{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T22:13:13Z","timestamp":1769119993995,"version":"3.49.0"},"reference-count":113,"publisher":"AIP Publishing","issue":"4","funder":[{"name":"Cai Yuanpei Exchange Program","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"name":"Carl Trygger's Stiftelse","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"name":"Qian Ren"},{"name":"Region Centre Recherche","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"name":"Vetenskapsradet","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]}],"content-domain":{"domain":["pubs.aip.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,1,28]]},"abstract":"<jats:p>The human islet amyloid polypeptide (hIAPP) co-operates with insulin to maintain glycemic balance. It also constitutes the amyloid plaques that aggregate in the pancreas of type-II diabetic patients. We have performed extensive in silico investigations to analyse the structural landscape of monomeric hIAPP, which is presumed to be intrinsically disordered. For this, we construct from first principles a highly predictive energy function that describes a monomeric hIAPP observed in a nuclear magnetic resonance experiment, as a local energy minimum. We subject our theoretical model of hIAPP to repeated heating and cooling simulations, back and forth between a high temperature regime where the conformation resembles a random walker and a low temperature limit where no thermal motions prevail. We find that the final low temperature conformations display a high level of degeneracy, in a manner which is fully in line with the presumed intrinsically disordered character of hIAPP. In particular, we identify an isolated family of \u03b1-helical conformations that might cause the transition to amyloidosis, by nucleation.<\/jats:p>","DOI":"10.1063\/1.4905586","type":"journal-article","created":{"date-parts":[[2015,1,28]],"date-time":"2015-01-28T18:00:17Z","timestamp":1422468017000},"update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":8,"title":["Aspects of structural landscape of human islet amyloid polypeptide"],"prefix":"10.1063","volume":"142","author":[{"given":"Jianfeng","family":"He","sequence":"first","affiliation":[{"name":"Beijing Institute of Technology 1 School of Physics, , Beijing 100081, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Dai","sequence":"additional","affiliation":[{"name":"Beijing Institute of Technology 1 School of Physics, , Beijing 100081, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Yangtze River Pharmaceutical Group Beijing Haiyan Pharmaceutical Co., Ltd 2 Institute of Biopharmaceutical Research, , Beijing 102206, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xubiao","family":"Peng","sequence":"additional","affiliation":[{"name":"Uppsala University 3 Department of Physics and Astronomy, , P.O. Box 803, S-75108 Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antti J.","family":"Niemi","sequence":"additional","affiliation":[{"name":"Beijing Institute of Technology 1 School of Physics, , Beijing 100081, People\u2019s Republic of China"},{"name":"Uppsala University 3 Department of Physics and Astronomy, , P.O. Box 803, S-75108 Uppsala, Sweden"},{"name":"Universit\u00e9 de Tours 4 Laboratoire de Mathematiques et Physique Theorique CNRS UMR 6083, F\u00e9d\u00e9ration Denis Poisson, , Parc de Grandmont, F37200 Tours, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"317","published-online":{"date-parts":[[2015,1,28]]},"reference":[{"key":"2023073023272647300_c1","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1152\/physrev.00042.2009","volume":"91","year":"2011","journal-title":"Physiol. Rev."},{"key":"2023073023272647300_c2","first-page":"826706","volume":"2013","journal-title":"BioMed Res. Int."},{"key":"2023073023272647300_c3","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1016\/j.febslet.2013.01.046","volume":"587","year":"2013","journal-title":"FEBS Lett."