{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T04:10:56Z","timestamp":1782274256353,"version":"3.54.5"},"reference-count":27,"publisher":"AIP Publishing","issue":"4","funder":[{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"crossref","award":["PID2020-113582GB-I00"],"award-info":[{"award-number":["PID2020-113582GB-I00"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007329","name":"Universidad del Valle","doi-asserted-by":"crossref","award":["CI-165"],"award-info":[{"award-number":["CI-165"]}],"id":[{"id":"10.13039\/501100007329","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100010067","name":"Gobierno de Arag\u00f3n FENOL group","doi-asserted-by":"publisher","award":["E36-17R"],"award-info":[{"award-number":["E36-17R"]}],"id":[{"id":"10.13039\/501100010067","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["709978"],"award-info":[{"award-number":["709978"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pubs.aip.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,4,1]]},"abstract":"<jats:p>Over the last decade, the release of Wolbachia-infected Aedes aegypti into the natural habitat of this mosquito species has become the most sustainable and long-lasting technique to prevent and control vector-borne diseases, such as dengue, zika, or chikungunya. However, the limited resources to generate such mosquitoes and their effective distribution in large areas dominated by the Aedes aegypti vector represent a challenge for policymakers. Here, we introduce a mathematical framework for the spread of dengue in which competition between wild and Wolbachia-infected mosquitoes, the cross-contagion patterns between humans and vectors, the heterogeneous distribution of the human population in different areas, and the mobility flows between them are combined. Our framework allows us to identify the most effective areas for the release of Wolbachia-infected mosquitoes to achieve a large decrease in the global dengue prevalence.<\/jats:p>","DOI":"10.1063\/5.0087435","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T16:46:11Z","timestamp":1650386771000},"update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":6,"title":["A metapopulation approach to identify targets for <i>Wolbachia<\/i>-based dengue control"],"prefix":"10.1063","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3885-607X","authenticated-orcid":false,"given":"A.","family":"Reyna-Lara","sequence":"first","affiliation":[{"name":"GOTHAM Lab, Institute for Biocomputation and Physics of Complex Systems (BIFI) and Departamento de F\u00edsica de la Materia Condensada, University of Zaragoza 1 , 50018 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6388-4056","authenticated-orcid":false,"given":"D.","family":"Soriano-Pa\u00f1os","sequence":"additional","affiliation":[{"name":"GOTHAM Lab, Institute for Biocomputation and Physics of Complex Systems (BIFI) and Departamento de F\u00edsica de la Materia Condensada, University of Zaragoza 1 , 50018 Zaragoza, Spain"},{"name":"Instituto Gulbenkian de Ci\u00eancia (IGC) 2 , 2780-156 Oeiras, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0647-500X","authenticated-orcid":false,"given":"J. H.","family":"Arias-Castro","sequence":"additional","affiliation":[{"name":"Department of Mathematics, Universidad del Valle 3 , 760032 Santiago de Cali, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9747-0671","authenticated-orcid":false,"given":"H. J.","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Mathematics, Universidad del Valle 3 , 760032 Santiago de Cali, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5204-1937","authenticated-orcid":false,"given":"J.","family":"G\u00f3mez-Garde\u00f1es","sequence":"additional","affiliation":[{"name":"GOTHAM Lab, Institute for Biocomputation and Physics of Complex Systems (BIFI) and Departamento de F\u00edsica de la Materia Condensada, University of Zaragoza 1 , 50018 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"317","published-online":{"date-parts":[[2022,4,18]]},"reference":[{"key":"2024031600280506600_c1"},{"key":"2024031600280506600_c2","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1016\/S1473-3099(16)00026-8","article-title":"The global burden of dengue: An analysis from the global burden of disease study 2013","volume":"16","year":"2016","journal-title":"Lancet Infect. Dis."},{"key":"2024031600280506600_c3","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1038\/nature12060","article-title":"The global distribution and burden of dengue","volume":"496","year":"2013","journal-title":"Nature"},{"key":"2024031600280506600_c4","doi-asserted-by":"publisher","first-page":"S80","DOI":"10.1016\/j.ijid.2019.01.029","article-title":"Dengue vaccine development: Global and Indian scenarios","volume":"84","year":"2019","journal-title":"Int. J. Infect. Dis."},{"key":"2024031600280506600_c5","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1111\/nyas.13950","article-title":"Impact of recent and future climate change on vector-borne diseases","volume":"1436","year":"2019","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"2024031600280506600_c6","doi-asserted-by":"publisher","first-page":"467","DOI":"10.4269\/ajtmh.2007.77.467","article-title":"Insecticide resistance mechanisms of Brazilian Aedes aegypti populations from 2001 to 2004","volume":"77","year":"2007","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"2024031600280506600_c7","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1016\/j.cell.2009.11.042","article-title":"A Wolbachia symbiont in Aedes aegypti limits infection with dengue, chikungunya, and plasmodium","volume":"139","year":"2009","journal-title":"Cell"},{"key":"2024031600280506600_c8","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1038\/nature10355","article-title":"The