{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:21:10Z","timestamp":1791048070382,"version":"4.1.0"},"reference-count":303,"publisher":"AIP Publishing","issue":"3","license":[{"start":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T00:00:00Z","timestamp":1663632000000},"content-version":"vor","delay-in-days":19,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T00:00:00Z","timestamp":1663632000000},"content-version":"tdm","delay-in-days":19,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2015-05512"],"award-info":[{"award-number":["RGPIN-2015-05512"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"publisher","award":["Advanced Cellular Microenvironments"],"award-info":[{"award-number":["Advanced Cellular Microenvironments"]}],"id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]},{"name":"McGill MI4 Research Startup Grant"}],"content-domain":{"domain":["pubs.aip.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,9,1]]},"abstract":"<jats:p>Innate immunity forms the core of the human body's defense system against infection, injury, and foreign objects. It aims to maintain homeostasis by promoting inflammation and then initiating tissue repair, but it can also lead to disease when dysregulated. Although innate immune cells respond to their physical microenvironment and carry out intrinsically mechanical actions such as migration and phagocytosis, we still do not have a complete biophysical description of innate immunity. Here, we review how engineering tools can be used to study innate immune cell biophysics. We first provide an overview of innate immunity from a biophysical perspective, review the biophysical factors that affect the innate immune system, and then explore innate immune cell biophysics in the context of migration, phagocytosis, and phenotype polarization. Throughout the review, we highlight how physical microenvironments can be designed to probe the innate immune system, discuss how biophysical insight gained from these studies can be used to generate a more comprehensive description of innate immunity, and briefly comment on how this insight could be used to develop mechanical immune biomarkers and immunomodulatory therapies.<\/jats:p>","DOI":"10.1063\/5.0098578","type":"journal-article","created":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T09:35:54Z","timestamp":1663666554000},"update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":7,"title":["Engineering physical microenvironments to study innate immune cell biophysics"],"prefix":"10.1063","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9944-9542","authenticated-orcid":false,"given":"Nikita","family":"Kalashnikov","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering, McGill University 1 , Montreal, Quebec H3A 0G4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8950-2212","authenticated-orcid":false,"given":"Christopher","family":"Moraes","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, McGill University 1 , Montreal, Quebec H3A 0G4, Canada"},{"name":"Department of Biological and Biomedical Engineering, McGill University 2 , Montreal, Quebec H3A 0G4, Canada"},{"name":"Goodman Cancer Research Center, McGill University 3 , Montreal, Quebec H3A 0G4, Canada"},{"name":"Division of Experimental Medicine, McGill University 4 , Montreal, Quebec H3A 0G4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"317","published-online":{"date-parts":[[2022,9,20]]},"reference":[{"key":"2023080908424339600_c1","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.jaci.2005.05.036","article-title":"Innate immune responses to infection","volume":"116","year":"2005","journal-title":"J. Allergy Clin. Immunol."},{"key":"2023080908424339600_c2","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1038\/s41590-018-0064-8","article-title":"Innate immune responses to trauma","volume":"19","year":"2018","journal-title":"Nat. Immunol."},{"key":"2023080908424339600_c3","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.smim.2007.11.004","article-title":"Foreign body reaction to biomaterials","volume":"20","year":"2008","journal-title":"Semin. Immunol."},{"key":"2023080908424339600_c4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41551-016-0007","article-title":"Examination of the foreign body response to biomaterials by nonlinear intravital microscopy","volume":"1","year":"2017","journal-title":"Nat. Biomed. Eng."},{"key":"2023080908424339600_c5","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1038\/nri3070","article-title":"Monocyte recruitment during infection and inflammation","volume":"11","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"2023080908424339600_c6","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1038\/nri1785","article-title":"Neutrophils and immunity: Challenges and opportunities","volume":"6","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"2023080908424339600_c7","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1038\/nature07201","article-title":"Origin and physiological roles of inflammation","volume":"454","year":"2008","journal-title":"Nature"},{"key":"2023080908424339600_c8","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1056\/NEJMra1300575","article-title":"Fibrosis\u2014A common pathway to organ injury and failure","volume":"372","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"2023080908424339600_c9","doi-asserted-by":"publisher","first-page":"1901682","DOI":"10.1002\/adhm.201901682","article-title":"Engineered biomaterial platforms to study fibrosis","volume":"9","year":"2020","journal-title":"Adv. Healthcare Mater."},{"key":"2023080908424339600_c10","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1038\/nri.2017.10","article-title":"Neutrophils as protagonists and targets in chronic inflammation","volume":"17","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"2023080908424339600_c11","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1038\/s41569-018-0064-2","article-title":"Inflammageing: Chronic inflammation in ageing, cardiovascular disease, and frailty","volume":"15","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"2023080908424339600_c12","doi-asserted-by":"publisher","first-page":"1822","DOI":"10.1038\/s41591-019-0675-0","article-title":"Chronic inflammation in the etiology of disease across the life span","volume":"25","year":"2019","journal-title":"Nat. Med."},{"key":"2023080908424339600_c13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/17460441.2020.1822815","article-title":"Disentangling the fibrous microenvironment: Designer culture models for improved drug discovery","volume":"16","year":"2020","journal-title":"Expert Opin. Drug Discovery"},{"key":"2023080908424339600_c14","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1038\/nmat4290","article-title":"Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates","volume":"14","year":"2015","journal-title":"Nat. Mater."},{"key":"2023080908424339600_c15","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1039\/C6BM00224B","article-title":"Topographical modulation of macrophage phenotype by shrink-film multi-scale wrinkles","volume":"4","year":"2016","journal-title":"Biomater. Sci."},{"key":"2023080908424339600_c16","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/j.biomaterials.2018.11.002","article-title":"Divergent immune responses to synthetic and biological scaffolds","volume":"192","year":"2019","journal-title":"Biomaterials"},{"key":"2023080908424339600_c17","doi-asserted-by":"publisher","first-page":"234ra58","DOI":"10.1126\/scitranslmed.3008085","article-title":"An acellular biologic scaffold promotes skeletal muscle formation in mice and humans with volumetric muscle loss","volume":"6","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"2023080908424339600_c18","doi-asserted-by":"publisher","first-page":"16040","DOI":"10.1038\/natrevmats.2016.40","article-title":"Design, clinical translation and immunological response of biomaterials in regenerative medicine","volume":"1","year":"2016","journal-title":"Nat. Rev. Mater."},{"key":"2023080908424339600_c19","doi-asserted-by":"publisher","first-page":"2575","DOI":"10.1002\/adhm.201600532","article-title":"Methods for implant acceptance and wound healing: Material selection and implant location modulate macrophage and fibroblast phenotypes","volume":"5","year":"2016","journal-title":"Adv. Healthcare Mater."},{"key":"2023080908424339600_c20","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1126\/science.aar2955","article-title":"Biomaterials for tissue repair","volume":"363","year":"2019","journal-title":"Science"},{"key":"2023080908424339600_c21","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1038\/s41578-020-0209-x","article-title":"Engineered biomaterials for in situ tissue regeneration","volume":"5","year":"2020","journal-title":"Nat. Rev. Mater."},{"key":"2023080908424339600_c22","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1038\/ni.f.212","article-title":"Interstitial leukocyte migration and immune function","volume":"9","year":"2008","journal-title":"Nat. Immunol."},{"key":"2023080908424339600_c23","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1038\/nri3641","article-title":"Leukocyte migration in the interstitial space of non-lymphoid organs","volume":"14","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"2023080908424339600_c24","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1038\/s41556-017-0012-0","article-title":"Mechanoreciprocity in cell migration","volume":"20","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"2023080908424339600_c25","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.devcel.2016.06.023","article-title":"Diffusion barriers, mechanical forces, and the biophysics of phagocytosis","volume":"38","year":"2016","journal-title":"Dev. Cell"},{"key":"2023080908424339600_c26","doi-asserted-by":"publisher","first-page":"R24","DOI":"10.1016\/j.cub.2019.11.047","article-title":"Phagocytosis: Mechanosensing, traction forces, and a molecular clutch","volume":"30","year":"2020","journal-title":"Curr. Biol."},{"key":"2023080908424339600_c27","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.devcel.2005.12.006","article-title":"Mechanisms of mechanotransduction","volume":"10","year":"2006","journal-title":"Dev. Cell"},{"key":"2023080908424339600_c28","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1038\/nrm2597","article-title":"Mechanotransduction gone awry","volume":"10","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2023080908424339600_c29","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1038\/nrm3112","article-title":"Balancing forces: Architectural control of mechanotransduction","volume":"12","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2023080908424339600_c30","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1038\/nrm3896","article-title":"Mechanotransduction and extracellular matrix homeostasis","volume":"15","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2023080908424339600_c31","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1146\/annurev-bioeng-061008-124915","article-title":"Microengineered platforms for cell mechanobiology","volume":"11","year":"2009","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"2023080908424339600_c32","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1039\/c1ib00056j","article-title":"(Micro)managing the mechanical microenvironment","volume":"3","year":"2011","journal-title":"Integr. Biol."