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With large-scale all-atom molecular dynamics simulations, here we show that graphene nanosheets can easily and quickly win a competitive adsorption of human islet amyloid polypeptides (hIAPP22-28) NFGAILS and associated fibrils against cell membrane, due to graphene's unique two-dimensional, highly hydrophobic surface with its all-sp2 hybrid structure. A nanoscale dewetting transition was observed at the interfacial region between the fibril (originally deposited on the membrane) and the graphene nanosheet, which significantly assisted the adsorption of fibrils onto graphene from the membrane. The \u03c0\u2013\u03c0 stacking interaction between Phe23 and graphene played a crucial role, providing the driving force for the adsorption at the graphene surface. This study renders new insight towards the importance of water during the interactions between amyloid peptides, the phospholipidic membrane, and graphene, which might shed some light on future developments of graphene-based nanomedicine for preventing\/curing PCDs like type II diabetes mellitus.<\/jats:p>","DOI":"10.1063\/1.4901113","type":"journal-article","created":{"date-parts":[[2014,11,11]],"date-time":"2014-11-11T01:30:45Z","timestamp":1415669445000},"update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":18,"title":["Dewetting transition assisted clearance of (NFGAILS) amyloid fibrils from cell membranes by graphene"],"prefix":"10.1063","volume":"141","author":[{"given":"Jiajia","family":"Liu","sequence":"first","affiliation":[{"name":"Soochow University 1 Institute of Quantitative Biology and Medicine, SRMP and RAD-X, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, and Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection, , Suzhou 215123, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zaixing","family":"Yang","sequence":"additional","affiliation":[{"name":"Soochow University 1 Institute of Quantitative Biology and Medicine, SRMP and RAD-X, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, and Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection, , Suzhou 215123, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haotian","family":"Li","sequence":"additional","affiliation":[{"name":"Zhejiang University 2 Bio-X Lab, Department of Physics, , Hangzhou 310027, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zonglin","family":"Gu","sequence":"additional","affiliation":[{"name":"Soochow University 1 Institute of Quantitative Biology and Medicine, SRMP and RAD-X, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, and Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection, , Suzhou 215123, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Antonio","family":"Garate","sequence":"additional","affiliation":[{"name":"IBM Thomas J. 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