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These calculations often involve a significant amount of manual input and expertise, although most of this effort could be automated, which would alleviate the need for expertise in software and hardware accessibility. Here, we present the AutoRXN workflow, an automated workflow for exploratory high-throughput electronic structure calculations of molecular systems, in which (i) density functional theory methods are exploited to deliver minimum and transition-state structures and corresponding energies and properties, (ii) coupled cluster calculations are then launched for optimized structures to provide more accurate energy and property estimates, and (iii) multi-reference diagnostics are evaluated to back check the coupled cluster results and subject them to automated multi-configurational calculations for potential multi-configurational cases. All calculations are carried out in a cloud environment and support massive computational campaigns. Key features of all components of the AutoRXN workflow are autonomy, stability, and minimum operator interference. We highlight the AutoRXN workflow with the example of an autonomous reaction mechanism exploration of the mode of action of a homogeneous catalyst for the asymmetric reduction of ketones.<\/jats:p>","DOI":"10.1063\/5.0136526","type":"journal-article","created":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T02:34:22Z","timestamp":1675737262000},"update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":23,"title":["High-throughput <i>ab initio<\/i> reaction mechanism exploration in the cloud with automated multi-reference validation"],"prefix":"10.1063","volume":"158","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3465-5788","authenticated-orcid":false,"given":"Jan P.","family":"Unsleber","sequence":"first","affiliation":[{"name":"Laboratory of Physical Chemistry and NCCR Catalysis, ETH Zurich 1 , Vladimir-Prelog-Weg 2, 8093 Zurich, 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