},{"key":"2023073023272647300_c4","doi-asserted-by":"publisher","first-page":"241","DOI":"10.2337\/diabetes.48.2.241","volume":"48","year":"1999","journal-title":"Diabetes"},{"key":"2023073023272647300_c5","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1056\/NEJM200008103430607","volume":"343","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"2023073023272647300_c6","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1146\/annurev.biochem.75.101304.123901","volume":"75","year":"2006","journal-title":"Annu. Rev. Biochem."},{"key":"2023073023272647300_c7","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1210\/er.2007-0037","volume":"29","year":"2008","journal-title":"Endocr. Rev."},{"key":"2023073023272647300_c8","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1038\/368756a0","volume":"368","year":"1994","journal-title":"Nature"},{"key":"2023073023272647300_c9","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/0014-5793(93)81444-5","volume":"323","year":"1993","journal-title":"FEBS Lett."},{"key":"2023073023272647300_c10","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1021\/ar200189b","volume":"45","year":"2012","journal-title":"Acc. Chem. Res."},{"key":"2023073023272647300_c11","doi-asserted-by":"publisher","first-page":"10859","DOI":"10.1002\/anie.201102887","volume":"50","year":"2011","journal-title":"Angew. Chem., Int. Ed."},{"key":"2023073023272647300_c12","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1006\/jmbi.1999.2646","volume":"287","year":"1999","journal-title":"J. Mol. Biol."},{"key":"2023073023272647300_c13","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1146\/annurev.biochem.66.1.385","volume":"66","year":"1997","journal-title":"Annu. Rev. Biochem."},{"key":"2023073023272647300_c14","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1016\/j.jmb.2003.11.048","volume":"335","year":"2004","journal-title":"J. Mol. Biol."},{"key":"2023073023272647300_c15","doi-asserted-by":"publisher","first-page":"48420","DOI":"10.1074\/jbc.M406853200","volume":"279","year":"2004","journal-title":"J. Biol. Chem."},{"key":"2023073023272647300_c16","doi-asserted-by":"publisher","first-page":"12113","DOI":"10.1021\/bi050840w","volume":"44","year":"2005","journal-title":"Biochemistry"},{"key":"2023073023272647300_c17","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.12968\/bjon.2007.16.16.27079","volume":"16","year":"2007","journal-title":"Br. J. Nurs."},{"key":"2023073023272647300_c18","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1038\/nature05695","volume":"447","year":"2007","journal-title":"Nature"},{"key":"2023073023272647300_c19","doi-asserted-by":"publisher","first-page":"13505","DOI":"10.1021\/bi701427q","volume":"46","year":"2007","journal-title":"Biochemistry"},{"key":"2023073023272647300_c20","doi-asserted-by":"publisher","first-page":"12689","DOI":"10.1021\/bi8014357","volume":"47","year":"2008","journal-title":"Biochemistry"},{"key":"2023073023272647300_c21","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1110\/ps.036509.108","volume":"17","year":"2008","journal-title":"Protein Sci."},{"key":"2023073023272647300_c22","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1002\/pro.145","volume":"18","year":"2009","journal-title":"Protein Sci."},{"key":"2023073023272647300_c23","doi-asserted-by":"publisher","first-page":"11982","DOI":"10.1074\/jbc.M809085200","volume":"284","year":"2009","journal-title":"J. Biol. Chem."},{"key":"2023073023272647300_c24","doi-asserted-by":"publisher","first-page":"18283","DOI":"10.1021\/ja903814q","volume":"131","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"2023073023272647300_c25","doi-asserted-by":"publisher","first-page":"2337","DOI":"10.1016\/j.bbamem.2011.06.012","volume":"1808","year":"2011","journal-title":"Biochim. Biophys. Acta, Biomembr."},{"key":"2023073023272647300_c26","doi-asserted-by":"publisher","first-page":"2983","DOI":"10.1021\/ci300300e","volume":"52","year":"2012","journal-title":"J. Chem. Inf. Model."},{"key":"2023073023272647300_c27","doi-asserted-by":"publisher","first-page":"5235","DOI":"10.1074\/jbc.M111.327817","volume":"287","year":"2012","journal-title":"J. Biol. Chem."