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A 22 keV monochromatic x-ray beam is prepared using a mismatched, two-crystal monochromator; a silicon analyzer crystal is placed in a parallel crystal geometry with the monochromator allowing both diffraction-enhanced imaging and multiple-imaging radiography to be performed. The DEXI instrument was found to have an experimentally determined spatial resolution of 160\u00b17\u2002\u03bcm in the horizontal direction and 153\u00b17\u2002\u03bcm in the vertical direction. As applied to biomedical imaging, the DEXI instrument can detect soft tissues, such as tendons and other connective tissues, that are normally difficult or impossible to image via conventional x-ray techniques.<\/jats:p>","DOI":"10.1063\/1.3213621","type":"journal-article","created":{"date-parts":[[2009,9,14]],"date-time":"2009-09-14T22:39:02Z","timestamp":1252967942000},"update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":43,"title":["The design and application of an in-laboratory diffraction-enhanced x-ray imaging instrument"],"prefix":"10.1063","volume":"80","author":[{"given":"Ivan","family":"Nesch","sequence":"first","affiliation":[{"name":"Nesch 1 , LLC 9800 Connecticut Drive, Crown Point, Indiana 46307, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel P.","family":"Fogarty","sequence":"additional","affiliation":[{"name":"Nesch 1 , LLC 9800 Connecticut Drive, Crown Point, Indiana 46307, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tochko","family":"Tzvetkov","sequence":"additional","affiliation":[{"name":"Nesch 1 , LLC 9800 Connecticut Drive, Crown Point, Indiana 46307, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Reinhart","sequence":"additional","affiliation":[{"name":"Nesch 1 , LLC 9800 Connecticut Drive, Crown Point, Indiana 46307, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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