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Because of the geometry of membrane stacks deposited on planar substrates, the scattered intensity profile was analyzed in a 2D reciprocal space map as a function of in-plane and out-of-plane scattering vector components. The two principal mechanical parameters of the membranes, namely, bending rigidity and compression modulus, can be quantified by full calculation of scattering functions with the aid of an effective cut-off radius that takes the finite sample size into consideration. The bulkier \u201cbent\u201d Gb3 trisaccharide group makes the membrane mechanics distinctly different from cylindrical disaccharide (lactose) head groups and shorter \u201cbent\u201d disaccharide (gentiobiose) head groups. The mechanical characterization of membranes enriched with complex glycolipids has high importance in understanding the mechanisms of diseases such as sphingolipidoses caused by the accumulation of non-degenerated glycosphingolipids in lysosomes or inhibition of protein synthesis triggered by the specific binding of Shiga toxin to Gb3.<\/jats:p>","DOI":"10.1063\/1.4918585","type":"journal-article","created":{"date-parts":[[2015,4,21]],"date-time":"2015-04-21T17:00:52Z","timestamp":1429635652000},"update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":9,"title":["Influence of length and conformation of saccharide head groups on the mechanics of glycolipid membranes: Unraveled by off-specular neutron scattering"],"prefix":"10.1063","volume":"142","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3394-2147","authenticated-orcid":false,"given":"Akihisa","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Institute of Physical Chemistry, University of Heidelberg 1 Physical Chemistry of Biosystems, , 69120 Heidelberg, Germany"},{"name":"Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University 2 , Kyoto 606-8501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wasim","family":"Abuillan","sequence":"additional","affiliation":[{"name":"Institute of Physical Chemistry, University of Heidelberg 1 Physical Chemistry of Biosystems, , 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5597-1750","authenticated-orcid":false,"given":"Alexandra S.","family":"Burk","sequence":"additional","affiliation":[{"name":"Institute of Physical Chemistry, University of Heidelberg 1 Physical Chemistry of Biosystems, , 69120 Heidelberg, Germany"},{"name":"Institute of Toxicology and Genetics, Karlsruhe Institute of Technology 3 , 76021 Karlsruhe, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"K\u00f6rner","sequence":"additional","affiliation":[{"name":"Institute of Physical Chemistry, University of Heidelberg 1 Physical Chemistry of Biosystems, , 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Ries","sequence":"additional","affiliation":[{"name":"Institute of Organic and Biomolecular Chemistry, University of G\u00f6ttingen 4 , 37077 G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel B.","family":"Werz","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry, Technische Universit\u00e4t Braunschweig 5 , 38106 Braunschweig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Dem\u00e9","sequence":"additional","affiliation":[{"name":"Institut Laue-Langevin 6 , 38042 Grenoble Cedex 9, Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motomu","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Institute of Physical Chemistry, University of Heidelberg 1 Physical Chemistry of Biosystems, , 69120 Heidelberg, Germany"},{"name":"Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University 2 , Kyoto 606-8501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"317","published-online":{"date-parts":[[2015,4,21]]},"reference":[{"issue":"2","key":"2023062615042804500_c1","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1529\/biophysj.107.127845","volume":"95","year":"2008","journal-title":"Biophys. 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