{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:32:40Z","timestamp":1790757160212,"version":"4.1.0"},"reference-count":60,"publisher":"AIP Publishing","issue":"12","content-domain":{"domain":["pubs.aip.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:p>Even though face masks are well accepted as tools useful in reducing COVID-19 transmissions, their effectiveness in reducing viral loads in the respiratory tract is unclear. Wearing a mask will significantly alter the airflow and particle dynamics near the face, which can change the inhalability of ambient particles. The objective of this study is to investigate the effects of wearing a surgical mask on inspiratory airflow and dosimetry of airborne, virus-laden aerosols on the face and in the respiratory tract. A computational model was developed that comprised a pleated surgical mask, a face model, and an image-based upper airway geometry. The viral load in the nose was particularly examined with and without a mask. Results show that when breathing without a mask, air enters the mouth and nose through specific paths. When wearing a mask, however, air enters the mouth and nose through the entire surface of the mask at lower speeds, which favors the inhalation of ambient aerosols into the nose. With a 65% filtration efficiency (FE) typical for a three-layer surgical mask, wearing a mask reduces dosimetry for all micrometer particles except those of size 1 \u00b5m\u20133 \u00b5m, for which equivalent dosimetry with and without a mask in the upper airway was predicted. Wearing a mask reduces particle penetration into the lungs, regardless of the FE of the mask. The results also show that mask-wearing protects the upper airway (particularly the nose and larynx) best from particles larger than 10 \u00b5m while protecting the lungs best from particles smaller than 10 \u00b5m.<\/jats:p>","DOI":"10.1063\/5.0034580","type":"journal-article","created":{"date-parts":[[2020,12,15]],"date-time":"2020-12-15T15:46:36Z","timestamp":1608047196000},"update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":60,"title":["Effects of mask-wearing on the inhalability and deposition of airborne\n          SARS-CoV-2 aerosols in human upper airway"],"prefix":"10.1063","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6423-0759","authenticated-orcid":false,"given":"Jinxiang","family":"Xi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0275-5119","authenticated-orcid":false,"given":"Xiuhua April","family":"Si","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramaswamy","family":"Nagarajan","sequence":"additional","affiliation":[{"name":"Department of Plastics Engineering, University of Massachusetts at Lowell 3 , 1 University Ave., Lowell, Massachusetts 01854,","place":["USA"]},{"name":"Fabric Discovery Center, University of Massachusetts at Lowell 4 , 110 Canal St., Lowell, Massachusetts 01852,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"317","published-online":{"date-parts":[[2020,12,15]]},"reference":[{"key":"2025052317362105000_c1","doi-asserted-by":"publisher","first-page":"101704","DOI":"10.1063\/5.0029186","article-title":"Reducing chances of COVID-19\n            infection by a cough cloud in a closed space","volume":"32","year":"2020","journal-title":"Phys.\n            Fluids"},{"key":"2025052317362105000_c2","doi-asserted-by":"publisher","first-page":"097102","DOI":"10.1063\/5.0022859","article-title":"Transmission of airborne virus\n            through sneezed and coughed droplets","volume":"32","year":"2020","journal-title":"Phys. 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