{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:16:15Z","timestamp":1788448575804,"version":"build-2803163510"},"reference-count":62,"publisher":"AIP Publishing","issue":"11","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["12072265"],"award-info":[{"award-number":["12072265"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11972292"],"award-info":[{"award-number":["11972292"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Innovation Foundation for Doctor Dissertation of Northwestern Polytechnical University","award":["CX2023089"],"award-info":[{"award-number":["CX2023089"]}]}],"content-domain":{"domain":["pubs.aip.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"<jats:p>This paper aims to establish a coupling model of neuronal populations and astrocytes and, on this basis, explore the possible mechanism of electroencephalography (EEG) slowing in Alzheimer\u2019s disease (AD) from the viewpoint of dynamical modeling. First and foremost, excitatory and inhibitory time constants are shown to induce the early symptoms of AD. The corresponding dynamic nature is mainly due to changes in the amplitude and frequency of the oscillatory behavior. However, there are also a few cases that can be attributed to the change of the oscillation mode caused by the limit cycle bifurcation and birhythmicity. Then, an improved neural mass model influenced by astrocytes is proposed, considering the important effects of glutamate and adenosine triphosphate (ATP) released by astrocytes on the synaptic transmission process reported in experiments. The results show that a dysfunctional astrocyte disrupts the physiological state, causing three typical EEG slowing phenomena reported clinically: the decreased dominant frequency, the decreased rhythmic activity in the \u03b1 band, and the increased rhythmic activity in the \u03b4+\u03b8 band. In addition, astrocytes may control AD when the effect of ATP on synaptic connections is greater than that of glutamate. The control rate depends on the ratio of the effect of glutamate on excitatory and inhibitory synaptic connections. These modeling results can not only reproduce some experimental and clinical results, but, more importantly, may offer a prediction of some underlying phenomena, helping to inspire the disease mechanisms and therapeutic methods of targeting astrocytes.<\/jats:p>","DOI":"10.1063\/5.0154322","type":"journal-article","created":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T13:04:45Z","timestamp":1699016685000},"update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":6,"title":["The important role of glial transmitters released by astrocytes in Alzheimer\u2019s disease: A perspective from dynamical modeling"],"prefix":"10.1063","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1157-1079","authenticated-orcid":false,"given":"Zhuan","family":"Shen","sequence":"first","affiliation":[{"name":"MIIT Key Laboratory of Dynamics and Control of Complex Systems 1 , Xi\u2019an, Shaanxi 710072, China"},{"name":"School of Mathematics and Statistics, Northwestern Polytechnical University 2 , Xi\u2019an, Shaanxi 710072, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8765-0457","authenticated-orcid":false,"given":"Honghui","family":"Zhang","sequence":"additional","affiliation":[{"name":"MIIT Key Laboratory of Dynamics and Control of Complex Systems 1 , Xi\u2019an, Shaanxi 710072, China"},{"name":"School of Mathematics and Statistics, Northwestern Polytechnical University 2 , Xi\u2019an, Shaanxi 710072, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2749-5416","authenticated-orcid":false,"given":"Lin","family":"Du","sequence":"additional","affiliation":[{"name":"MIIT Key Laboratory of Dynamics and Control of Complex Systems 1 , Xi\u2019an, Shaanxi 710072, China"},{"name":"School of Mathematics and Statistics, Northwestern Polytechnical University 2 , Xi\u2019an, Shaanxi 710072, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3275-1658","authenticated-orcid":false,"given":"Xiaoyan","family":"He","sequence":"additional","affiliation":[{"name":"School of Statistics and Mathematics, Inner Mongolia University of Finance and Economics 3 , Hohhot 010070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3705-4083","authenticated-orcid":false,"given":"Xiaojuan","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Science, Beijing University of Posts and Telecommunications 4 , Beijing 100876, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"317","published-online":{"date-parts":[[2023,11,3]]},"reference":[{"key":"2023110313040625000_c1","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.neuro.2017.03.006","article-title":"Risk factors associated with the onset and progression of Alzheimer\u2019s disease: A systematic review of the evidence","volume":"61","year":"2017","journal-title":"Neurotoxicology"},{"key":"2023110313040625000_c2","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The amyloid hypothesis of Alzheimer\u2019s disease: Progress and problems on the road to therapeutics","volume":"297","year":"2002","journal-title":"Science"},{"key":"2023110313040625000_c3","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.pharep.2014.09.004","article-title":"A review on Alzheimer\u2019s disease pathophysiology and its management: An update","volume":"67","year":"2015","journal-title":"Pharmacol. 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