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The deadly corona virus-containing aerosol enters the atmospheric air through sneezing, exhalation, or talking, assembling with the particulate matter, and subsequently transferring to the respiratory system. This recent outbreak illustrates that the severe acute respiratory syndrome (SARS) coronavirus-2 is deadlier for aged people than for other age groups. It is evident that the airway diameter reduces with age, and an accurate understanding of SARS aerosol transport through different elderly people's airways could potentially help the overall respiratory health assessment, which is currently lacking in the literature. This first-ever study investigates SARS COVID-2 aerosol transport in age-specific airway systems. A highly asymmetric age-specific airway model and fluent solver (ANSYS 19.2) are used for the investigation. The computational fluid dynamics measurement predicts higher SARS COVID-2 aerosol concentration in the airway wall for older adults than for younger people. The numerical study reports that the smaller SARS coronavirus-2 aerosol deposition rate in the right lung is higher than that in the left lung, and the opposite scenario occurs for the larger SARS coronavirus-2 aerosol rate. The numerical results show a fluctuating trend of pressure at different generations of the age-specific model. The findings of this study would improve the knowledge of SARS coronavirus-2 aerosol transportation to the upper airways which would thus ameliorate the targeted aerosol drug delivery system.<\/jats:p>","DOI":"10.1063\/5.0061627","type":"journal-article","created":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T10:53:42Z","timestamp":1629370422000},"update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":37,"title":["How severe acute respiratory syndrome coronavirus-2 aerosol propagates through the age-specific upper airways"],"prefix":"10.1063","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6264-3886","authenticated-orcid":false,"given":"Mohammad S.","family":"Islam","sequence":"first","affiliation":[{"name":"School of Mechanical and Mechatronic Engineering, University of Technology Sydney (UTS) 1 , 15 Broadway, Ultimo, New South Wales 2007,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3413-3667","authenticated-orcid":false,"given":"Puchanee","family":"Larpruenrudee","sequence":"additional","affiliation":[{"name":"School of Mechanical and Mechatronic Engineering, University of Technology Sydney (UTS) 1 , 15 Broadway, Ultimo, New South Wales 2007,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9962-8919","authenticated-orcid":false,"given":"Suvash C.","family":"Saha","sequence":"additional","affiliation":[{"name":"School of Mechanical and Mechatronic Engineering, University of Technology Sydney (UTS) 1 , 15 Broadway, Ultimo, New South Wales 2007,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oveis","family":"Pourmehran","sequence":"additional","affiliation":[{"name":"School of Mechanical Engineering, The University of Adelaide 2 , Adelaide, South Australia 5005, and Department of Surgery\u2014Otolaryngology Head and Neck Surgery, The University of Adelaide, Adelaide, South Australia 5005,","place":["Australia Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8772-0988","authenticated-orcid":false,"given":"Akshoy Ranjan","family":"Paul","sequence":"additional","affiliation":[{"name":"Department of Applied Mechanics, Motilal Nehru National Institute of Technology Allahabad 3 , Prayagraj 211004, Uttar Pradesh,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6424-2442","authenticated-orcid":false,"given":"Tevfik","family":"Gemci","sequence":"additional","affiliation":[{"name":"Braun Medical 4 , Irvine, California 92614,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Collins","sequence":"additional","affiliation":[{"name":"Biomechanics International, Cranberry Township 5 , Pennsylvania 16066,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1880-9161","authenticated-orcid":false,"given":"Gunther","family":"Paul","sequence":"additional","affiliation":[{"name":"James Cook University, Australian Institute of Tropical Health and Medicine, Townsville, Queensland 6 4810,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuantong","family":"Gu","sequence":"additional","affiliation":[{"name":"School of Mechanical, Medical and Process Engineering, Faculty of Engineering, Queensland University of Technology 7 , Brisbane 4000,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"317","published-online":{"date-parts":[[2021,8,19]]},"reference":[{"issue":"1","key":"2025052815220227600_c1","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1016\/j.sjbs.2020.11.001","article-title":"SARS-CoV-2 associated COVID-19 in geriatric population: A brief narrative review","volume":"28","year":"2021","journal-title":"Saudi J. 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