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Moreover, the new predominant strain, Omicron variant, manifests more similar clinical features to those of other common respiratory infections. The concurrent detection of multiple potential pathogens helps distinguish SARS-CoV-2 infection from other diseases with overlapping symptoms, which is significant for providing tailored treatment to patients and containing the outbreak. Here, we report a lab-on-a-chip biosensing platform for SARS-CoV-2 detection based on the subwavelength grating micro-ring resonator. The sensing surface is functionalized by specific antibody against SARS-CoV-2 spike protein, which could produce redshifts of resonant peaks by antigen\u2013antibody combination, thus achieving quantitative detection. Additionally, the sensor chip is integrated with a microfluidic chip featuring an anti-backflow Y-shaped structure that enables the concurrent detection of two analytes. In this study, we realized the detection and differentiation of COVID-19 and influenza A H1N1. Experimental results indicate that the limit of detection of our device reaches 100 fg\/ml (1.31 fM) within 15\u2009min detecting time, and cross-reactivity tests manifest the specificity of the optical diagnostic assay. Furthermore, the integrated packaging and streamlined workflow facilitate its use for clinical applications. Thus, the biosensing platform presents a promising approach for attaining highly sensitive, selective, multiplexed, and quantitative point-of-care diagnosis and distinction between COVID-19 and influenza.<\/jats:p>","DOI":"10.1063\/5.0146079","type":"journal-article","created":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T09:27:40Z","timestamp":1685006860000},"update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":41,"title":["A point-of-care biosensor for rapid detection and differentiation of COVID-19 virus (SARS-CoV-2) and influenza virus using subwavelength grating micro-ring resonator"],"prefix":"10.1063","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5780-9711","authenticated-orcid":false,"given":"Shupeng","family":"Ning","sequence":"first","affiliation":[{"name":"Department of Electrical and Computer Engineering, The University of Texas at Austin 1 , Austin, Texas 78758, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao-Chen","family":"Chang","sequence":"additional","affiliation":[{"name":"Omega Optics, Inc. 2 , 8500 Shoal Creek Blvd., Austin, Texas 78757, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang-Chieh","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, The University of Texas at Austin 1 , Austin, Texas 78758, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6172-1454","authenticated-orcid":false,"given":"Po-Yu","family":"Hsiao","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, The University of Texas at Austin 1 , Austin, Texas 78758, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0751-7681","authenticated-orcid":false,"given":"Chenghao","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, The University of Texas at Austin 1 , Austin, Texas 78758, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0917-103X","authenticated-orcid":false,"given":"Devan","family":"Shoemaker","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, The University of Texas at Austin 1 , Austin, Texas 78758, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9181-4266","authenticated-orcid":false,"given":"Ray T.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, The University of Texas at Austin 1 , Austin, Texas 78758, USA"},{"name":"Omega Optics, Inc. 2 , 8500 Shoal Creek Blvd., Austin, Texas 78757, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"317","published-online":{"date-parts":[[2023,5,25]]},"reference":[{"key":"2024052500011792000_c1","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.ijid.2020.01.050","article-title":"Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020: A data-driven analysis in the early phase of the outbreak","volume":"92","year":"2020","journal-title":"Int. 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