},{"key":"2023073023272647300_c28","doi-asserted-by":"publisher","first-page":"2781","DOI":"10.1038\/srep02781","volume":"3","year":"2013","journal-title":"Sci. Rep."},{"key":"2023073023272647300_c29","doi-asserted-by":"publisher","first-page":"3339","DOI":"10.1039\/c3cc40383a","volume":"49","year":"2013","journal-title":"Chem. Commun."},{"key":"2023073023272647300_c30","doi-asserted-by":"publisher","first-page":"1864","DOI":"10.1021\/jz5001775","volume":"5","year":"2014","journal-title":"J. Phys. Chem. Lett."},{"key":"2023073023272647300_c31","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/S1093-3263(00)00138-8","volume":"19","year":"2001","journal-title":"J. Mol. Graphics Modell."},{"key":"2023073023272647300_c32","doi-asserted-by":"publisher","first-page":"055102","DOI":"10.1063\/1.4817000","volume":"139","year":"2013","journal-title":"J. Chem. Phys."},{"key":"2023073023272647300_c33","doi-asserted-by":"publisher","first-page":"13991","DOI":"10.1021\/jp308708h","volume":"116","year":"2012","journal-title":"J. Phys. Chem. B"},{"key":"2023073023272647300_c34","doi-asserted-by":"publisher","first-page":"16092","DOI":"10.1021\/ja403147m","volume":"135","year":"2013","journal-title":"J. Am. Chem. Soc."},{"key":"2023073023272647300_c35","doi-asserted-by":"publisher","first-page":"e1003211","DOI":"10.1371\/journal.pcbi.1003211","volume":"9","year":"2013","journal-title":"PLoS Comput. Biol."},{"key":"2023073023272647300_c36","doi-asserted-by":"publisher","first-page":"16066","DOI":"10.1021\/jp409755y","volume":"117","year":"2013","journal-title":"J. Phys. Chem. B"},{"key":"2023073023272647300_c37","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1021\/bi301525e","volume":"52","year":"2013","journal-title":"Biochemistry"},{"key":"2023073023272647300_c38","doi-asserted-by":"publisher","first-page":"e97051","DOI":"10.1371\/journal.pone.0097051","volume":"9","year":"2014","journal-title":"PLoS One"},{"key":"2023073023272647300_c39","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/bs.apcsb.2014.06.006","volume":"96","year":"2014","journal-title":"Adv. Protein Chem. Struct. Biol."},{"key":"2023073023272647300_c40","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1145\/1364782.1364802","volume":"51","year":"2008","journal-title":"Commun. ACM"},{"key":"2023073023272647300_c41","doi-asserted-by":"publisher","first-page":"3787","DOI":"10.1021\/ja209931w","volume":"134","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"2023073023272647300_c42","doi-asserted-by":"publisher","first-page":"5036","DOI":"10.1073\/pnas.87.13.5036","volume":"87","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2023073023272647300_c43","doi-asserted-by":"publisher","first-page":"330","DOI":"10.2337\/diab.42.2.330","volume":"42","year":"1993","journal-title":"Diabetes"},{"key":"2023073023272647300_c44","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1006\/jmbi.1999.3286","volume":"294","year":"1999","journal-title":"J. Mol. Biol."},{"key":"2023073023272647300_c45","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1006\/jmbi.1999.3422","volume":"295","year":"2000","journal-title":"J. Mol. Biol."},{"key":"2023073023272647300_c46","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1006\/jsbi.2000.4268","volume":"130","year":"2000","journal-title":"J. Struct. Biol."},{"key":"2023073023272647300_c47","doi-asserted-by":"publisher","first-page":"34156","DOI":"10.1074\/jbc.M102883200","volume":"276","year":"2001","journal-title":"J. Biol. Chem."},{"key":"2023073023272647300_c48","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1006\/jmbi.2001.4593","volume":"308","year":"2001","journal-title":"J. Mol. Biol."},{"key":"2023073023272647300_c49","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/S0022-2836(02)00164-X","volume":"318","year":"2002","journal-title":"J. Mol. Biol."},{"key":"2023073023272647300_c50","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1016\/S0022-2836(02)00887-2","volume":"322","year":"2002","journal-title":"J. Mol. Biol."