wMel Wolbachia strain blocks dengue and invades caged Aedes aegypti populations","volume":"476","year":"2011","journal-title":"Nature"},{"key":"2024031600280506600_c9","volume-title":"Influential Passengers: Inherited Microorganisms and Arthropod Reproduction","year":"1997"},{"key":"2024031600280506600_c10","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1038\/353440a0","article-title":"Rapid spread of an inherited incompatibility factor in California Drosophila","volume":"353","year":"1991","journal-title":"Nature"},{"key":"2024031600280506600_c11","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1038\/s41567-017-0022-7","article-title":"Critical regimes driven by recurrent mobility patterns of reaction\u2013diffusion processes in networks","volume":"14","year":"2018","journal-title":"Nat. Phys."},{"key":"2024031600280506600_c12","doi-asserted-by":"publisher","first-page":"031039","DOI":"10.1103\/PhysRevX.8.031039","article-title":"Spreading processes in multiplex metapopulations containing different mobility networks","volume":"8","year":"2018","journal-title":"Phys. Rev. X"},{"key":"2024031600280506600_c13","doi-asserted-by":"publisher","first-page":"013312","DOI":"10.1103\/PhysRevResearch.2.013312","article-title":"Vector-borne epidemics driven by human mobility","volume":"2","year":"2020","journal-title":"Phys. Rev. Res."},{"key":"2024031600280506600_c14","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1603\/0022-2585-38.4.548","article-title":"Temperature effects on the dynamics of Aedes albopictus (Diptera: Culicidae) populations in the laboratory","volume":"38","year":"2001","journal-title":"J. Med. Entomol."},{"key":"2024031600280506600_c15","first-page":"301","article-title":"Life table characteristics of Aedes aegypti (Diptera: Culicidae) from Saudi Arabia","volume":"30","year":"2013","journal-title":"Trop. Biomed."},{"key":"2024031600280506600_c16","doi-asserted-by":"publisher","first-page":"12534","DOI":"10.1073\/pnas.0508879103","article-title":"Wolbachia transinfection in Aedes aegypti: A potential gene driver of dengue vectors","volume":"103","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2024031600280506600_c17","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1073\/pnas.1112021108","article-title":"Wolbachia strain wMel induces cytoplasmic incompatibility and blocks dengue transmission in Aedes albopictus","volume":"109","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2024031600280506600_c18","unstructured":"D.\u2008Vicencio, O.\u2008Vasilieva, and P.\u2008Gajardo, \u201cMonotonicity properties arising in a simple model of Wolbachia invasion for wild mosquito populations,\u201d arXiv:2011.10501 (2020)."},{"key":"2024031600280506600_c19","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.micinf.2009.12.011","article-title":"The dengue vector Aedes aegypti: What comes next","volume":"12","year":"2010","journal-title":"Microbes Infect."},{"key":"2024031600280506600_c20","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1093\/jmedent\/42.1.57","article-title":"An update on the potential of North American mosquitoes (Diptera: Culicidae) to transmit West Nile virus","volume":"42","year":"2005","journal-title":"J. Med. Entomol."},{"key":"2024031600280506600_c21","volume-title":"Cali En Cifras 2013","year":"2013"},{"key":"2024031600280506600_c22","doi-asserted-by":"publisher","first-page":"70","DOI":"10.3389\/fphys.2012.00070","article-title":"Eventual role of asymptomatic cases of dengue for the introduction and spread of dengue viruses in non-endemic regions","volume":"3","year":"2012","journal-title":"Front. Physiol."},{"key":"2024031600280506600_c23","doi-asserted-by":"publisher","first-page":"e1244","DOI":"10.1371\/journal.pntd.0001244","article-title":"Clinical and virological factors influencing the performance of a NS1 antigen-capture assay and potential use as a marker of dengue disease severity","volume":"5","year":"2011","journal-title":"PLoS Neglected Trop. Dis."},{"key":"2024031600280506600_c24","volume-title":"An\u00e1lisis de Situaci\u00f3n Integrada de Salud","year":"2016"},{"key":"2024031600280506600_c25"},{"key":"2024031600280506600_c26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13071-018-2643-9","article-title":"Natural vertical transmission of dengue virus in Aedes aegypti and Aedes albopictus: A systematic review","volume":"11","year":"2018","journal-title":"Parasites Vectors"},{"key":"2024031600280506600_c27","doi-asserted-by":"publisher","first-page":"2177","DOI":"10.1056\/NEJMoa2030243","article-title":"Efficacy of Wolbachia-infected mosquito deployments for the control of dengue","volume":"384","year":"2021","journal-title":"N. Engl. J. Med."}],"container-title":["Chaos: An Interdisciplinary Journal of Nonlinear Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.aip.org\/aip\/cha\/article-pdf\/doi\/10.1063\/5.0087435\/19805336\/041105_1_online.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.aip.org\/aip\/cha\/article-pdf\/doi\/10.1063\/5.0087435\/19805336\/041105_1_online.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T00:28:19Z","timestamp":1710548899000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.aip.org\/cha\/article\/32\/4\/041105\/2835607\/A-metapopulation-approach-to-identify-targets-for"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,1]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4,1]]}},"URL":"https:\/\/doi.org\/10.1063\/5.0087435","relation":{},"ISSN":["1054-1500","1089-7682"],"issn-type":[{"value":"1054-1500","type":"print"},{"value":"1089-7682","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,4]]},"published":{"date-parts":[[2022,4,1]]},"article-number":"041105"}}