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The changes in biomechanical properties of the lens and cornea are closely associated with common diseases, including presbyopia and cataract. Currently, most in vivo elasticity studies of the anterior eye focus on the measurement of the cornea, while lens measurement remains challenging. To better understand the anterior segment of the eye, we developed an optical coherence elastography system utilizing acoustic radiation force excitation to simultaneously assess the elasticities of the crystalline lens and the cornea in vivo. A swept light source was integrated into the system to provide an enhanced imaging range that covers both the lens and the cornea. Additionally, the oblique imaging approach combined with orthogonal excitation also improved the image quality. The system was tested through first ex vivo and then in vivo experiments using a rabbit model. The elasticities of corneal and lens tissue in an excised normal whole-globe and a cold cataract model were measured to reveal that cataractous lenses have a higher Young\u2019s modulus. Simultaneous in vivo elasticity measurements of the lens and cornea were performed in a rabbit model to demonstrate the correlations between elasticity and intraocular pressure and between elasticity and age. To the best of our knowledge, we demonstrated the first in vivo elasticity of imaging of both the lens and cornea using acoustic radiation force-optical coherence elastography, thereby providing a potential powerful clinical tool to advance ophthalmic research in disorders affecting the lens and the cornea.<\/jats:p>","DOI":"10.1063\/1.5118258","type":"journal-article","created":{"date-parts":[[2019,10,8]],"date-time":"2019-10-08T18:44:21Z","timestamp":1570560261000},"update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":77,"title":["Simultaneously imaging and quantifying <i>in vivo<\/i> mechanical properties of crystalline lens and cornea using optical coherence elastography with acoustic radiation force excitation"],"prefix":"10.1063","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3468-9235","authenticated-orcid":false,"given":"Yan","family":"Li","sequence":"first","affiliation":[{"name":"Beckman Laser Institute, University of California, Irvine 1 , Irvine, California 92612, USA"},{"name":"Department of Biomedical Engineering, University of California, Irvine 2 , Irvine, California 92617, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2601-4967","authenticated-orcid":false,"given":"Jiang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Beckman Laser Institute, University of California, Irvine 1 , Irvine, California 92612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason J.","family":"Chen","sequence":"additional","affiliation":[{"name":"Beckman Laser Institute, University of California, Irvine 1 , Irvine, California 92612, USA"},{"name":"Department of Biomedical Engineering, University of California, Irvine 2 , Irvine, California 92617, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junxiao","family":"Yu","sequence":"additional","affiliation":[{"name":"Beckman Laser Institute, University of California, Irvine 1 , Irvine, California 92612, USA"},{"name":"Department of Biomedical Engineering, University of California, Irvine 2 , Irvine, California 92617, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi","family":"Jin","sequence":"additional","affiliation":[{"name":"Beckman Laser Institute, University of California, Irvine 1 , Irvine, California 92612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusi","family":"Miao","sequence":"additional","affiliation":[{"name":"Beckman Laser Institute, University of California, Irvine 1 , Irvine, California 92612, USA"},{"name":"Department of Biomedical Engineering, University of California, Irvine 2 , Irvine, California 92617, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew W.","family":"Browne","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of California, Irvine 2 , Irvine, California 92617, USA"},{"name":"Department of Ophthalmology, School of Medicine, University of California, Irvine 3 , Irvine, California 92617, USA"},{"name":"Gavin Herbert Eye Institute, University of California, Irvine 4 , Irvine, California 92697, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qifa","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Biomedical Engineering, University of Southern California 5 , Los Angeles, California 90089, USA"},{"name":"Roski Eye Institute, University of Southern California 6 , Los Angeles, California 90007, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4584-4560","authenticated-orcid":false,"given":"Zhongping","family":"Chen","sequence":"additional","affiliation":[{"name":"Beckman Laser Institute, University of California, Irvine 1 , Irvine, California 92612, USA"},{"name":"Department of Biomedical Engineering, University of California, Irvine 2 , Irvine, California 92617, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"317","published-online":{"date-parts":[[2019,10,8]]},"reference":[{"issue":"5","key":"2023071522454296200_c1","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/0014-4835(82)90040-9","article-title":"Comparison of mechanical properties of keratoconus and normal corneas","volume":"35","year":"1982","journal-title":"Exp. 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