-17T04:12:45Z","timestamp":1071634365000},"page":"232-246","source":"Crossref","is-referenced-by-count":74,"title":["Coordinating Computational and Visual Approaches for Interactive Feature Selection and Multivariate Clustering"],"prefix":"10.1177","volume":"2","author":[{"given":"Diansheng","family":"Guo","sequence":"first","affiliation":[{"name":"GeoVISTA Center & Department of Geography, The Pennsylvania State University, University Park, PA, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2003,12,1]]},"reference":[{"key":"bibr1-palgrave.ivs.9500053","doi-asserted-by":"publisher","DOI":"10.1145\/276304.276314"},{"key":"bibr2-palgrave.ivs.9500053","doi-asserted-by":"publisher","DOI":"10.1145\/564691.564739"},{"key":"bibr3-palgrave.ivs.9500053","doi-asserted-by":"publisher","DOI":"10.1145\/312129.312199"},{"key":"bibr4-palgrave.ivs.9500053","first-page":"1","volume-title":"Advances in Knowledge Discovery","author":"Fayyad U","year":"1996"},{"key":"bibr5-palgrave.ivs.9500053","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-5689-3"},{"key":"bibr6-palgrave.ivs.9500053","unstructured":"Dy JG, Brodley CE. 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