},{"key":"2023073023272647300_c51","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/S1047-8477(02)00630-5","volume":"141","year":"2003","journal-title":"J. Struct. Biol."},{"key":"2023073023272647300_c52","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.jmb.2005.02.029","volume":"348","year":"2005","journal-title":"J. Mol. Biol."},{"key":"2023073023272647300_c53","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1142\/S0219720006002004","volume":"4","year":"2006","journal-title":"J. Bioinf. Comput. Biol."},{"key":"2023073023272647300_c54","doi-asserted-by":"publisher","first-page":"2218","DOI":"10.1093\/bioinformatics\/btm325","volume":"23","year":"2007","journal-title":"Bioinformatics"},{"key":"2023073023272647300_c55","doi-asserted-by":"publisher","first-page":"6614","DOI":"10.1073\/pnas.0805957106","volume":"106","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2023073023272647300_c56","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.jmb.2009.07.077","volume":"393","year":"2009","journal-title":"J. Mol. Biol."},{"key":"2023073023272647300_c57","doi-asserted-by":"publisher","first-page":"2948","DOI":"10.1016\/j.bpj.2009.08.041","volume":"97","year":"2009","journal-title":"Biophys. J."},{"key":"2023073023272647300_c58","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.1016\/j.bpj.2013.08.026","volume":"105","year":"2013","journal-title":"Biophys. J."},{"key":"2023073023272647300_c59","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/0167-0115(90)90004-G","volume":"31","year":"1990","journal-title":"Regul. Pept."},{"key":"2023073023272647300_c60","doi-asserted-by":"publisher","first-page":"106004","DOI":"10.1103\/physrevd.67.106004","volume":"67","year":"2003","journal-title":"Phys. Rev. D"},{"key":"2023073023272647300_c61","doi-asserted-by":"publisher","first-page":"021910","DOI":"10.1103\/physreve.82.021910","volume":"82","year":"2010","journal-title":"Phys. Rev. E"},{"key":"2023073023272647300_c62","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1007\/s11232-014-0210-x","volume":"181","year":"2014","journal-title":"Theor. Math. Phys."},{"key":"2023073023272647300_c63","doi-asserted-by":"publisher","first-page":"3892","DOI":"10.1063\/1.1696617","volume":"43","year":"1965","journal-title":"J. Chem. Phys."},{"key":"2023073023272647300_c64","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1103\/PhysicsPhysiqueFizika.2.263","volume":"2","year":"1966","journal-title":"Physics"},{"key":"2023073023272647300_c65","doi-asserted-by":"publisher","first-page":"3174","DOI":"10.1103\/PhysRevB.4.3174","volume":"4","year":"1971","journal-title":"Phys. Rev. B"},{"key":"2023073023272647300_c66","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1103\/RevModPhys.46.597","volume":"46","year":"1974","journal-title":"Rev. Mod. Phys."},{"key":"2023073023272647300_c67","doi-asserted-by":"publisher","first-page":"011916","DOI":"10.1103\/physreve.82.011916","volume":"82","year":"2010","journal-title":"Phys. Rev. E"},{"key":"2023073023272647300_c68","doi-asserted-by":"publisher","first-page":"078102","DOI":"10.1103\/PhysRevLett.106.078102","volume":"106","year":"2011","journal-title":"Phys. Rev. Lett."},{"key":"2023073023272647300_c69","doi-asserted-by":"publisher","first-page":"041907","DOI":"10.1103\/physreve.83.041907","volume":"83","year":"2011","journal-title":"Phys. Rev. E"},{"key":"2023073023272647300_c70","doi-asserted-by":"publisher","first-page":"031906","DOI":"10.1103\/physreve.85.031906","volume":"85","year":"2012","journal-title":"Phys. Rev. E"},{"key":"2023073023272647300_c71","doi-asserted-by":"publisher","first-page":"021923","DOI":"10.1103\/physreve.86.021923","volume":"86","year":"2012","journal-title":"Phys. Rev. E"},{"key":"2023073023272647300_c72","doi-asserted-by":"publisher","first-page":"325103","DOI":"10.1088\/0953-8984\/25\/32\/325103","volume":"25","year":"2013","journal-title":"J. Phys.: Condens. Matter"},{"key":"2023073023272647300_c73","doi-asserted-by":"publisher","first-page":"175101","DOI":"10.1063\/1.4801330","volume":"138","year":"2013","journal-title":"J. Chem. Phys."