{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:49:25Z","timestamp":1788871765193,"version":"build-2803163510"},"reference-count":58,"publisher":"AIP Publishing","issue":"1","funder":[{"DOI":"10.13039\/100000006","name":"Office of Naval Research","doi-asserted-by":"publisher","award":["N00014-10-1-0072 (HP)"],"award-info":[{"award-number":["N00014-10-1-0072 (HP)"]}],"id":[{"id":"10.13039\/100000006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["SBE-0542013"],"award-info":[{"award-number":["SBE-0542013"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["2 R01 NS036449 (HP)"],"award-info":[{"award-number":["2 R01 NS036449 (HP)"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pubs.aip.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,3,1]]},"abstract":"<jats:p>Parkinson\u2019s disease is a degenerative condition whose severity is assessed by clinical observations of motor behaviors. These are performed by a neurological specialist through subjective ratings of a variety of movements including 10-s bouts of repetitive finger-tapping movements. We present here an algorithmic rating of these movements which may be beneficial for uniformly assessing the progression of the disease. Finger-tapping movements were digitally recorded from Parkinson\u2019s patients and controls, obtaining one time series for every 10 s bout. A nonlinear delay differential equation, whose structure was selected using a genetic algorithm, was fitted to each time series and its coefficients were used as a six-dimensional numerical descriptor. The algorithm was applied to time-series from two different groups of Parkinson\u2019s patients and controls. The algorithmic scores compared favorably with the unified Parkinson\u2019s disease rating scale scores, at least when the latter adequately matched with ratings from the Hoehn and Yahr scale. Moreover, when the two sets of mean scores for all patients are compared, there is a strong (r\u2009=\u20090.785) and significant (p&amp;lt;0.0015) correlation between them.<\/jats:p>","DOI":"10.1063\/1.3683444","type":"journal-article","created":{"date-parts":[[2012,2,16]],"date-time":"2012-02-16T19:39:33Z","timestamp":1329421173000},"update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":31,"title":["Finger tapping movements of Parkinson\u2019s disease patients automatically rated using nonlinear delay differential equations"],"prefix":"10.1063","volume":"22","author":[{"given":"C.","family":"Lainscsek","sequence":"first","affiliation":[{"name":"University of California at San Diego 1 Institute for Neural Computation, , La Jolla, California 92093-0523, USA"},{"name":"The Salk Institute for Biological Studies 2 Computational Neurobiology Laboratory, , La Jolla, California 92037, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Rowat","sequence":"additional","affiliation":[{"name":"University of California at San Diego 1 Institute for Neural Computation, , La Jolla, California 92093-0523, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Schettino","sequence":"additional","affiliation":[{"name":"Lafayette College Easten 3 Department of Psychology, , Pennsylvania 18042, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Lee","sequence":"additional","affiliation":[{"name":"University of California at San Diego 1 Institute for Neural Computation, , La Jolla, California 92093-0523, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Song","sequence":"additional","affiliation":[{"name":"University of California at San Diego 4 Department of Neurosciences, , La Jolla, California 92093-9127, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Letellier","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Rouen 5 CORIA UMR 6614, , BP 12, F-76801 Saint-Etienne du Rouvray cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Poizner","sequence":"additional","affiliation":[{"name":"University of California at San Diego 1 Institute for Neural Computation, , La Jolla, California 92093-0523, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"317","published-online":{"date-parts":[[2012,2,16]]},"reference":[{"issue":"12","key":"2023062418425425200_c1","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1016\/S1474-4422(09)70293-5","volume":"8","year":"2009","journal-title":"Lancet Neurol."},{"key":"2023062418425425200_c2","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/j.conb.2006.10.002","volume":"16","year":"2006","journal-title":"Curr. 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