{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:46:11Z","timestamp":1788871571214,"version":"build-2803163510"},"reference-count":21,"publisher":"AIP Publishing","issue":"1","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["1R15EB013439"],"award-info":[{"award-number":["1R15EB013439"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["pubs.aip.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"<jats:p>Compression therapy has long been a standard treatment for hypertrophic scar prevention. However, due to the lack of objective, quantitative assessments, and measurements of scar severity, as well as the lack of a self-operated, controllable, and precise pressure delivery technique, limited concrete evidence exists, demonstrating compression therapy\u2019s efficacy. We have designed and built an automatic pressure delivery system to apply and maintain constant pressure on scar tissue in an animal model. A force sensor positioned on a compression plate reads the imposed force in real-time and sends the information to a feedback system controlling two position actuators. The actuators move accordingly to maintain a preset value of pressure onto the skin. The system was used in an in vivo model of compression therapy on hypertrophic scars. It was shown that the system was capable of delivering a constant pressure of 30 mmHg on scar wounds for a period of two weeks, and that phenotypic changes were seen in the wounds.<\/jats:p>","DOI":"10.1063\/1.4904842","type":"journal-article","created":{"date-parts":[[2014,12,31]],"date-time":"2014-12-31T13:17:41Z","timestamp":1420031861000},"update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":13,"title":["A portable automatic pressure delivery system for scar compression therapy in large animals"],"prefix":"10.1063","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4810-9454","authenticated-orcid":false,"given":"Pejhman","family":"Ghassemi","sequence":"first","affiliation":[{"name":"The Catholic University of America 1 Department of Electrical Engineering and Computer Science, , 620 Michigan Avenue NE, Washington, DC 20064, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey W.","family":"Shupp","sequence":"additional","affiliation":[{"name":"MedStar Washington Hospital Center 2 The Burn Center, Department of Surgery, , 110 Irving Street NW, Washington, DC 20010, USA"},{"name":"MedStar Health Research Institute 3 The Firefighters\u2019 Burn and Surgical Research Laboratory, , 108 Irving Street NW, Washington, DC 20010, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taryn E.","family":"Travis","sequence":"additional","affiliation":[{"name":"MedStar Health Research Institute 3 The Firefighters\u2019 Burn and Surgical Research Laboratory, , 108 Irving Street NW, Washington, DC 20010, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Gravunder","sequence":"additional","affiliation":[{"name":"The Catholic University of America 4 Department of Biomedical Engineering, , 620 Michigan Avenue NE, Washington, DC 20064, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren T.","family":"Moffatt","sequence":"additional","affiliation":[{"name":"MedStar Health Research Institute 3 The Firefighters\u2019 Burn and Surgical Research Laboratory, , 108 Irving Street NW, Washington, DC 20010, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica C.","family":"Ramella-Roman","sequence":"additional","affiliation":[{"name":"The Catholic University of America 4 Department of Biomedical Engineering, , 620 Michigan Avenue NE, Washington, DC 20064, USA"},{"name":"Florida International University 5 Department of Biomedical Engineering and Herbert Wertheim College of Medicine, , 10555 W. 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