},{"key":"2023073023272647300_c74","doi-asserted-by":"publisher","first-page":"105011","DOI":"10.1103\/physrevd.87.105011","volume":"87","year":"2013","journal-title":"Phys. Rev. D"},{"key":"2023073023272647300_c75","doi-asserted-by":"publisher","first-page":"025012","DOI":"10.1103\/physrevd.90.025012","volume":"90","year":"2014","journal-title":"Phys. Rev. D"},{"key":"2023073023272647300_c76","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1126\/science.181.4096.223","volume":"181","year":"1973","journal-title":"Science"},{"key":"2023073023272647300_c77","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1146\/annurev.bb.17.060188.002315","volume":"117","year":"1988","journal-title":"Annu. Rev. Biophys. Biophys. Chem."},{"key":"2023073023272647300_c78","doi-asserted-by":"publisher","first-page":"061908","DOI":"10.1103\/physreve.83.061908","volume":"83","year":"2011","journal-title":"Phys. Rev. E"},{"key":"2023073023272647300_c79","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1006\/jmbi.1993.1172","volume":"230","year":"1993","journal-title":"J. Mol. Biol."},{"key":"2023073023272647300_c80","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1006\/jmbi.1993.1170","volume":"230","year":"1993","journal-title":"J. Mol. Biol."},{"key":"2023073023272647300_c81","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1002\/1097-0134(20000815)40:3%3C389::AID-PROT50%3E3.0.CO;2-2","volume":"40","year":"2000","journal-title":"Proteins"},{"key":"2023073023272647300_c82","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/S0959-440X(02)00344-5","volume":"12","year":"2002","journal-title":"Curr. Opin. Struct. Biol."},{"key":"2023073023272647300_c83","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1016\/j.str.2011.03.019","volume":"19","year":"2011","journal-title":"Structure"},{"key":"2023073023272647300_c84","doi-asserted-by":"publisher","first-page":"061909","DOI":"10.1103\/physreve.85.061909","volume":"85","year":"2012","journal-title":"Phys. Rev. E"},{"key":"2023073023272647300_c85","doi-asserted-by":"publisher","first-page":"021904","DOI":"10.1103\/physreve.86.021904","volume":"86","year":"2012","journal-title":"Phys. Rev. E"},{"key":"2023073023272647300_c86","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1016\/s0022-2836(05)80134-2","volume":"247","year":"1995","journal-title":"J. Mol. Biol."},{"key":"2023073023272647300_c87","doi-asserted-by":"publisher","first-page":"D291","DOI":"10.1093\/nar\/gkl959","volume":"35","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"2023073023272647300_c88","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.sbi.2009.02.005","volume":"19","year":"2009","journal-title":"Curr. Opin. Struct. Biol."},{"key":"2023073023272647300_c89","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.sbi.2007.06.001","volume":"17","year":"2007","journal-title":"Curr. Opin. Struct. Biol."},{"key":"2023073023272647300_c90","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1146\/annurev.physchem.58.032806.104614","volume":"58","year":"2007","journal-title":"Annu. Rev. Phys. Chem."},{"key":"2023073023272647300_c91","doi-asserted-by":"publisher","first-page":"2032","DOI":"10.1110\/ps.0386903","volume":"12","year":"2003","journal-title":"Protein Sci."},{"key":"2023073023272647300_c92","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1002\/prot.10286","volume":"50","year":"2003","journal-title":"Proteins"},{"key":"2023073023272647300_c93","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.1002\/jcc.20906","volume":"29","year":"2008","journal-title":"J. Comput. Chem."},{"key":"2023073023272647300_c94","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1002\/prot.22380","volume":"76","year":"2009","journal-title":"Proteins"},{"key":"2023073023272647300_c95","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1002\/prot.22488","volume":"77","year":"2009","journal-title":"Proteins"},{"key":"2023073023272647300_c96","doi-asserted-by":"publisher","first-page":"124115","DOI":"10.1063\/1.4821598","volume":"139","year":"2013","journal-title":"J. Chem. Phys."