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M. Keck Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000888","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006221","name":"United States - Israel Binational Science Foundation","doi-asserted-by":"publisher","award":["2022503"],"award-info":[{"award-number":["2022503"]}],"id":[{"id":"10.13039\/100006221","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pubs.aip.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,12,14]]},"abstract":"<jats:p>We analyze from a theoretical perspective recent experiments where chiral discrimination in biological systems was established using Atomic Force Microscopy (AFM). Even though intermolecular forces involved in AFM measurements have different origins, i.e., electrostatic, bonding, exchange, and multipole interactions, the key molecular forces involved in enantiospecific biorecognition are electronic spin exchange and van der Waals (vdW) dispersion forces, which are sensitive to spin\u2013orbit interaction (SOI) and space-inversion symmetry breaking in chiral molecules. The vdW contribution to chiral discrimination emerges from the inclusion of SOI and spin fluctuations due to the chiral-induced selectivity effect, a result we have recently demonstrated theoretically. Considering these two enantiospecific contributions, we show that the AFM results regarding chiral recognition can be understood in terms of a simple physical model that describes the different adhesion forces associated with different electron spin polarization generated in the (DD), (LL), and (DL) enantiomeric pairs, as arising from the spin part of the exchange and vdW contributions. The model can successfully produce physically reasonable parameters accounting for the vdW and exchange interaction strength, accounting for the chiral discrimination effect. This fact has profound implications in biorecognition where the relevant intermolecular interactions in the intermediate-distance regime are clearly connected to vdW forces.<\/jats:p>","DOI":"10.1063\/5.0171742","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T11:18:42Z","timestamp":1702034322000},"update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":14,"title":["Probing chiral discrimination in biological systems using atomic force microscopy: The role of van der Waals and exchange interactions"],"prefix":"10.1063","volume":"159","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5019-2117","authenticated-orcid":false,"given":"Yael","family":"Kapon","sequence":"first","affiliation":[{"name":"Institute of Applied Physics, Faculty of Science, The Hebrew University of Jerusalem 1 , Jerusalem 9190401, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5937-5323","authenticated-orcid":false,"given":"Qirong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Physics, Weizmann Institute of Science 2 , Rehovot 76100, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9180-4669","authenticated-orcid":false,"given":"Shira","family":"Yochelis","sequence":"additional","affiliation":[{"name":"Institute of Applied Physics, Faculty of Science, The Hebrew University of Jerusalem 1 , Jerusalem 9190401, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1910-366X","authenticated-orcid":false,"given":"Ron","family":"Naaman","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Physics, Weizmann Institute of Science 2 , Rehovot 76100, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8121-8041","authenticated-orcid":false,"given":"Rafael","family":"Gutierrez","sequence":"additional","affiliation":[{"name":"Institute for Materials Science and Max\u00a0Bergmann Center of Biomaterials, Dresden University of Technology 3 , 01062 Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6574-7848","authenticated-orcid":false,"given":"Giannaurelio","family":"Cuniberti","sequence":"additional","affiliation":[{"name":"Institute for Materials Science and Max\u00a0Bergmann Center of Biomaterials, Dresden University of Technology 3 , 01062 Dresden, Germany"},{"name":"Dresden Center for Computational Materials Science 4 , 01062 Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8739-9952","authenticated-orcid":false,"given":"Yossi","family":"Paltiel","sequence":"additional","affiliation":[{"name":"Institute of Applied Physics, Faculty of Science, The Hebrew University of Jerusalem 1 , Jerusalem 9190401, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5237-4851","authenticated-orcid":false,"given":"Vladimiro","family":"Mujica","sequence":"additional","affiliation":[{"name":"Arizona State University, School of Molecular Sciences 5 , P.O. 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