{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T06:17:02Z","timestamp":1782886622933,"version":"3.54.5"},"reference-count":39,"publisher":"AIP Publishing","issue":"15","license":[{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["pubs.aip.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,10,21]]},"abstract":"<jats:p>We investigate the potential of surface plasmon polaritons at noble metal interfaces for surface-enhanced chiroptical sensing of dilute chiral drug solutions with nl volume. The high quality factor of surface plasmon resonances in both Otto and Kretschmann configurations enables the enhancement of circular dichroism differenatial absorption thanks to the large near-field intensity of such plasmonic excitations. Furthermore, the subwavelength confinement of surface plasmon polaritons is key to attain chiroptical sensitivity to small amounts of drug volumes placed around \u2243100 nm by the metal surface. Our calculations focus on reparixin, a pharmaceutical molecule currently used in clinical studies for patients with community-acquired pneumonia, including COVID-19 and acute respiratory distress syndrome. Considering realistic dilute solutions of reparixin dissolved in water with concentration \u22645 mg\/ml and nl volume, we find a circular-dichroism differential absorption enhancement factor of the order \u224320 and chirality-induced polarization distortion upon surface plasmon polariton excitation. Our results are relevant for the development of innovative chiroptical sensors capable of measuring the enantiomeric imbalance of chiral drug solutions with nl volume.<\/jats:p>","DOI":"10.1063\/5.0169826","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T11:54:36Z","timestamp":1697543676000},"update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":12,"title":["Plasmon-enhanced circular dichroism spectroscopy of chiral drug solutions"],"prefix":"10.1063","volume":"159","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0654-8989","authenticated-orcid":false,"given":"Matteo","family":"Venturi","sequence":"first","affiliation":[{"name":"Department of Physical and Chemical Sciences, University of L\u2019Aquila 1 , Via Vetoio, 67100 L\u2019Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raju","family":"Adhikary","sequence":"additional","affiliation":[{"name":"Department of Physical and Chemical Sciences, University of L\u2019Aquila 1 , Via Vetoio, 67100 L\u2019Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambaresh","family":"Sahoo","sequence":"additional","affiliation":[{"name":"Department of Physical and Chemical Sciences, University of L\u2019Aquila 1 , Via Vetoio, 67100 L\u2019Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6391-0672","authenticated-orcid":false,"given":"Carino","family":"Ferrante","sequence":"additional","affiliation":[{"name":"CNR-SPIN, c\/o Dip.to di Scienze Fisiche e Chimiche 2 , Via Vetoio, Coppito (L\u2019Aquila) 67100, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8970-8408","authenticated-orcid":false,"given":"Isabella","family":"Daidone","sequence":"additional","affiliation":[{"name":"Department of Physical and Chemical Sciences, University of L\u2019Aquila 1 , Via Vetoio, 67100 L\u2019Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2079-3322","authenticated-orcid":false,"given":"Francesco","family":"Di Stasio","sequence":"additional","affiliation":[{"name":"Istituto Italiano di Tecnologia 3 , Via Morego 30, Genova 16136, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2877-9805","authenticated-orcid":false,"given":"Andrea","family":"Toma","sequence":"additional","affiliation":[{"name":"Istituto Italiano di Tecnologia 3 , Via Morego 30, Genova 16136, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6482-0647","authenticated-orcid":false,"given":"Francesco","family":"Tani","sequence":"additional","affiliation":[{"name":"Max Planck Institute for the Science of Light 4 , Staudtstr. 2, 91058 Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatice","family":"Altug","sequence":"additional","affiliation":[{"name":"Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne (EPFL) 5 , Lausanne 1015, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8730-5699","authenticated-orcid":false,"given":"Antonio","family":"Mecozzi","sequence":"additional","affiliation":[{"name":"Department of Physical and Chemical Sciences, University of L\u2019Aquila 1 , Via Vetoio, 67100 L\u2019Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2959-0158","authenticated-orcid":false,"given":"Massimiliano","family":"Aschi","sequence":"additional","affiliation":[{"name":"Department of Physical and Chemical Sciences, University of L\u2019Aquila 1 , Via Vetoio, 67100 L\u2019Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2763-6394","authenticated-orcid":false,"given":"Andrea","family":"Marini","sequence":"additional","affiliation":[{"name":"Department of Physical and Chemical Sciences, University of L\u2019Aquila 1 , Via Vetoio, 67100 L\u2019Aquila, Italy"},{"name":"CNR-SPIN, c\/o Dip.to di Scienze Fisiche e Chimiche 2 , Via Vetoio, Coppito (L\u2019Aquila) 67100, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"317","published-online":{"date-parts":[[2023,10,17]]},"reference":[{"key":"2023120718484504400_c1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.59566\/IJBS.2006.2085","article-title":"Chiral drugs: An overview","volume":"2","year":"2006","journal-title":"Int. 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