},{"key":"2023080908424339600_c33","doi-asserted-by":"publisher","first-page":"1494","DOI":"10.1002\/adma.201304431","article-title":"Integrated micro\/nanoengineered functional biomaterials for cell mechanics and mechanobiology: A materials perspective","volume":"26","year":"2014","journal-title":"Adv. Mater."},{"key":"2023080908424339600_c34","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1038\/ncb3564","article-title":"Quantifying forces in cell biology","volume":"19","year":"2017","journal-title":"Nat. Cell Biol."},{"key":"2023080908424339600_c35","doi-asserted-by":"publisher","first-page":"R745","DOI":"10.1016\/j.cub.2009.06.034","article-title":"The mechanical cell","volume":"19","year":"2009","journal-title":"Curr. Biol."},{"key":"2023080908424339600_c36","doi-asserted-by":"publisher","first-page":"041501","DOI":"10.1063\/5.0046093","article-title":"Revisiting tissue tensegrity: Biomaterial-based approaches to measure forces across length scales","volume":"5","year":"2021","journal-title":"APL Bioeng."},{"key":"2023080908424339600_c37","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.devcel.2011.06.015","article-title":"A Hitchhiker's guide to mechanobiology","volume":"21","year":"2011","journal-title":"Dev. Cell"},{"key":"2023080908424339600_c38","doi-asserted-by":"publisher","first-page":"583970","DOI":"10.3389\/fbioe.2020.583970","article-title":"Developmentally-inspired biomimetic culture models to produce functional islet-like cells from pluripotent precursors","volume":"8","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"2023080908424339600_c39","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1007\/s00018-014-1796-8","article-title":"Physical and mechanical regulation of macrophage phenotype and function","volume":"72","year":"2015","journal-title":"Cell. Mol. Life Sci."},{"key":"2023080908424339600_c40","doi-asserted-by":"publisher","first-page":"3105","DOI":"10.1016\/j.bbamcr.2015.07.015","article-title":"Mechanotransduction in neutrophil activation and deactivation","volume":"1853","year":"2015","journal-title":"Biochim. Biophys. Acta BBA"},{"key":"2023080908424339600_c41","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1038\/nri.2017.74","article-title":"Mechanical forces in the immune system","volume":"17","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"2023080908424339600_c42","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1146\/annurev-bioeng-062117-121224","article-title":"Mechanobiology of macrophages: How physical factors coregulate macrophage plasticity and phagocytosis","volume":"21","year":"2019","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"2023080908424339600_c43","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1038\/s41590-019-0491-1","article-title":"Mechanosensing through immunoreceptors","volume":"20","year":"2019","journal-title":"Nat. Immunol."},{"key":"2023080908424339600_c44","doi-asserted-by":"publisher","first-page":"e00057","DOI":"10.1128\/MMBR.00057-17","article-title":"The ontogeny of a neutrophil: Mechanisms of granulopoiesis and homeostasis","volume":"82","year":"2018","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"2023080908424339600_c45","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1038\/nri1733","article-title":"Monocyte and macrophage heterogeneity","volume":"5","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"2023080908424339600_c46","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.immuni.2016.02.024","article-title":"Tissue-resident macrophage ontogeny and homeostasis","volume":"44","year":"2016","journal-title":"Immunity"},{"key":"2023080908424339600_c47","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1038\/ni.2705","article-title":"Tissue-resident macrophages","volume":"14","year":"2013","journal-title":"Nat. Immunol."},{"key":"2023080908424339600_c48","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1038\/nri2156","article-title":"Getting to the site of inflammation: The leukocyte adhesion cascade updated","volume":"7","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"2023080908424339600_c49","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1038\/nrm2889","article-title":"Breaching multiple barriers: Leukocyte motility through venular walls and the interstitium","volume":"11","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2023080908424339600_c50","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/nri3399","article-title":"Neutrophil recruitment and function in health and inflammation","volume":"13","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"2023080908424339600_c51","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1016\/j.immuni.2014.10.008","article-title":"Leukocyte migration into inflamed tissues","volume":"41","year":"2014","journal-title":"Immunity"},{"key":"2023080908424339600_c52","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1038\/nri2852","article-title":"The impact of the extracellular matrix on inflammation","volume":"10","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"2023080908424339600_c53","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1146\/annurev-pathmechdis-012419-032847","article-title":"DAMPs, PAMPs, and LAMPs in immunity and sterile inflammation","volume":"15","year":"2020","journal-title":"Annu. Rev. Pathol. Mech. Dis."},{"key":"2023080908424339600_c54","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1038\/nrmicro1710","article-title":"Beneficial suicide: Why neutrophils die to make NETs","volume":"5","year":"2007","journal-title":"Nat. Rev. Microbiol."},{"key":"2023080908424339600_c55","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1038\/nm.4294","article-title":"An emerging role for neutrophil extracellular traps in noninfectious disease","volume":"23","year":"2017","journal-title":"Nat. Med."},{"key":"2023080908424339600_c56","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1038\/nri2779","article-title":"Phagocyte partnership during the onset and resolution of inflammation","volume":"10","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"2023080908424339600_c57","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1038\/ni.1937","article-title":"Macrophage plasticity and interaction with lymphocyte subsets: Cancer as a paradigm","volume":"11","year":"2010","journal-title":"Nat. Immunol."},{"key":"2023080908424339600_c58","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1038\/nri3024","article-title":"Neutrophils in the activation and regulation of innate and adaptive immunity","volume":"11","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"2023080908424339600_c59","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.immuni.2016.12.012","article-title":"Neutrophils in homeostasis, immunity, and cancer","volume":"46","year":"2017","journal-title":"Immunity"},{"key":"2023080908424339600_c60","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1038\/nature12034","article-title":"Macrophage biology in development, homeostasis and disease","volume":"496","year":"2013","journal-title":"Nature"},{"key":"2023080908424339600_c61","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1038\/nri2528","article-title":"Trophic macrophages in development and disease","volume":"9","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"2023080908424339600_c62","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1016\/j.immuni.2016.02.015","article-title":"Macrophages in tissue repair, regeneration, and fibrosis","volume":"44","year":"2016","journal-title":"Immunity"},{"key":"2023080908424339600_c63","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1146\/annurev-physiol-022516-034339","article-title":"Macrophage polarization","volume":"79","year":"2017","journal-title":"Annu. Rev. Physiol."},{"key":"2023080908424339600_c64","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.immuni.2014.06.008","article-title":"Macrophage activation and polarization: Nomenclature and experimental guidelines","volume":"41","year":"2014","journal-title":"Immunity"},{"key":"2023080908424339600_c65","doi-asserted-by":"publisher","first-page":"2213","DOI":"10.1007\/s10439-019-02302-4","article-title":"Mechano-immunomodulation: Mechanoresponsive changes in macrophage activity and polarization","volume":"47","year":"2019","journal-title":"Ann. Biomed. Eng."},{"key":"2023080908424339600_c66","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1242\/dmm.004077","article-title":"Remodeling and homeostasis of the extracellular matrix: Implications for fibrotic diseases and cancer","volume":"4","year":"2011","journal-title":"Dis. Model. Mech."},{"key":"2023080908424339600_c67","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1242\/jcs.191742","article-title":"Tissue mechanics regulate brain development, homeostasis and disease","volume":"130","year":"2017","journal-title":"J. Cell Sci."},{"key":"2023080908424339600_c68","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1038\/nri3520","article-title":"Macrophages in atherosclerosis: A dynamic balance","volume":"13","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"2023080908424339600_c69","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1038\/nrcardio.2014.173","article-title":"Macrophage subsets in atherosclerosis","volume":"12","year":"2015","journal-title":"Nat. Rev. Cardiol."},{"key":"2023080908424339600_c70","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/nri3600","article-title":"Alveolar macrophages: Plasticity in a tissue-specific context","volume":"14","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"2023080908424339600_c71","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.it.2015.11.008","article-title":"Neutrophils in the tumor microenvironment","volume":"37","year":"2016","journal-title":"Trends Immunol."},{"key":"2023080908424339600_c72","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/s41577-019-0141-8","article-title":"Heterogeneity of neutrophils","volume":"19","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"2023080908424339600_c73","doi-asserted-by":"publisher","first-page":"15696","DOI":"10.1073\/pnas.0811261106","article-title":"The regulatory role of cell mechanics for migration of differentiating myeloid cells","volume":"106","year":"2009","journal-title":"Proc. Natl. Acad. Sci."},{"key":"2023080908424339600_c74","doi-asserted-by":"publisher","first-page":"e45237","DOI":"10.1371\/journal.pone.0045237","article-title":"Viscoelastic properties of differentiating blood cells are fate- and function-dependent","volume":"7","year":"2012","journal-title":"PLoS One"},{"key":"2023080908424339600_c75","doi-asserted-by":"publisher","first-page":"2181","DOI":"10.1016\/j.bpj.2015.03.047","article-title":"Human primary immune cells exhibit distinct mechanical properties that are modified by inflammation","volume":"108","year":"2015","journal-title":"Biophys. J."