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Lamins interact with a wide range of nuclear proteins and are involved in numerous nuclear and cellular functions. Within the nucleus, they play roles in chromatin organization and gene regulation, nuclear shape, size, and mechanics, and the organization and anchorage of nuclear pore complexes. At the whole cell level, they are involved in the organization of the cytoskeleton, cell motility, and mechanotransduction. The expression of different lamin isoforms has been associated with developmental progression, differentiation, and tissue-specific functions. Mutations in lamins and their binding proteins result in over 15 distinct human diseases, referred to as laminopathies. The laminopathies include muscular (e.g., Emery\u2013Dreifuss muscular dystrophy and dilated cardiomyopathy), neurological (e.g., microcephaly), and metabolic (e.g., familial partial lipodystrophy) disorders as well as premature aging diseases (e.g., Hutchinson\u2013Gilford Progeria and Werner syndromes). How lamins contribute to the etiology of laminopathies is still unknown. In this review article, we summarize major recent findings on the structure, organization, and multiple functions of lamins in nuclear and more global cellular processes.<\/jats:p>","DOI":"10.1063\/5.0082656","type":"journal-article","created":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T10:37:36Z","timestamp":1643711856000},"update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":97,"title":["Nuclear lamins: Structure and function in mechanobiology"],"prefix":"10.1063","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5713-0231","authenticated-orcid":false,"given":"Amir","family":"Vahabikashi","sequence":"first","affiliation":[{"name":"Department of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University 1 , Chicago, Illinois 60611, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen A.","family":"Adam","sequence":"additional","affiliation":[{"name":"Department of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University 1 , Chicago, Illinois 60611, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ohad","family":"Medalia","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Zurich 2 , Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Goldman","sequence":"additional","affiliation":[{"name":"Department of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University 1 , Chicago, Illinois 60611, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"317","published-online":{"date-parts":[[2022,2,1]]},"reference":[{"key":"2023080908404022400_c1","doi-asserted-by":"publisher","first-page":"a023556","DOI":"10.1101\/cshperspect.a023556","article-title":"The nucleoskeleton","volume":"9","year":"2017","journal-title":"Cold Spring Harbor Perspect. 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