{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T18:41:53Z","timestamp":1773081713158,"version":"3.50.1"},"reference-count":44,"publisher":"AIP Publishing","issue":"1","content-domain":{"domain":["pubs.aip.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1995,3,1]]},"abstract":"<jats:p>In many biological systems, information is transferred by hormonal ligands, and it is assumed that these hormonal signals encode developmental and regulatory programs in mammalian organisms. In contrast to the dogma of endocrine homeostasis, it could be shown that the biological information in hormonal networks is not only present as a constant hormone concentration in the circulation pool. Recently, it has become apparent that hormone pulses contribute to this hormonal pool, which modulates the responsiveness of receptors within the cell membrane by regulation of the receptor synthesis, movement within the membrane layer, coupling to signal transduction proteins and internalization. Phase space analysis of dynamic parathyroid hormone (PTH) secretion allowed the definition of a (in comparison to normal subjects) relatively quiet \u2018\u2018low dynamic\u2019\u2019 secretory pattern in osteoporosis, and a \u2018\u2018high dynamic\u2019\u2019 state in hyperparathyroidism. We now investigate whether this pulsatile secretion of PTH in healthy men exhibits characteristics of nonlinear determinism. Our findings suggest that this is conceivable, although on the basis of presently available data and techniques, no proof can be established. Nevertheless, pulsatile secretion of PTH might be a first example of nonlinear deterministic dynamics in an apparently irregular hormonal rhythm in human physiology.<\/jats:p>","DOI":"10.1063\/1.166089","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T12:02:25Z","timestamp":1027684945000},"page":"76-81","update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":11,"title":["Nonlinear dynamics in pulsatile secretion of parathyroid hormone in normal human subjects"],"prefix":"10.1063","volume":"5","author":[{"given":"Klaus","family":"Prank","sequence":"first","affiliation":[{"name":"Abteilung Klinische Endokrinologie, Medizinische Hochschule Hannover, Konstanty-Gutschow-Str. 8, D-30625 Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heio","family":"Harms","sequence":"additional","affiliation":[{"name":"Abteilung Klinische Endokrinologie, Medizinische Hochschule Hannover, Konstanty-Gutschow-Str. 8, D-30625 Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Brabant","sequence":"additional","affiliation":[{"name":"Abteilung Klinische Endokrinologie, Medizinische Hochschule Hannover, Konstanty-Gutschow-Str. 8, D-30625 Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf-Dieter","family":"Hesch","sequence":"additional","affiliation":[{"name":"Abteilung Klinische Endokrinologie, Medizinische Hochschule Hannover, Konstanty-Gutschow-Str. 8, D-30625 Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"D\u00e4mmig","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Quantenoptik, Universit\u00e4t Hannover, Welfengarten 1, D-30167 Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fedor","family":"Mitschke","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Quantenoptik, Universit\u00e4t Hannover, Welfengarten 1, D-30167 Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"317","reference":[{"key":"2024020122254006300_r1"},{"key":"2024020122254006300_r2"},{"key":"2024020122254006300_r3","first-page":"9","article-title":"Nonlinear dynamics, chaos, and complex cardiac arrhythmias","volume":"413","year":"1987","journal-title":"Philos. 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