},{"key":"2023080908424339600_c76","doi-asserted-by":"publisher","first-page":"3508","DOI":"10.1529\/biophysj.106.088831","article-title":"Rheology of passive and adhesion-activated neutrophils probed by atomic force microscopy","volume":"91","year":"2006","journal-title":"Biophys. J."},{"key":"2023080908424339600_c77","doi-asserted-by":"publisher","first-page":"e41024","DOI":"10.1371\/journal.pone.0041024","article-title":"Cell elasticity determines macrophage function","volume":"7","year":"2012","journal-title":"PLoS One"},{"key":"2023080908424339600_c78","doi-asserted-by":"publisher","first-page":"4308","DOI":"10.1016\/j.bpj.2009.02.037","article-title":"Microfluidic investigation reveals distinct roles for actin cytoskeleton and myosin II activity in capillary leukocyte trafficking","volume":"96","year":"2009","journal-title":"Biophys. J."},{"key":"2023080908424339600_c79","doi-asserted-by":"publisher","first-page":"5702","DOI":"10.1038\/s41598-019-42180-3","article-title":"Acoustic tweezing cytometry for mechanical phenotyping of macrophages and mechanopharmaceutical cytotripsy","volume":"9","year":"2019","journal-title":"Sci. Rep."},{"key":"2023080908424339600_c80","doi-asserted-by":"publisher","first-page":"jcs236471","DOI":"10.1242\/jcs.236471","article-title":"Reactive oxygen species-mediated cytoplasmic stiffening impairs the phagocytic ability of the macrophage","volume":"133","year":"2020","journal-title":"J. Cell Sci."},{"key":"2023080908424339600_c81","doi-asserted-by":"publisher","first-page":"e60989","DOI":"10.1371\/journal.pone.0060989","article-title":"Effects of microparticle size and Fc density on macrophage phagocytosis","volume":"8","year":"2013","journal-title":"PLoS One"},{"key":"2023080908424339600_c82","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/j.bbrc.2019.08.089","article-title":"Sialylation status and mechanical properties of THP-1 macrophages upon LPS stimulation","volume":"518","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2023080908424339600_c83","doi-asserted-by":"publisher","first-page":"e1602536","DOI":"10.1126\/sciadv.1602536","article-title":"Mechanical deformation induces depolarization of neutrophils","volume":"3","year":"2017","journal-title":"Sci. Adv."},{"key":"2023080908424339600_c84","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1002\/JLB.MA0718-295RR","article-title":"Real-time deformability cytometry reveals sequential contraction and expansion during neutrophil priming","volume":"105","year":"2019","journal-title":"J. Leukocyte Biol."},{"key":"2023080908424339600_c85","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jdermsci.2011.01.005","article-title":"Hemidesmosomes and focal contact proteins: Functions and cross-talk in keratinocytes, bullous diseases and wound healing","volume":"62","year":"2011","journal-title":"J. Dermatol. Sci."},{"key":"2023080908424339600_c86","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1002\/jcp.21237","article-title":"Cell\u2013matrix adhesion","volume":"213","year":"2007","journal-title":"J. Cell. Physiol."},{"key":"2023080908424339600_c87","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/nrm2593","article-title":"Environmental sensing through focal adhesions","volume":"10","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2023080908424339600_c88","doi-asserted-by":"publisher","first-page":"4638","DOI":"10.1529\/biophysj.105.080382","article-title":"Spreading of neutrophils: From activation to migration","volume":"91","year":"2006","journal-title":"Biophys. J."},{"key":"2023080908424339600_c89","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/j.bpj.2015.05.041","article-title":"Protrusive and contractile forces of spreading human neutrophils","volume":"109","year":"2015","journal-title":"Biophys. J."},{"key":"2023080908424339600_c90","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1007\/s10544-015-9998-x","article-title":"Integrin associated proteins differentially regulate neutrophil polarity and directed migration in 2D and 3D","volume":"17","year":"2015","journal-title":"Biomed. Microdev."},{"key":"2023080908424339600_c91","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1038\/nrm1436","article-title":"Foot and mouth: Podosomes, invadopodia and circular dorsal ruffles","volume":"5","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2023080908424339600_c92","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/s00018-014-1731-z","article-title":"Tools of the trade: Podosomes as multipurpose organelles of monocytic cells","volume":"72","year":"2015","journal-title":"Cell. Mol. Life Sci."},{"key":"2023080908424339600_c93","doi-asserted-by":"publisher","first-page":"jcs236828","DOI":"10.1242\/jcs.236828","article-title":"Probing the mechanical landscape \u2013 new insights into podosome architecture and mechanics","volume":"132","year":"2019","journal-title":"J. Cell Sci."},{"key":"2023080908424339600_c94","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1038\/nature09621","article-title":"Nanoscale architecture of integrin-based cell adhesions","volume":"468","year":"2010","journal-title":"Nature"},{"key":"2023080908424339600_c95","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1038\/nrm3141","article-title":"The \u2018ins\u2019 and \u2018outs\u2019 of podosomes and invadopodia: Characteristics, formation and function","volume":"12","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2023080908424339600_c96","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.imlet.2017.05.014","article-title":"The role of CR3 (CD11b\/CD18) and CR4 (CD11c\/CD18) in complement-mediated phagocytosis and podosome formation by human phagocytes","volume":"189","year":"2017","journal-title":"Immunol. Lett."},{"key":"2023080908424339600_c97","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1016\/j.ejcb.2012.07.002","article-title":"Blood leukocytes and macrophages of various phenotypes have distinct abilities to form podosomes and to migrate in 3D environments","volume":"91","year":"2012","journal-title":"Eur. J. Cell Biol."},{"key":"2023080908424339600_c98","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.tcb.2011.10.001","article-title":"Biomechanical regulation of contractility: Spatial control and dynamics","volume":"22","year":"2012","journal-title":"Trends Cell Biol."},{"key":"2023080908424339600_c99","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1038\/nrm4012","article-title":"Forcing cells into shape: The mechanics of actomyosin contractility","volume":"16","year":"2015","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2023080908424339600_c100","doi-asserted-by":"publisher","first-page":"4507","DOI":"10.1038\/s41467-019-12304-4","article-title":"DNA mechanotechnology reveals that integrin receptors apply pN forces in podosomes on fluid substrates","volume":"10","year":"2019","journal-title":"Nat. Commun."},{"key":"2023080908424339600_c101","doi-asserted-by":"publisher","first-page":"4028","DOI":"10.1021\/acsnano.7b00622","article-title":"Podosome force generation machinery: A local balance between protrusion at the core and traction at the ring","volume":"11","year":"2017","journal-title":"ACS Nano"},{"key":"2023080908424339600_c102","doi-asserted-by":"publisher","first-page":"21016","DOI":"10.1073\/pnas.1007835107","article-title":"Dynamics of podosome stiffness revealed by atomic force microscopy","volume":"107","year":"2010","journal-title":"Proc. Natl. Acad. Sci."},{"key":"2023080908424339600_c103","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.ymeth.2015.09.002","article-title":"Evaluation of the force and spatial dynamics of macrophage podosomes by multi-particle tracking","volume":"94","year":"2016","journal-title":"Methods"},{"key":"2023080908424339600_c104","doi-asserted-by":"publisher","first-page":"1889","DOI":"10.1007\/s00018-011-0908-y","article-title":"Geometry sensing by dendritic cells dictates spatial organization and PGE2-induced dissolution of podosomes","volume":"69","year":"2012","journal-title":"Cell. Mol. Life Sci."},{"key":"2023080908424339600_c105","doi-asserted-by":"publisher","first-page":"5171","DOI":"10.1038\/s41467-019-13123-3","article-title":"Modular actin nano-architecture enables podosome protrusion and mechanosensing","volume":"10","year":"2019","journal-title":"Nat. Commun."},{"key":"2023080908424339600_c106","doi-asserted-by":"publisher","first-page":"5343","DOI":"10.1038\/ncomms6343","article-title":"Protrusion force microscopy reveals oscillatory force generation and mechanosensing activity of human macrophage podosomes","volume":"5","year":"2014","journal-title":"Nat. Commun."},{"key":"2023080908424339600_c107","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1182\/blood-2009-12-257089","article-title":"KIF5B and KIF3A\/KIF3B kinesins drive MT1-MMP surface exposure, CD44 shedding, and extracellular matrix degradation in primary macrophages","volume":"116","year":"2010","journal-title":"Blood"},{"key":"2023080908424339600_c108","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.actbio.2015.01.036","article-title":"Reduced immune cell responses on nano and submicron rough titanium","volume":"16","year":"2015","journal-title":"Acta Biomater."},{"key":"2023080908424339600_c109","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1002\/jbm.a.31863","article-title":"Cytokine profiling using monocytes\/macrophages cultured on common biomaterials with a range of surface chemistries","volume":"88A","year":"2009","journal-title":"J. Biomed. Mater. Res., Part A"},{"key":"2023080908424339600_c110","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1016\/j.imbio.2016.06.010","article-title":"The impact of surface chemistry modification on macrophage polarisation","volume":"221","year":"2016","journal-title":"Immunobiology"},{"key":"2023080908424339600_c111","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1002\/cm.20130","article-title":"Sensitivity of alveolar macrophages to substrate mechanical and adhesive properties","volume":"63","year":"2006","journal-title":"Cell Motil."},{"key":"2023080908424339600_c112","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1163\/156856208786052407","article-title":"Modulus-dependent macrophage adhesion and behavior","volume":"19","year":"2008","journal-title":"J. Biomater. Sci., Polym. Ed."},{"key":"2023080908424339600_c113","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.yexcr.2018.04.005","article-title":"Reduced substrate stiffness promotes M2-like macrophage activation and enhances peroxisome proliferator-activated receptor \u03b3 expression","volume":"367","year":"2018","journal-title":"Exp. Cell Res."},{"key":"2023080908424339600_c114","doi-asserted-by":"publisher","first-page":"383","DOI":"10.3389\/fimmu.2019.00383","article-title":"Shear and dynamic compression modulates the inflammatory phenotype of human monocytes in vitro","volume":"10","year":"2019","journal-title":"Front. Immunol."