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Meanwhile, many preclinical data have demonstrated that gene and cell therapies combined with optimal scaffold biomaterials could be used to solve these tough issues. Bone tissue engineering, an interdisciplinary field combining cells, biomaterials, and molecules with stimulatory capability, provides promising alternatives to enhance bone regeneration. To deliver and localize growth factors and associated intracellular signaling components into the defect site, gene therapy strategies combined with bioengineering could achieve a uniform distribution and sustained release to ensure mesenchymal stem cell osteogenesis. In this review, we will describe the process and cell molecular changes during normal fracture healing, followed by the advantages and disadvantages of various gene therapy vectors combined with bone tissue engineering. The growth factors and other bioactive peptides in bone regeneration will be particularly discussed. Finally, gene-activated biomaterials for bone regeneration will be illustrated through a description of characteristics and synthetic methods.<\/jats:p>","DOI":"10.1063\/5.0200551","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T08:45:55Z","timestamp":1726649155000},"update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":12,"title":["Research progress of gene therapy combined with tissue engineering to promote bone regeneration"],"prefix":"10.1063","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3320-9359","authenticated-orcid":false,"given":"Xiangyu","family":"Chu","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology 1 , 1277 Jiefang Avenue, Wuhan 430022, China"},{"name":"Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration 2 , Wuhan 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