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Here, we assimilated a model of intermittent delay feedback control during quiet standing into postural sway data from healthy young and elderly individuals as well as patients with Parkinson\u2019s disease to elucidate the possible mechanisms of instability. Specifically, we estimated the joint probability distribution of a set of parameters in the model using the Bayesian parameter inference such that the model with the inferred parameters can best-fit sway data for each individual. It was expected that the parameter values for three populations would distribute differently in the parameter space depending on their balance capability. Because the intermittent control model is parameterized by a parameter associated with the degree of intermittency in the control, it can represent not only the intermittent model but also the traditional continuous control model with no intermittency. We showed that the inferred parameter values for the three groups of individuals are classified into two major groups in the parameter space: one represents the intermittent control mostly for healthy people and patients with mild postural symptoms and the other the continuous control mostly for some elderly and patients with severe postural symptoms. The results of this study may be interpreted by postulating that increased postural instability in most Parkinson\u2019s patients and some elderly persons might be characterized as a dynamical disease.<\/jats:p>","DOI":"10.1063\/5.0022319","type":"journal-article","created":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T16:04:27Z","timestamp":1606233867000},"update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":56,"title":["Postural instability via a loss of intermittent control in elderly and patients with Parkinson\u2019s disease: A model-based and data-driven approach"],"prefix":"10.1063","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9681-7856","authenticated-orcid":false,"given":"Yasuyuki","family":"Suzuki","sequence":"first","affiliation":[{"name":"Graduate School of Engineering Science, Osaka University 1 , Osaka 5608531, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9571-0392","authenticated-orcid":false,"given":"Akihiro","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Graduate School of Engineering Science, Osaka University 1 , Osaka 5608531, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7629-1850","authenticated-orcid":false,"given":"Matija","family":"Milosevic","sequence":"additional","affiliation":[{"name":"Graduate School of Engineering Science, Osaka University 1 , Osaka 5608531, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6659-3297","authenticated-orcid":false,"given":"Kunihiko","family":"Nomura","sequence":"additional","affiliation":[{"name":"Department of Information Technology and Social Sciences, Osaka University of Economics 2 , Osaka 5338533, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Tanahashi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Osaka Rosai Hospital 3 , Osaka 5918025, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuyuki","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Osaka Toneyama Medical Center 4 , Osaka 5608552, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saburo","family":"Sakoda","sequence":"additional","affiliation":[{"name":"Department of Neurology, Osaka Toneyama Medical Center 4 , Osaka 5608552, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3837-8004","authenticated-orcid":false,"given":"Pietro","family":"Morasso","sequence":"additional","affiliation":[{"name":"Center for Human Technologies, Istituto Italiano di Tecnologia 5 , Genoa 16163, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6545-2097","authenticated-orcid":false,"given":"Taishin","family":"Nomura","sequence":"additional","affiliation":[{"name":"Graduate School of Engineering Science, Osaka University 1 , Osaka 5608531, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"317","published-online":{"date-parts":[[2020,11,24]]},"reference":[{"key":"2024031518054717600_c1","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/S0140-6736(12)61263-X","article-title":"Video capture of the circumstances of falls in elderly people residing in long-term care: An observational study","volume":"381","year":"2013","journal-title":"Lancet"},{"key":"2024031518054717600_c2","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1097\/00005373-200101000-00021","article-title":"Geriatric falls: Injury severity is high and disproportionate to mechanism","volume":"50","year":"2001","journal-title":"J. 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