},{"key":"2023080908424339600_c115","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1243\/0954411011536073","article-title":"A novel three-dimensional tissue equivalent model to study the combined effects of cyclic mechanical strain and wear particles on the osteolytic potential of primary human macrophages in vitro","volume":"215","year":"2016","journal-title":"Proc. Inst. Mech. Eng., Part H"},{"key":"2023080908424339600_c116","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.actbio.2016.09.024","article-title":"Differential regulation of macrophage inflammatory activation by fibrin and fibrinogen","volume":"47","year":"2017","journal-title":"Acta Biomater."},{"key":"2023080908424339600_c117","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1021\/acsbiomaterials.8b00910","article-title":"Macrophage polarization in response to collagen scaffold stiffness is dependent on cross-linking agent used to modulate the stiffness","volume":"5","year":"2019","journal-title":"ACS Biomater. Sci. Eng."},{"key":"2023080908424339600_c118","doi-asserted-by":"publisher","first-page":"4213","DOI":"10.1242\/jcs.151167","article-title":"A crucial role for \u03b22 integrins in podosome formation, dynamics and Toll-like-receptor-signaled disassembly in dendritic cells","volume":"127","year":"2014","journal-title":"J. Cell Sci."},{"key":"2023080908424339600_c119","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s42003-020-0843-2","article-title":"Podosome formation promotes plasma membrane invagination and integrin-\u03b23 endocytosis on a viscous RGD-membrane","volume":"3","year":"2020","journal-title":"Commun. Biol."},{"key":"2023080908424339600_c120","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1002\/jbm.a.10516","article-title":"Monocyte\/macrophage interactions with base and linear- and star-like PEG-modified PEG-poly(acrylic acid) co-polymers","volume":"66A","year":"2003","journal-title":"J. Biomed. Mater. Res., Part A"},{"key":"2023080908424339600_c121","doi-asserted-by":"publisher","first-page":"5978","DOI":"10.1021\/acsnano.8b02226","article-title":"Magnetic manipulation of reversible nanocaging controls in vivo adhesion and polarization of macrophages","volume":"12","year":"2018","journal-title":"ACS Nano"},{"key":"2023080908424339600_c122","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1038\/s41467-019-09733-6","article-title":"Immunoregulation of macrophages by dynamic ligand presentation via ligand\u2013cation coordination","volume":"10","year":"2019","journal-title":"Nat. Commun."},{"key":"2023080908424339600_c123","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1007\/s40883-018-0065-z","article-title":"Regulation of macrophages by extracellular matrix composition and adhesion geometry","volume":"4","year":"2018","journal-title":"Regener. Eng. Transl. Med."},{"key":"2023080908424339600_c124","doi-asserted-by":"publisher","first-page":"3599","DOI":"10.1039\/c0sm01353f","article-title":"Human macrophage adhesion on polysaccharide patterned surfaces","volume":"7","year":"2011","journal-title":"Soft Matter"},{"key":"2023080908424339600_c125","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1002\/jbm.a.34309","article-title":"Correlating macrophage morphology and cytokine production resulting from biomaterial contact","volume":"101A","year":"2013","journal-title":"J. Biomed. Mater. Res., Part A"},{"key":"2023080908424339600_c126","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.neuroscience.2018.02.015","article-title":"Biomaterial cues to direct a pro-regenerative phenotype in macrophages and Schwann cells","volume":"376","year":"2018","journal-title":"Neuroscience"},{"key":"2023080908424339600_c127","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1146\/annurev-pathol-012414-040418","article-title":"Engineered in vitro disease models","volume":"10","year":"2015","journal-title":"Annu. Rev. Pathol. Mech. Dis."},{"key":"2023080908424339600_c128","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1007\/s10409-015-0412-y","article-title":"Cell biomechanics and its applications in human disease diagnosis","volume":"31","year":"2015","journal-title":"Acta Mech. Sin."},{"key":"2023080908424339600_c129","doi-asserted-by":"publisher","first-page":"40","DOI":"10.3389\/fbioe.2017.00040","article-title":"Tissue engineering approaches in the design of healthy and pathological in vitro tissue models","volume":"5","year":"2017","journal-title":"Front. Bioeng. Biotechnol."},{"key":"2023080908424339600_c130","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/s41578-018-0023-x","article-title":"Extracellular matrix-based materials for regenerative medicine","volume":"3","year":"2018","journal-title":"Nat. Rev. Mater."},{"key":"2023080908424339600_c131","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1016\/j.tibtech.2018.03.011","article-title":"Inflammation-on-a-chip: Probing the immune system ex vivo","volume":"36","year":"2018","journal-title":"Trends Biotechnol."},{"key":"2023080908424339600_c132","doi-asserted-by":"publisher","first-page":"1700254","DOI":"10.1002\/smtd.201700254","article-title":"Biochips\u2014New platforms for cell-based immunological assays","volume":"2","year":"2018","journal-title":"Small Methods"},{"key":"2023080908424339600_c133","doi-asserted-by":"publisher","first-page":"1801406","DOI":"10.1002\/adhm.201801406","article-title":"Analysis of leukocyte behaviors on microfluidic chips","volume":"8","year":"2019","journal-title":"Adv. Healthcare Mater."},{"key":"2023080908424339600_c134","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1186\/s12967-020-02335-7","article-title":"Microfluidic devices for neutrophil chemotaxis studies","volume":"18","year":"2020","journal-title":"J. Transl. Med."},{"key":"2023080908424339600_c135","doi-asserted-by":"publisher","first-page":"13349","DOI":"10.1073\/pnas.0705889104","article-title":"Bound attractant at the leading vs. the trailing edge determines chemotactic prowess","volume":"104","year":"2007","journal-title":"Proc. Natl. Acad. Sci."},{"key":"2023080908424339600_c136","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1039\/B913494H","article-title":"A new method for studying gradient-induced neutrophil desensitization based on an open microfluidic chamber","volume":"10","year":"2010","journal-title":"Lab Chip"},{"key":"2023080908424339600_c137","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1039\/C4LC00970C","article-title":"A neutrophil treadmill to decouple spatial and temporal signals during chemotaxis","volume":"15","year":"2015","journal-title":"Lab. Chip"},{"key":"2023080908424339600_c138","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1038\/nbt712","article-title":"Neutrophil chemotaxis in linear and complex gradients of interleukin-8 formed in a microfabricated device","volume":"20","year":"2002","journal-title":"Nat. Biotechnol."},{"key":"2023080908424339600_c139","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1039\/B511877H","article-title":"Microfluidic system for measuring neutrophil migratory responses to fast switches of chemical gradients","volume":"6","year":"2006","journal-title":"Lab Chip"},{"key":"2023080908424339600_c140","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1039\/c0ib00011f","article-title":"Directional decisions during neutrophil chemotaxis inside bifurcating channels","volume":"2","year":"2010","journal-title":"Integr. Biol. Quant. Biosci. Nano Macro"},{"key":"2023080908424339600_c141","doi-asserted-by":"publisher","first-page":"e85726","DOI":"10.1371\/journal.pone.0085726","article-title":"Oscillatory behavior of neutrophils under opposing chemoattractant gradients supports a winner-take-all mechanism","volume":"9","year":"2014","journal-title":"PLoS One"},{"key":"2023080908424339600_c142","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1039\/C3LC50959A","article-title":"On-demand, competing gradient arrays for neutrophil chemotaxis","volume":"14","year":"2014","journal-title":"Lab Chip"},{"key":"2023080908424339600_c143","doi-asserted-by":"publisher","first-page":"0094","DOI":"10.1038\/s41551-017-0094","article-title":"Microscale arrays for the profiling of start and stop signals coordinating human-neutrophil swarming","volume":"1","year":"2017","journal-title":"Nat. Biomed. Eng."},{"key":"2023080908424339600_c144","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1039\/C5IB00265F","article-title":"Capillary plexuses are vulnerable to neutrophil extracellular traps","volume":"8","year":"2016","journal-title":"Integr. Biol."},{"key":"2023080908424339600_c145","doi-asserted-by":"publisher","first-page":"2003","DOI":"10.1039\/C7LC00356K","article-title":"Thermal scribing to prototype plastic microfluidic devices, applied to study the formation of neutrophil extracellular traps","volume":"17","year":"2017","journal-title":"Lab Chip"},{"key":"2023080908424339600_c146","doi-asserted-by":"publisher","first-page":"16983","DOI":"10.1038\/s41598-018-34952-0","article-title":"Microfluidic assay measures increased neutrophil extracellular traps circulating in","volume":"8","year":"2018","journal-title":"Sci. Rep."},{"key":"2023080908424339600_c147","doi-asserted-by":"publisher","first-page":"e7104","DOI":"10.1371\/journal.pone.0007104","article-title":"Determinants of leukocyte margination in rectangular microchannels","volume":"4","year":"2009","journal-title":"PLoS One"},{"key":"2023080908424339600_c148","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1038\/nmeth.1508","article-title":"Quantitative dynamic footprinting microscopy reveals mechanisms of neutrophil rolling","volume":"7","year":"2010","journal-title":"Nat. Methods"},{"key":"2023080908424339600_c149","doi-asserted-by":"publisher","first-page":"472","DOI":"10.4049\/jimmunol.1004197","article-title":"Migrational guidance of neutrophils is mechanotransduced via high-affinity LFA-1 and calcium flux","volume":"187","year":"2011","journal-title":"J. Immunol."},{"key":"2023080908424339600_c150","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1038\/nature11248","article-title":"\u2018Slings\u2019 enable neutrophil rolling at high shear","volume":"488","year":"2012","journal-title":"Nature"},{"key":"2023080908424339600_c151","doi-asserted-by":"publisher","first-page":"28870","DOI":"10.1038\/srep28870","article-title":"Microfluidics-based side view flow chamber reveals tether-to-sling transition in rolling neutrophils","volume":"6","year":"2016","journal-title":"Sci. Rep."