{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T23:10:38Z","timestamp":1783033838911,"version":"3.54.6"},"reference-count":57,"publisher":"AIP Publishing","issue":"12","funder":[{"DOI":"10.13039\/100007388","name":"Compagnia di San Paolo","doi-asserted-by":"publisher","award":["CSTO 160444"],"award-info":[{"award-number":["CSTO 160444"]}],"id":[{"id":"10.13039\/100007388","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pubs.aip.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,12,1]]},"abstract":"<jats:p>Atrial fibrillation (AF) is the most common cardiac arrhythmia, inducing irregular and faster heart beating. Aside from disabling symptoms\u2014such as palpitations, chest discomfort, and reduced exercise capacity\u2014there is growing evidence that AF increases the risk of dementia and cognitive decline, even in the absence of clinical strokes. Among the possible mechanisms, the alteration of deep cerebral hemodynamics during AF is one of the most fascinating and least investigated hypotheses. Lenticulostriate arteries (LSAs)\u2014small perforating arteries perpendicularly departing from the anterior and middle cerebral arteries and supplying blood flow to basal ganglia\u2014are especially involved in silent strokes and cerebral small vessel diseases, which are considered among the main vascular drivers of dementia. We propose for the first time a computational fluid dynamics analysis to investigate the AF effects on the LSAs hemodynamics by using 7\u2009T high-resolution magnetic resonance imaging (MRI). We explored different heart rates (HRs)\u2014from 50 to 130 bpm\u2014in sinus rhythm and AF, exploiting MRI data from a healthy young male and internal carotid artery data from validated 0D cardiovascular-cerebral modeling as inflow condition. Our results reveal that AF induces a marked reduction of wall shear stress and flow velocity fields. This study suggests that AF at higher HR leads to a more hazardous hemodynamic scenario by increasing the atheromatosis and thrombogenesis risks in the LSAs region.<\/jats:p>","DOI":"10.1063\/5.0129899","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T03:37:45Z","timestamp":1669865865000},"update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":13,"title":["Cerebral hemodynamics during atrial fibrillation: Computational fluid dynamics analysis of lenticulostriate arteries using 7\u2009T high-resolution magnetic resonance imaging"],"prefix":"10.1063","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9427-6491","authenticated-orcid":false,"given":"S.","family":"Scarsoglio","sequence":"first","affiliation":[{"name":"Department of Mechanical and Aerospace Engineering, Politecnico di Torino 1 , Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9475-1507","authenticated-orcid":false,"given":"A.","family":"Saglietto","sequence":"additional","affiliation":[{"name":"Division of Cardiology, \u201cCitt\u00e0 della Salute e della Scienza di Torino\u201d Hospital, Universit\u00e0 di Torino 2 , Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5926-9464","authenticated-orcid":false,"given":"F.","family":"Tripoli","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Aerospace Engineering, Politecnico di Torino 1 , Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4282-5719","authenticated-orcid":false,"given":"J. 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