{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T04:17:04Z","timestamp":1759033024247},"reference-count":3,"publisher":"AIP Publishing","issue":"5","content-domain":{"domain":["pubs.aip.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1974,5,1]]},"abstract":"<jats:p>The construction of a voltage clamp with discontinuous feedback is described. Its main feature is a pulsed membrane current with an amplitude proportional to the voltage error, which is determined by integration in the pulse intervals. A current pulse of 8 \u03bcsec length repeating every 24 \u03bcsec is used. Gain switching assures a fast response to large errors, as well as high steady state accuracy. Membrane voltage changes by 150 mV in 8 \u03bcsec to 1% of the final value. 50 \u03bcsec after such a step, a change of resistive membrane current can be read reliably. Performance is demonstrated with equivalent networks of biological membranes and with applications to black lipid membranes and epithelial membranes.<\/jats:p>","DOI":"10.1063\/1.1686708","type":"journal-article","created":{"date-parts":[[2004,2,10]],"date-time":"2004-02-10T18:20:33Z","timestamp":1076437233000},"page":"656-661","update-policy":"http:\/\/dx.doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":34,"title":["Design of a fast voltage clamp for biological membranes, using discontinuous feedback"],"prefix":"10.1063","volume":"45","author":[{"given":"R.","family":"Brennecke","sequence":"first","affiliation":[{"name":"Abteilung f\u00fcr Membranforschung an Epithelien, 2nd Dept. of Physiology, 665 Homburg (Saar), West Germany"}]},{"given":"B.","family":"Lindemann","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr Membranforschung an Epithelien, 2nd Dept. of Physiology, 665 Homburg (Saar), West Germany"}]}],"member":"317","reference":[{"key":"2024021110503900200_r1","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1063\/1.1686583","volume":"45","year":"1974","journal-title":"Rev. Sci. Instrum."},{"key":"2024021110503900200_r2","first-page":"1","volume":"374","year":"1974","journal-title":"Pfl\u00fcgers Arch."},{"key":"2024021110503900200_r3","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1748-1716.1971.tb04910.x","volume":"81","year":"1971","journal-title":"Acta Physiol. Scand."}],"container-title":["Review of Scientific Instruments"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.aip.org\/aip\/rsi\/article-pdf\/45\/5\/656\/19099311\/656_1_online.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.aip.org\/aip\/rsi\/article-pdf\/45\/5\/656\/19099311\/656_1_online.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,11]],"date-time":"2024-02-11T10:50:45Z","timestamp":1707648645000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.aip.org\/rsi\/article\/45\/5\/656\/437732\/Design-of-a-fast-voltage-clamp-for-biological"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,5,1]]},"references-count":3,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1974,5,1]]}},"URL":"https:\/\/doi.org\/10.1063\/1.1686708","relation":{},"ISSN":["0034-6748","1089-7623"],"issn-type":[{"value":"0034-6748","type":"print"},{"value":"1089-7623","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1974,5]]},"published":{"date-parts":[[1974,5,1]]}}}