},{"key":"2023080908424339600_c152","doi-asserted-by":"publisher","first-page":"013409","DOI":"10.1063\/1.3530598","article-title":"A microfluidic membrane device to mimic critical components of the vascular microenvironment","volume":"5","year":"2011","journal-title":"Biomicrofluidics"},{"key":"2023080908424339600_c153","first-page":"15","article-title":"Boyden chamber assay","volume-title":"Cell Migration: Developmental Methods and Protocols","author":"Guan","year":"2005"},{"key":"2023080908424339600_c154","doi-asserted-by":"publisher","first-page":"3861","DOI":"10.1039\/c2lc40445a","article-title":"A versatile assay for monitoring in vivo-like transendothelial migration of neutrophils","volume":"12","year":"2012","journal-title":"Lab Chip"},{"key":"2023080908424339600_c155","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1016\/j.bbagen.2017.02.012","article-title":"A versatile microfluidic platform for the study of cellular interactions between endothelial cells and neutrophils","volume":"1861","year":"2017","journal-title":"Biochim. Biophys. Acta BBA"},{"key":"2023080908424339600_c156","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.biomaterials.2018.03.005","article-title":"The effects of monocytes on tumor cell extravasation in a 3D vascularized microfluidic model","volume":"198","year":"2019","journal-title":"Biomaterials"},{"key":"2023080908424339600_c157","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1529\/biophysj.107.119156","article-title":"Mechanical forces induced by the transendothelial migration of human neutrophils","volume":"95","year":"2008","journal-title":"Biophys. J."},{"key":"2023080908424339600_c158","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1007\/s12195-010-0105-3","article-title":"Mechanical forces in endothelial cells during firm adhesion and early transmigration of human monocytes","volume":"3","year":"2010","journal-title":"Cell. Mol. Bioeng."},{"key":"2023080908424339600_c159","doi-asserted-by":"publisher","first-page":"e61377","DOI":"10.1371\/journal.pone.0061377","article-title":"Human neutrophil cytoskeletal dynamics and contractility actively contribute to trans-endothelial migration","volume":"8","year":"2013","journal-title":"PLoS One"},{"key":"2023080908424339600_c160","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1073\/pnas.1717489115","article-title":"Three-dimensional forces exerted by leukocytes and vascular endothelial cells dynamically facilitate diapedesis","volume":"115","year":"2018","journal-title":"Proc. Natl. Acad. Sci."},{"key":"2023080908424339600_c161","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/nmeth.3839","article-title":"A practical guide to hydrogels for cell culture","volume":"13","year":"2016","journal-title":"Nat. Methods"},{"key":"2023080908424339600_c162","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.devcel.2016.06.031","article-title":"Leading from the back: The role of the uropod in neutrophil polarization and migration","volume":"38","year":"2016","journal-title":"Dev. Cell"},{"key":"2023080908424339600_c163","doi-asserted-by":"publisher","first-page":"L58","DOI":"10.1529\/biophysj.106.102822","article-title":"Neutrophil traction stresses are concentrated in the uropod during migration","volume":"92","year":"2007","journal-title":"Biophys. J."},{"key":"2023080908424339600_c164","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1182\/blood-2008-11-191445","article-title":"Neutrophil morphology and migration are affected by substrate elasticity","volume":"114","year":"2009","journal-title":"Blood"},{"key":"2023080908424339600_c165","doi-asserted-by":"publisher","first-page":"194117","DOI":"10.1088\/0953-8984\/22\/19\/194117","article-title":"Neutrophil adhesion and chemotaxis depend on substrate mechanics","volume":"22","year":"2010","journal-title":"J. Phys."},{"key":"2023080908424339600_c166","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/j.bpj.2011.05.040","article-title":"Traction forces of neutrophils migrating on compliant substrates","volume":"101","year":"2011","journal-title":"Biophys. J."},{"key":"2023080908424339600_c167","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.actbio.2019.02.048","article-title":"Material stiffness influences the polarization state, function and migration mode of macrophages","volume":"89","year":"2019","journal-title":"Acta Biomater."},{"key":"2023080908424339600_c168","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1039\/C4IB00260A","article-title":"Macrophage motility is driven by frontal-towing with a force magnitude dependent on substrate stiffness","volume":"7","year":"2015","journal-title":"Integr. Biol."},{"key":"2023080908424339600_c169","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1007\/s10439-014-1142-1","article-title":"Lipid rafts direct macrophage motility in the tissue microenvironment","volume":"43","year":"2015","journal-title":"Ann. Biomed. Eng."},{"key":"2023080908424339600_c170","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1007\/s12195-016-0435-x","article-title":"Effect of M1\u2013M2 polarization on the motility and traction stresses of primary human macrophages","volume":"9","year":"2016","journal-title":"Cell. Mol. Bioeng."},{"key":"2023080908424339600_c171","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/1742-2094-8-58","article-title":"Classically and alternatively activated bone marrow derived macrophages differ in cytoskeletal functions and migration towards specific CNS cell types","volume":"8","year":"2011","journal-title":"J. Neuroinflammation"},{"key":"2023080908424339600_c172","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/1742-2094-11-23","article-title":"Macrophages migrate in an activation-dependent manner to chemokines involved in neuroinflammation","volume":"11","year":"2014","journal-title":"J. Neuroinflammation"},{"key":"2023080908424339600_c173","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1182\/blood-2009-04-218735","article-title":"Three-dimensional migration of macrophages requires Hck for podosome organization and extracellular matrix proteolysis","volume":"115","year":"2010","journal-title":"Blood"},{"key":"2023080908424339600_c174","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.4049\/jimmunol.0902223","article-title":"Matrix architecture dictates three-dimensional migration modes of human macrophages: Differential involvement of proteases and podosome-like structures","volume":"184","year":"2010","journal-title":"J. Immunol."},{"key":"2023080908424339600_c175","doi-asserted-by":"publisher","first-page":"4009","DOI":"10.1242\/jcs.150987","article-title":"Rho\/ROCK pathway inhibition by the CDK inhibitor p27kip1 participates in the onset of macrophage 3D-mesenchymal migration","volume":"127","year":"2014","journal-title":"J. Cell Sci."},{"key":"2023080908424339600_c176","doi-asserted-by":"publisher","first-page":"02650","DOI":"10.3389\/fimmu.2018.02650","article-title":"Distinct migratory properties of M1, M2, and resident macrophages are regulated by \u03b1D\u03b22 and \u03b1M\u03b22 integrin-mediated adhesion","volume":"9","year":"2018","journal-title":"Front. Immunol."},{"key":"2023080908424339600_c177","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1111\/imr.12214","article-title":"Control of macrophage 3D migration: A therapeutic challenge to limit tissue infiltration","volume":"262","year":"2014","journal-title":"Immunol. Rev."},{"key":"2023080908424339600_c178","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.immuni.2005.05.002","article-title":"Phagocytosis: Elegant complexity","volume":"22","year":"2005","journal-title":"Immunity"},{"key":"2023080908424339600_c179","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1038\/nri3244","article-title":"Information processing during phagocytosis","volume":"12","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"2023080908424339600_c180","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1083\/jcb.201007056","article-title":"Dynamic macrophage \u2018probing\u2019 is required for the efficient capture of phagocytic targets","volume":"191","year":"2010","journal-title":"J. Cell Biol."},{"key":"2023080908424339600_c181","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/s00249-006-0118-y","article-title":"Micromechanics of filopodia mediated capture of pathogens by macrophages","volume":"36","year":"2007","journal-title":"Eur. Biophys. J."},{"key":"2023080908424339600_c182","doi-asserted-by":"publisher","first-page":"2884","DOI":"10.1038\/srep02884","article-title":"Macrophages lift off surface-bound bacteria using a filopodium-lamellipodium hook-and-shovel mechanism","volume":"3","year":"2013","journal-title":"Sci. Rep."},{"key":"2023080908424339600_c183","doi-asserted-by":"publisher","first-page":"aah6094","DOI":"10.1126\/scirobotics.aah6094","article-title":"Robotically controlled microprey to resolve initial attack modes preceding phagocytosis","volume":"2","year":"2017","journal-title":"Sci. Rob."},{"key":"2023080908424339600_c184","doi-asserted-by":"publisher","first-page":"11633","DOI":"10.1073\/pnas.0702449104","article-title":"Filopodia act as phagocytic tentacles and pull with discrete steps and a load-dependent velocity","volume":"104","year":"2007","journal-title":"Proc. Natl. Acad. Sci."},{"key":"2023080908424339600_c185","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1242\/jcs.00230","article-title":"Local force induced conical protrusions of phagocytic cells","volume":"116","year":"2003","journal-title":"J. Cell Sci."},{"key":"2023080908424339600_c186","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1039\/C5NH00049A","article-title":"Nanoscale adhesion forces between the fungal pathogen Candida albicans and macrophages","volume":"1","year":"2016","journal-title":"Nanoscale Horiz."},{"key":"2023080908424339600_c187","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1242\/jcs.00235","article-title":"Phosphoinositide-3-kinase-independent contractile activities associated with Fc\u03b3-receptor-mediated phagocytosis and macropinocytosis in macrophages","volume":"116","year":"2003","journal-title":"J. Cell Sci."},{"key":"2023080908424339600_c188","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1242\/jcs.112.3.307","article-title":"A contractile activity that closes phagosomes in macrophages","volume":"112","year":"1999","journal-title":"J. Cell Sci."},{"key":"2023080908424339600_c189","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1083\/jcb.122.6.1295","article-title":"Synchrony of cell spreading and contraction force as phagocytes engulf large pathogens","volume":"122","year":"1993","journal-title":"J. Cell Biol."},{"key":"2023080908424339600_c190","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1242\/jcs.02275","article-title":"Mechanics of neutrophil phagocytosis: Behavior of the cortical tension","volume":"118","year":"2005","journal-title":"J. Cell Sci."},{"key":"2023080908424339600_c191","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.tcb.2019.11.002","article-title":"Squeezing in a meal: Myosin functions in phagocytosis","volume":"30","year":"2019","journal-title":"Trends Cell Biol."},{"key":"2023080908424339600_c192","doi-asserted-by":"publisher","first-page":"11875","DOI":"10.1073\/pnas.1301766110","article-title":"Plasma membrane tension orchestrates membrane trafficking, cytoskeletal remodeling, and biochemical signaling during phagocytosis","volume":"110","year":"2013","journal-title":"Proc. Natl. Acad. Sci."},{"key":"2023080908424339600_c193","doi-asserted-by":"publisher","first-page":"2698","DOI":"10.1016\/j.bpj.2016.11.009","article-title":"Frustrated phagocytic spreading of J774A-1 macrophages ends in myosin II-dependent contraction","volume":"111","year":"2016","journal-title":"Biophys. J."