{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T06:45:50Z","timestamp":1764053150349,"version":"3.41.2"},"reference-count":28,"publisher":"AIP Publishing","issue":"4","content-domain":{"domain":["pubs.aip.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2007,4,1]]},"abstract":"<jats:p>We have examined coating (PbMg1\u22153Nb2\u22153O3)0.63\u2013(PbTiO3)0.37 (PMN-PT)\/tin and lead zirconate titanate (PZT)\/glass piezoelectric microcantilever sensor (PEMS) with 3-mercaptopropyl-trimethoxysilane (MPS) by a simple solution method to electrically insulate the PEMS for in-water applications. In contrast to earlier methytrimethoxysilane insulation coating, the MPS coating also facilitated receptor immobilization on the sensor surface via bonding of its sulhydryl group to a bifunctional linker, sulfosuccinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate. We showed that a MPS coating of 21nm in thickness is sufficient to electrically insulate and provide immobilization surface to the PEMS for in-liquid electrical self-excitation and self-sensing. The in-phosphate buffered saline solution resonance spectra were stable with Q values ranging from 41 to 55. The mass detection sensitivities were determined to be 5\u00d710\u221211 and 8\u00d710\u221212g\u2215Hz for the MPS-insulated PZT-glass and PMN-PT\/tin PEMSs, respectively.<\/jats:p>","DOI":"10.1063\/1.2727466","type":"journal-article","created":{"date-parts":[[2007,4,24]],"date-time":"2007-04-24T17:51:56Z","timestamp":1177437116000},"update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":22,"title":["3-mercaptopropyltrimethoxysilane as insulating coating and surface for protein immobilization for piezoelectric microcantilever sensors"],"prefix":"10.1063","volume":"78","author":[{"given":"Joseph A.","family":"Capobianco","sequence":"first","affiliation":[{"name":"Drexel University Department of Materials Science and Engineering, , Philadelphia, Pennsylvania 19104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan Y.","family":"Shih","sequence":"additional","affiliation":[{"name":"Drexel University School of Biomedical Engineering, Science, and Health Systems, , Philadelphia, Pennsylvania 19104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Heng","family":"Shih","sequence":"additional","affiliation":[{"name":"Drexel University Department of Materials Science and Engineering, , Philadelphia, Pennsylvania 19104"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"317","published-online":{"date-parts":[[2007,4,23]]},"reference":[{"key":"2023070317475846800_c1","doi-asserted-by":"publisher","first-page":"023506","DOI":"10.1063\/1.2219994","volume":"89","year":"2006","journal-title":"Appl. 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