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In this report, we investigate the stability of rosette aggregates in malaria caused by Plasmodium falciparum in microflows. These flows are created in microfluidic channels with stenosis-like constrictions of different widths down to ones narrower as the rosette's diameter. High speed videos were recorded and analyzed by a MATLAB\u00a9 based tracking software (SURF: SUrvival of Rosettes in Flow). We find a correlation of rosette size, channel diameter, and blood group regarding the mobility of the rosettes. Following the concept of a thermodynamic model, we find a critical width of the stenosis for rosette rupture during their passage. Our data reveal that under physiologically relevant conditions, rosettes in blood group A have a higher rosette frequency and stability as compared to blood group O (BG O), which constitutes a crucial factor promoting the observed protection in BG O individuals against severe malaria in non-O individuals.<\/jats:p>","DOI":"10.1063\/1.5125038","type":"journal-article","created":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T10:45:02Z","timestamp":1584701102000},"update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":14,"title":["Blood group and size dependent stability of <i>P. falciparum<\/i> infected red blood cell aggregates in capillaries"],"prefix":"10.1063","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4815-0337","authenticated-orcid":false,"given":"Anna Martina","family":"J\u00f6tten","sequence":"first","affiliation":[{"name":"Institute of Physics, University of Augsburg 1 , 86159 Augsburg, Germany"},{"name":"Center for NanoScience (CeNS), Ludwig-Maximilians-Universit\u00e4t 2 , Munich 80799, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Moll","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet 3 , Box 280, 171 77 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mats","family":"Wahlgren","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet 3 , Box 280, 171 77 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9399-9946","authenticated-orcid":false,"given":"Achim","family":"Wixforth","sequence":"additional","affiliation":[{"name":"Institute of Physics, University of Augsburg 1 , 86159 Augsburg, Germany"},{"name":"Center for NanoScience (CeNS), Ludwig-Maximilians-Universit\u00e4t 2 , Munich 80799, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7103-7060","authenticated-orcid":false,"given":"Christoph","family":"Westerhausen","sequence":"additional","affiliation":[{"name":"Institute of Physics, University of Augsburg 1 , 86159 Augsburg, Germany"},{"name":"Center for NanoScience (CeNS), Ludwig-Maximilians-Universit\u00e4t 2 , Munich 80799, Germany"},{"name":"Institute of Theoretical Medicine, University of Augsburg 4 , 86159 Augsburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"317","published-online":{"date-parts":[[2020,3,20]]},"reference":[{"key":"2023062410351437300_c1","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1093\/oxfordjournals.aje.a120739","article-title":"Relation of blood groups to infection. 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