},{"key":"2023080908424339600_c194","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1242\/jcs.115.4.849","article-title":"Fc-receptor-mediated phagocytosis is regulated by mechanical properties of the target","volume":"115","year":"2002","journal-title":"J. Cell Sci."},{"key":"2023080908424339600_c195","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1038\/s41556-019-0414-2","article-title":"Coupling of \u03b22 integrins to actin by a mechanosensitive molecular clutch drives complement receptor-mediated phagocytosis","volume":"21","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"2023080908424339600_c196","doi-asserted-by":"publisher","first-page":"20121048","DOI":"10.1098\/rsif.2012.1048","article-title":"A method for time-resolved measurements of the mechanics of phagocytic cups","volume":"10","year":"2013","journal-title":"J. R. Soc. Interface"},{"key":"2023080908424339600_c197","article-title":"Combined atomic force microscope and volumetric light sheet system for mechanobiology","year":"2019"},{"key":"2023080908424339600_c198","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/s41467-019-13804-z","article-title":"Microparticle traction force microscopy reveals subcellular force exertion patterns in immune cell\u2013target interactions","volume":"11","year":"2020","journal-title":"Nat. Commun."},{"key":"2023080908424339600_c199","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.devcel.2019.05.028","article-title":"Dynamic podosome-like structures in nascent phagosomes are coordinated by phosphoinositides","volume":"50","year":"2019","journal-title":"Dev. Cell"},{"key":"2023080908424339600_c200","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/0304-4165(86)90020-6","article-title":"Pinocytosis and phagocytosis: The effect of size of a particulate substrate on its mode of capture by rat peritoneal macrophages cultured in vitro","volume":"881","year":"1986","journal-title":"Biochim. Biophys. Acta BBA"},{"key":"2023080908424339600_c201","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1006\/excr.1998.4110","article-title":"Size of IgG-opsonized particles determines macrophage response during internalization","volume":"242","year":"1998","journal-title":"Exp. Cell Res."},{"key":"2023080908424339600_c202","doi-asserted-by":"publisher","first-page":"3169","DOI":"10.1021\/acsnano.5b00147","article-title":"Elasticity of nanoparticles influences their blood circulation, phagocytosis, endocytosis, and targeting","volume":"9","year":"2015","journal-title":"ACS Nano"},{"key":"2023080908424339600_c203","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1021\/acsabm.8b00111","article-title":"Mechanosensitive endocytosis of high-stiffness, submicron microgels in macrophage and hepatocarcinoma cell lines","volume":"1","year":"2018","journal-title":"ACS Appl. Bio Mater."},{"key":"2023080908424339600_c204","doi-asserted-by":"publisher","first-page":"eaaz4316","DOI":"10.1126\/sciadv.aaz4316","article-title":"Nanoparticle elasticity regulates phagocytosis and cancer cell uptake","volume":"6","year":"2020","journal-title":"Sci. Adv."},{"key":"2023080908424339600_c205","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1007\/s11095-008-9562-y","article-title":"Role of particle size in phagocytosis of polymeric microspheres","volume":"25","year":"2008","journal-title":"Pharm. Res."},{"key":"2023080908424339600_c206","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1016\/j.bpj.2013.07.036","article-title":"Phagocytosis dynamics depends on target shape","volume":"105","year":"2013","journal-title":"Biophys. J."},{"key":"2023080908424339600_c207","doi-asserted-by":"publisher","first-page":"e10051","DOI":"10.1371\/journal.pone.0010051","article-title":"Macrophages recognize size and shape of their targets","volume":"5","year":"2010","journal-title":"PLoS One"},{"key":"2023080908424339600_c208","doi-asserted-by":"publisher","first-page":"4930","DOI":"10.1073\/pnas.0600997103","article-title":"Role of target geometry in phagocytosis","volume":"103","year":"2006","journal-title":"Proc. Natl. Acad. Sci."},{"key":"2023080908424339600_c209","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1007\/s11095-008-9626-z","article-title":"Shape induced inhibition of phagocytosis of polymer particles","volume":"26","year":"2009","journal-title":"Pharm. Res."},{"key":"2023080908424339600_c210","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1039\/c0md00008f","article-title":"Effect of particle shape on phagocytosis of CdTe quantum dot\u2013cystine composites","volume":"1","year":"2010","journal-title":"MedChemComm"},{"key":"2023080908424339600_c211","doi-asserted-by":"publisher","first-page":"2901","DOI":"10.1021\/nl3004896","article-title":"The race to the pole: How high-aspect ratio shape and heterogeneous environments limit phagocytosis of filamentous Escherichia coli bacteria by macrophages","volume":"12","year":"2012","journal-title":"Nano Lett."},{"key":"2023080908424339600_c212","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1083\/jcb.201304095","article-title":"Filamentous morphology of bacteria delays the timing of phagosome morphogenesis in macrophages","volume":"203","year":"2013","journal-title":"J. Cell Biol."},{"key":"2023080908424339600_c213","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/j.jconrel.2010.07.116","article-title":"Polymer particle shape independently influences binding and internalization by macrophages","volume":"147","year":"2010","journal-title":"J. Controlled Release"},{"key":"2023080908424339600_c214","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/S0168-3659(01)00549-1","article-title":"Targeting to macrophages: Role of physicochemical properties of particulate carriers\u2014liposomes and microspheres\u2014on the phagocytosis by macrophages","volume":"79","year":"2002","journal-title":"J. Controlled Release"},{"key":"2023080908424339600_c215","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1165\/rcmb.2008-0046OC","article-title":"The phagocytosis of crystalline silica particles by macrophages","volume":"39","year":"2008","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"2023080908424339600_c216","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1023\/A:1022366921298","article-title":"Ligand-specific targeting of microspheres to phagocytes by surface modification with poly(L-lysine)-grafted poly(ethylene glycol) conjugate","volume":"20","year":"2003","journal-title":"Pharm. Res."},{"key":"2023080908424339600_c217","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1021\/acsnano.7b07797","article-title":"Modulating phagocytic cell sequestration by tailoring nanoconstruct softness","volume":"12","year":"2018","journal-title":"ACS Nano"},{"key":"2023080908424339600_c218","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1182\/blood-2014-06-585299","article-title":"Cell rigidity and shape override CD47's \u2018self\u2019-signaling in phagocytosis by hyperactivating myosin-II","volume":"125","year":"2015","journal-title":"Blood"},{"key":"2023080908424339600_c219","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1002\/btm2.10047","article-title":"Tunable particles alter macrophage uptake based on combinatorial effects of physical properties","volume":"2","year":"2017","journal-title":"Bioeng. Transl. Med."},{"key":"2023080908424339600_c220","doi-asserted-by":"publisher","first-page":"e92634","DOI":"10.1371\/journal.pone.0092634","article-title":"Effect of silica particle size on macrophage inflammatory responses","volume":"9","year":"2014","journal-title":"PLoS One"},{"key":"2023080908424339600_c221","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.actbio.2019.11.021","article-title":"Biomaterial-mediated reprogramming of monocytes via microparticle phagocytosis for sustained modulation of macrophage phenotype","volume":"101","year":"2019","journal-title":"Acta Biomater."},{"key":"2023080908424339600_c222","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.jconrel.2007.03.022","article-title":"Particle shape: A new design parameter for micro- and nanoscale drug delivery carriers","volume":"121","year":"2007","journal-title":"J. Controlled Release"},{"key":"2023080908424339600_c223","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1080\/21541248.2017.1332505","article-title":"Go with the flow: GEF-H1 mediated shear stress mechanotransduction in neutrophils","volume":"11","year":"2020","journal-title":"Small GTPases"},{"key":"2023080908424339600_c224","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1091\/mbc.E16-12-0827","article-title":"Ligand-specific binding forces of LFA-1 and Mac-1 in neutrophil adhesion and crawling","volume":"29","year":"2017","journal-title":"Mol. Biol. Cell"},{"key":"2023080908424339600_c225","doi-asserted-by":"publisher","first-page":"15196","DOI":"10.1038\/ncomms15196","article-title":"L-selectin mechanochemistry restricts neutrophil priming in vivo","volume":"8","year":"2017","journal-title":"Nat. Commun."},{"key":"2023080908424339600_c226","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1002\/JLB.3A0520-100RR","article-title":"Tensile force transmitted through LFA-1 bonds mechanoregulate neutrophil inflammatory response","volume":"108","year":"2020","journal-title":"J. Leukocyte Biol."},{"key":"2023080908424339600_c227","doi-asserted-by":"publisher","first-page":"1804","DOI":"10.1016\/j.bpj.2012.03.053","article-title":"Shear-induced resistance to neutrophil activation via the formyl peptide receptor","volume":"102","year":"2012","journal-title":"Biophys. J."},{"key":"2023080908424339600_c228","doi-asserted-by":"publisher","first-page":"2243","DOI":"10.1016\/j.bpj.2014.04.001","article-title":"Fluid shear stress increases neutrophil activation via platelet-activating factor","volume":"106","year":"2014","journal-title":"Biophys. J."},{"key":"2023080908424339600_c229","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1177\/0391398818817326","article-title":"Mechanical shear stress and leukocyte phenotype and function: Implications for ventricular assist device development and use","volume":"42","year":"2019","journal-title":"Int. J. Artif. Organs"},{"key":"2023080908424339600_c230","doi-asserted-by":"publisher","first-page":"2323","DOI":"10.1152\/japplphysiol.00503.2005","article-title":"Cytoskeletal remodeling and cellular activation during deformation of neutrophils into narrow channels","volume":"99","year":"2005","journal-title":"J. Appl. Physiol."},{"key":"2023080908424339600_c231","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-017-02993-6","article-title":"haptotaxis assay for neutrophils using optical patterning and a high-content approach","volume":"7","year":"2017","journal-title":"Sci. Rep."},{"key":"2023080908424339600_c232","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.1039\/b710524j","article-title":"Polar stimulation and constrained cell migration in microfluidic channels","volume":"7","year":"2007","journal-title":"Lab Chip"},{"key":"2023080908424339600_c233","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1039\/C3IB40175H","article-title":"Retrotaxis of human neutrophils during mechanical confinement inside microfluidic channels","volume":"6","year":"2014","journal-title":"Integr. Biol."