},{"key":"2023073023272647300_c97","volume-title":"Hamiltonian Methods in the Theory of Solitons","year":"1987"},{"key":"2023073023272647300_c98","volume-title":"Discrete and Continuous Nonlinear Schr\u00f6dinger Systems","year":"2004"},{"key":"2023073023272647300_c99","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1017\/S0022112072002307","volume":"11","year":"1972","journal-title":"J. Fluid Mech."},{"key":"2023073023272647300_c100","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1063\/1.1703954","volume":"4","year":"1963","journal-title":"J. Math. Phys."},{"key":"2023073023272647300_c101","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/0021-9991(75)90060-1","volume":"17","year":"1975","journal-title":"J. Comput. Phys."},{"key":"2023073023272647300_c102","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1007\/BF02101929","volume":"161","year":"1994","journal-title":"Commun. Math. Phys."},{"key":"2023073023272647300_c103","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1007\/BF02101930","volume":"161","year":"1994","journal-title":"Commun. Math. Phys."},{"key":"2023073023272647300_c104","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1111\/j.1432-1033.1990.tb15578.x","volume":"190","year":"1990","journal-title":"Eur. J. Biochem."},{"key":"2023073023272647300_c105","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.bbamem.2004.04.011","volume":"1666","year":"2004","journal-title":"Biochim. Biophys. Acta, Biomembr."},{"key":"2023073023272647300_c106","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.ymeth.2007.01.007","volume":"41","year":"2007","journal-title":"Methods"},{"key":"2023073023272647300_c107","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1016\/j.jmb.2007.11.026","volume":"375","year":"2008","journal-title":"J. Mol. Biol."},{"key":"2023073023272647300_c108","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1002\/bip.10386","volume":"69","year":"2003","journal-title":"Biopolymers"},{"key":"2023073023272647300_c109","doi-asserted-by":"publisher","first-page":"2061","DOI":"10.1021\/bi101936c","volume":"50","year":"2011","journal-title":"Biochemistry"},{"key":"2023073023272647300_c110","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1002\/prot.24229","volume":"81","year":"2013","journal-title":"Proteins"},{"key":"2023073023272647300_c111","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1107\/s0907444909042073","volume":"66","year":"2010","journal-title":"Acta Crystallogr., Sect. D: Biol. Crystallogr."},{"key":"2023073023272647300_c112","doi-asserted-by":"publisher","first-page":"035101","DOI":"10.1063\/1.4734019","volume":"137","year":"2012","journal-title":"J. Chem. Phys."},{"key":"2023073023272647300_c113","doi-asserted-by":"publisher","first-page":"11385","DOI":"10.1021\/jp803896b","volume":"112","year":"2008","journal-title":"J. Phys. Chem. B"}],"container-title":["The Journal of Chemical Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.aip.org\/aip\/jcp\/article-pdf\/doi\/10.1063\/1.4905586\/15493285\/045102_1_online.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.aip.org\/aip\/jcp\/article-pdf\/doi\/10.1063\/1.4905586\/15493285\/045102_1_online.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,30]],"date-time":"2023-07-30T23:27:51Z","timestamp":1690759671000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.aip.org\/jcp\/article\/142\/4\/045102\/902005\/Aspects-of-structural-landscape-of-human-islet"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,28]]},"references-count":113,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,1,28]]}},"URL":"https:\/\/doi.org\/10.1063\/1.4905586","relation":{},"ISSN":["0021-9606","1089-7690"],"issn-type":[{"value":"0021-9606","type":"print"},{"value":"1089-7690","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2015,1,28]]},"published":{"date-parts":[[2015,1,28]]},"article-number":"045102"}}