},{"key":"2023080908424339600_c234","doi-asserted-by":"publisher","first-page":"6326","DOI":"10.1021\/acs.nanolett.8b02611","article-title":"Nanoscale forces during confined cell migration","volume":"18","year":"2018","journal-title":"Nano Lett."},{"key":"2023080908424339600_c235","doi-asserted-by":"publisher","first-page":"3752","DOI":"10.1074\/jbc.M114.619643","article-title":"Matrix confinement plays a pivotal role in regulating neutrophil-generated tractions, speed, and integrin utilization","volume":"290","year":"2015","journal-title":"J. Biol. Chem."},{"key":"2023080908424339600_c236","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1039\/C4IB00245H","article-title":"Traction stress analysis and modeling reveal that amoeboid migration in confined spaces is accompanied by expansive forces and requires the structural integrity of the membrane\u2013cortex interactions","volume":"7","year":"2015","journal-title":"Integr. Biol."},{"key":"2023080908424339600_c237","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.addr.2017.05.010","article-title":"Macrophage-based therapeutic strategies in regenerative medicine","volume":"122","year":"2017","journal-title":"Adv. Drug Delivery Rev."},{"key":"2023080908424339600_c238","doi-asserted-by":"publisher","first-page":"1801332","DOI":"10.1002\/adhm.201801332","article-title":"Unraveling the mechanobiology of the immune system","volume":"8","year":"2019","journal-title":"Adv. Healthcare Mater."},{"key":"2023080908424339600_c239","doi-asserted-by":"publisher","first-page":"5497","DOI":"10.1016\/j.biomaterials.2009.07.010","article-title":"Effect of polyurethane chemistry and protein coating on monocyte differentiation towards a wound healing phenotype macrophage","volume":"30","year":"2009","journal-title":"Biomaterials"},{"key":"2023080908424339600_c240","doi-asserted-by":"publisher","first-page":"8316","DOI":"10.1016\/j.biomaterials.2012.08.014","article-title":"Protein binding mediation of biomaterial-dependent monocyte activation on a degradable polar hydrophobic ionic polyurethane","volume":"33","year":"2012","journal-title":"Biomaterials"},{"key":"2023080908424339600_c241","doi-asserted-by":"publisher","first-page":"2843","DOI":"10.1016\/S0142-9612(03)00097-8","article-title":"Adhesion, apoptosis and cytokine release of human mononuclear cells cultured on degradable poly(urethane urea), polystyrene and titanium in vitro","volume":"24","year":"2003","journal-title":"Biomaterials"},{"key":"2023080908424339600_c242","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/j.actbio.2013.10.035","article-title":"Impact of 3-D printed PLA- and chitosan-based scaffolds on human monocyte\/macrophage responses: Unraveling the effect of 3-D structures on inflammation","volume":"10","year":"2014","journal-title":"Acta Biomater."},{"key":"2023080908424339600_c243","doi-asserted-by":"publisher","first-page":"4136","DOI":"10.1016\/j.biomaterials.2012.02.050","article-title":"Inducing healing-like human primary macrophage phenotypes by 3D hydrogel coated nanofibres","volume":"33","year":"2012","journal-title":"Biomaterials"},{"key":"2023080908424339600_c244","doi-asserted-by":"publisher","first-page":"1700289","DOI":"10.1002\/adhm.201700289","article-title":"Integrin-mediated interactions control macrophage polarization in 3D hydrogels","volume":"6","year":"2017","journal-title":"Adv. Healthcare Mater."},{"key":"2023080908424339600_c245","doi-asserted-by":"publisher","first-page":"1600967","DOI":"10.1002\/adhm.201600967","article-title":"Instructing human macrophage polarization by stiffness and glycosaminoglycan functionalization in 3D collagen networks","volume":"6","year":"2017","journal-title":"Adv. Healthcare Mater."},{"key":"2023080908424339600_c246","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.biomaterials.2019.04.018","article-title":"3D type I collagen environment leads up to a reassessment of the classification of human macrophage polarizations","volume":"208","year":"2019","journal-title":"Biomaterials"},{"key":"2023080908424339600_c247","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1002\/jbm.a.35700","article-title":"The effect of chemically modified alginates on macrophage phenotype and biomolecule transport","volume":"104","year":"2016","journal-title":"J. Biomed. Mater. Res., Part A"},{"key":"2023080908424339600_c248","doi-asserted-by":"publisher","first-page":"1700707","DOI":"10.1002\/adhm.201700707","article-title":"Incorporation of a ligand peptide for immune inhibitory receptor LAIR-1 on biomaterial surfaces inhibits macrophage inflammatory responses","volume":"6","year":"2017","journal-title":"Adv. Healthcare Mater."},{"key":"2023080908424339600_c249","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1002\/adhm.201300532","article-title":"Modification of biomaterials with a self-protein inhibits the macrophage response","volume":"3","year":"2014","journal-title":"Adv. Healthcare Mater."},{"key":"2023080908424339600_c250","doi-asserted-by":"publisher","first-page":"17253","DOI":"10.1073\/pnas.1308887110","article-title":"Modulation of macrophage phenotype by cell shape","volume":"110","year":"2013","journal-title":"Proc. Natl. Acad. Sci."},{"key":"2023080908424339600_c251","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1038\/s41563-018-0190-6","article-title":"Spatial confinement downsizes the inflammatory response of macrophages","volume":"17","year":"2018","journal-title":"Nat. Mater."},{"key":"2023080908424339600_c252","doi-asserted-by":"publisher","first-page":"9853","DOI":"10.1016\/j.biomaterials.2014.08.025","article-title":"Improved implant osseointegration of a nanostructured titanium surface via mediation of macrophage polarization","volume":"35","year":"2014","journal-title":"Biomaterials"},{"key":"2023080908424339600_c253","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.actbio.2015.12.003","article-title":"Titanium surface characteristics, including topography and wettability, alter macrophage activation","volume":"31","year":"2016","journal-title":"Acta Biomater."},{"key":"2023080908424339600_c254","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1002\/jbm.a.30075","article-title":"Effect of titanium surface topography on macrophage activation and secretion of proinflammatory cytokines and chemokines","volume":"70A","year":"2004","journal-title":"J. Biomed. Mater. Res., Part A"},{"key":"2023080908424339600_c255","doi-asserted-by":"publisher","first-page":"5170","DOI":"10.1016\/j.biomaterials.2006.05.002","article-title":"The role of titanium surface topography on J774A.1 macrophage inflammatory cytokines and nitric oxide production","volume":"27","year":"2006","journal-title":"Biomaterials"},{"key":"2023080908424339600_c256","doi-asserted-by":"publisher","first-page":"2337","DOI":"10.1016\/j.actbio.2011.01.006","article-title":"Analysis on migration and activation of live macrophages on transparent flat and nanostructured titanium","volume":"7","year":"2011","journal-title":"Acta Biomater."},{"key":"2023080908424339600_c257","doi-asserted-by":"publisher","first-page":"28665","DOI":"10.1021\/acsami.5b10589","article-title":"Micro- and nanopatterned topographical cues for regulating macrophage cell shape and phenotype","volume":"7","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"2023080908424339600_c258","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1021\/acsbiomaterials.7b00104","article-title":"Unbiased analysis of the impact of micropatterned biomaterials on macrophage behavior provides insights beyond predefined polarization states","volume":"3","year":"2017","journal-title":"ACS Biomater. Sci. Eng."},{"key":"2023080908424339600_c259","doi-asserted-by":"publisher","first-page":"1900","DOI":"10.1021\/bm200248h","article-title":"Effect of electrospun fiber diameter and alignment on macrophage activation and secretion of proinflammatory cytokines and chemokines","volume":"12","year":"2011","journal-title":"Biomacromolecules"},{"key":"2023080908424339600_c260","doi-asserted-by":"publisher","first-page":"4439","DOI":"10.1016\/j.biomaterials.2013.02.065","article-title":"Macrophage functional polarization (M1\/M2) in response to varying fiber and pore dimensions of electrospun scaffolds","volume":"34","year":"2013","journal-title":"Biomaterials"},{"key":"2023080908424339600_c261","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1080\/09205063.2017.1321345","article-title":"The effect of engineered nanotopography of electrospun microfibers on fiber rigidity and macrophage cytokine production","volume":"28","year":"2017","journal-title":"J. Biomater. Sci., Polym. Ed."},{"key":"2023080908424339600_c262","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.biocel.2014.09.006","article-title":"Reduced inflammatory activity of RAW 264.7 macrophages on titania nanotube modified Ti surface","volume":"55","year":"2014","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"2023080908424339600_c263","doi-asserted-by":"publisher","first-page":"110221","DOI":"10.1016\/j.msec.2019.110221","article-title":"The unique regulation of implant surface nanostructure on macrophages M1 polarization","volume":"106","year":"2020","journal-title":"Mater. Sci. Eng. C"},{"key":"2023080908424339600_c264","doi-asserted-by":"publisher","first-page":"3864","DOI":"10.1016\/j.actbio.2010.04.025","article-title":"Induction of specific macrophage subtypes by defined micro-patterned structures","volume":"6","year":"2010","journal-title":"Acta Biomater."},{"key":"2023080908424339600_c265","doi-asserted-by":"publisher","first-page":"1562","DOI":"10.1039\/C6BM00425C","article-title":"Convex and concave micro-structured silicone controls the shape, but not the polarization state of human macrophages","volume":"4","year":"2016","journal-title":"Biomater. Sci."},{"key":"2023080908424339600_c266","doi-asserted-by":"publisher","first-page":"10887","DOI":"10.1038\/s41598-018-29167-2","article-title":"A micron-scale surface topography design reducing cell adhesion to implanted materials","volume":"8","year":"2018","journal-title":"Sci. Rep."},{"key":"2023080908424339600_c267","doi-asserted-by":"publisher","first-page":"1903392","DOI":"10.1002\/advs.201903392","article-title":"Immune modulation by design: Using topography to control human monocyte attachment and macrophage differentiation","volume":"7","year":"2020","journal-title":"Adv. Sci."},{"key":"2023080908424339600_c268","doi-asserted-by":"publisher","first-page":"4594","DOI":"10.1021\/acs.nanolett.0c01448","article-title":"Micro-\/nanotopography on bioresorbable zinc dictates cytocompatibility, bone cell differentiation, and macrophage polarization","volume":"20","year":"2020","journal-title":"Nano Lett."},{"key":"2023080908424339600_c269","doi-asserted-by":"publisher","first-page":"3011","DOI":"10.1039\/C8LC00431E","article-title":"Surface topography and hydrophilicity regulate macrophage phenotype in milled microfluidic systems","volume":"18","year":"2018","journal-title":"Lab Chip"},{"key":"2023080908424339600_c270","doi-asserted-by":"publisher","first-page":"2092","DOI":"10.1016\/j.carbon.2011.01.044","article-title":"Control of macrophage responses on hydrophobic and hydrophilic carbon nanostructures","volume":"49","year":"2011","journal-title":"Carbon"},{"key":"2023080908424339600_c271","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.colsurfb.2018.03.029","article-title":"Macrophage polarization, inflammatory signaling, and NF-\u03baB activation in response to chemically modified titanium surfaces","volume":"166","year":"2018","journal-title":"Colloids Surf., B"},{"key":"2023080908424339600_c272","doi-asserted-by":"publisher","first-page":"1800675","DOI":"10.1002\/adhm.201800675","article-title":"Unveiling the mechanism of surface hydrophilicity-modulated macrophage polarization","volume":"7","year":"2018","journal-title":"Adv. Healthcare Mater."},{"key":"2023080908424339600_c273","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1002\/jbm.a.34104","article-title":"The effects of substrate stiffness on the in vitro activation of macrophages and in vivo host response to poly(ethylene glycol)-based hydrogels","volume":"100","year":"2012","journal-title":"J. Biomed. Mater. Res., Part A"},{"key":"2023080908424339600_c274","doi-asserted-by":"publisher","first-page":"e0145813","DOI":"10.1371\/journal.pone.0145813","article-title":"Substrate stiffness regulates proinflammatory mediator production through TLR4 activity in macrophages","volume":"10","year":"2015","journal-title":"PLoS One"},{"key":"2023080908424339600_c275","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1093\/intimm\/dxy027","article-title":"Toll-like receptor signaling in macrophages is regulated by extracellular substrate stiffness and Rho-associated coiled-coil kinase (ROCK1\/2)","volume":"30","year":"2018","journal-title":"Int. Immunol."},{"key":"2023080908424339600_c276","doi-asserted-by":"publisher","first-page":"9755","DOI":"10.1016\/j.biomaterials.2014.08.023","article-title":"Biocompatibility and inflammatory response in vitro and in vivo to gelatin-based biomaterials with tailorable elastic properties","volume":"35","year":"2014","journal-title":"Biomaterials"},{"key":"2023080908424339600_c277","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/j.msec.2019.03.107","article-title":"Modulating macrophage responses to promote tissue regeneration by changing the formulation of bone extracellular matrix from filler particles to gel bioscaffolds","volume":"101","year":"2019","journal-title":"Mater. Sci. Eng.: C"},{"key":"2023080908424339600_c278","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.pbiomolbio.2019.05.006","article-title":"PCL\/EUG scaffolds with tunable stiffness can regulate macrophage secretion behavior","volume":"148","year":"2018","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"2023080908424339600_c279","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.1016\/S0002-9440(10)65051-1","article-title":"Biomechanical regulation of human monocyte\/macrophage molecular function","volume":"156","year":"2000","journal-title":"Am. J. Pathol."},{"key":"2023080908424339600_c280","doi-asserted-by":"publisher","first-page":"4919","DOI":"10.1016\/j.biomaterials.2014.03.002","article-title":"Strain-dependent modulation of macrophage polarization within scaffolds","volume":"35","year":"2014","journal-title":"Biomaterials"},{"key":"2023080908424339600_c281","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1089\/ten.tea.2018.0306","article-title":"Cyclic strain affects macrophage cytokine secretion and extracellular matrix turnover in electrospun scaffolds","volume":"25","year":"2018","journal-title":"Tissue Eng., Part A"},{"key":"2023080908424339600_c282","doi-asserted-by":"publisher","first-page":"L1040","DOI":"10.1152\/ajplung.1998.275.6.L1040","article-title":"Activation of human macrophages by mechanical ventilation in vitro","volume":"275","year":"1998","journal-title":"Am. J. Physiol.-Lung Cell. Mol. Physiol."},{"key":"2023080908424339600_c283","doi-asserted-by":"publisher","first-page":"L699","DOI":"10.1152\/ajplung.2000.279.4.L699","article-title":"Mechanical stretch stimulates macrophage inflammatory protein-2 secretion from fetal rat lung cells","volume":"279","year":"2000","journal-title":"Am. J. Physiol.-Lung Cell. Mol. Physiol."},{"key":"2023080908424339600_c284","doi-asserted-by":"publisher","first-page":"3590","DOI":"10.4049\/jimmunol.1200860","article-title":"Activation of NLRP3 inflammasome in alveolar macrophages contributes to mechanical stretch-induced lung inflammation and injury","volume":"190","year":"2013","journal-title":"J. Immunol."},{"key":"2023080908424339600_c285","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.biomaterials.2005.05.070","article-title":"Characterization of the FlexcellTM UniflexTM cyclic strain culture system with U937 macrophage-like cells","volume":"27","year":"2006","journal-title":"Biomaterials"},{"key":"2023080908424339600_c286","doi-asserted-by":"publisher","first-page":"G1187","DOI":"10.1152\/ajpgi.00452.2009","article-title":"Mechanical strain and TLR4 synergistically induce cell-specific inflammatory gene expression in intestinal smooth muscle cells and peritoneal macrophages","volume":"299","year":"2010","journal-title":"Am. J. Physiol.-Gastrointest. Liver Physiol."},{"key":"2023080908424339600_c287","doi-asserted-by":"publisher","first-page":"C431","DOI":"10.1152\/ajpcell.00202.2012","article-title":"Aggravation of inflammatory response by costimulation with titanium particles and mechanical perturbations in osteoblast- and macrophage-like cells","volume":"304","year":"2013","journal-title":"Am. J. Physiol.-Cell Physiol."},{"key":"2023080908424339600_c288","doi-asserted-by":"publisher","first-page":"1850","DOI":"10.1038\/s41467-019-09709-6","article-title":"Dynamic fibroblast contractions attract remote macrophages in fibrillar collagen matrix","volume":"10","year":"2019","journal-title":"Nat. Commun."},{"key":"2023080908424339600_c289","doi-asserted-by":"publisher","first-page":"6415","DOI":"10.1021\/acs.nanolett.7b03405","article-title":"Remote manipulation of ligand nano-oscillations regulates adhesion and polarization of macrophages in vivo","volume":"17","year":"2017","journal-title":"Nano Lett."},{"key":"2023080908424339600_c290","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1302\/0301-620X.82B5.0820755","article-title":"The effect of cyclic pressure on human monocyte-derived macrophages in vitro","volume":"82","year":"2000","journal-title":"J. Bone Jt. Surg. Br."},{"key":"2023080908424339600_c291","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/j.atherosclerosis.2007.08.027","article-title":"The role of hydrostatic pressure in foam cell formation upon exposure of macrophages to LDL and oxidized LDL","volume":"197","year":"2008","journal-title":"Atherosclerosis"},{"key":"2023080908424339600_c292","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/j.amjsurg.2005.07.016","article-title":"Differential regulation of monocyte\/macrophage cytokine production by pressure","volume":"190","year":"2005","journal-title":"Am. J. Surg."},{"key":"2023080908424339600_c293","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/1465-9921-10-44","article-title":"Cyclic hydrostatic pressure and cotton particles stimulate synthesis by human lung macrophages of cytokines in vitro","volume":"10","year":"2009","journal-title":"Respir. Res."},{"key":"2023080908424339600_c294","doi-asserted-by":"publisher","first-page":"1927","DOI":"10.1091\/mbc.E18-03-0164","article-title":"Interstitial flow promotes macrophage polarization toward an M2 phenotype","volume":"29","year":"2018","journal-title":"Mol. Biol. Cell"},{"key":"2023080908424339600_c295","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1093\/intbio\/zyaa007","article-title":"Integrated in silico and 3D in vitro model of macrophage migration in response to physical and chemical factors in the tumor microenvironment","volume":"12","year":"2020","journal-title":"Integr. Biol."},{"key":"2023080908424339600_c296","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.ijsu.2015.07.719","article-title":"Effect of shock waves on macrophages: A possible role in tissue regeneration and remodeling","volume":"24","year":"2015","journal-title":"Int. J. Surg."},{"key":"2023080908424339600_c297","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1189\/jlb.3A0815-390R","article-title":"Electric fields are novel determinants of human macrophage functions","volume":"99","year":"2016","journal-title":"J. Leukocyte Biol."},{"key":"2023080908424339600_c298","doi-asserted-by":"publisher","first-page":"2001","DOI":"10.1016\/j.bpj.2018.03.002","article-title":"Magnetic field changes macrophage phenotype","volume":"114","year":"2018","journal-title":"Biophys. J."},{"key":"2023080908424339600_c299","doi-asserted-by":"publisher","first-page":"1801451","DOI":"10.1002\/adhm.201801451","article-title":"Macrophage and fibroblast interactions in biomaterial-mediated fibrosis","volume":"8","year":"2019","journal-title":"Adv. Healthcare Mater."},{"key":"2023080908424339600_c300","doi-asserted-by":"publisher","first-page":"2731","DOI":"10.4049\/jimmunol.172.5.2731","article-title":"Of mice and not men: Differences between mouse and human immunology","volume":"172","year":"2004","journal-title":"J. Immunol."},{"key":"2023080908424339600_c301","doi-asserted-by":"publisher","first-page":"jcs241075","DOI":"10.1242\/jcs.241075","article-title":"The power from within\u2013understanding the driving forces of neutrophil extracellular trap formation","volume":"133","year":"2020","journal-title":"J. Cell Sci."},{"key":"2023080908424339600_c302","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1084\/jem.20051123","article-title":"Macrophage fusion: The making of osteoclasts and giant cells","volume":"202","year":"2005","journal-title":"J. Exp. Med."},{"key":"2023080908424339600_c303","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1038\/s41578-019-0106-3","article-title":"Macroscale biomaterials strategies for local immunomodulation","volume":"4","year":"2019","journal-title":"Nat. Rev. Mater."}],"container-title":["APL Bioengineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.aip.org\/aip\/apb\/article-pdf\/doi\/10.1063\/5.0098578\/16440816\/031504_1_online.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pubs.aip.org\/aip\/apb\/article-pdf\/doi\/10.1063\/5.0098578\/16440816\/031504_1_online.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.aip.org\/aip\/apb\/article-pdf\/doi\/10.1063\/5.0098578\/16440816\/031504_1_online.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T20:07:27Z","timestamp":1745352447000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.aip.org\/apb\/article\/6\/3\/031504\/2820346\/Engineering-physical-microenvironments-to-study"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,1]]},"references-count":303,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,9,1]]}},"URL":"https:\/\/doi.org\/10.1063\/5.0098578","relation":{},"ISSN":["2473-2877"],"issn-type":[{"value":"2473-2877","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,9]]},"published":{"date-parts":[[2022,9,1]]},"article-number":"031504"}}