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In this work, we present a new approach rooted in classical density functional theory (cDFT) that allows us to accurately describe the solvation of apolar solutes across length scales. Our approach builds on the Lum\u2013Chandler\u2013Weeks (LCW) theory of hydrophobicity [K. Lum et al., J. Phys. Chem. B 103, 4570 (1999)] by constructing a free energy functional that uses a slowly varying component of the density field as a reference. From a practical viewpoint, the theory we present is numerically simpler and generalizes to solutes with soft-core repulsion more easily than LCW theory. Furthermore, by assessing the local compressibility and its critical scaling behavior, we demonstrate that our LCW-style cDFT approach contains the physics of critical drying, which has been emphasized as an essential aspect of hydrophobicity by recent theories. As our approach is parameterized on the two-body direct correlation function of the uniform fluid and the liquid\u2013vapor surface tension, it straightforwardly captures the temperature dependence of solvation. Moreover, we use our theory to describe solvation at a first-principles level on length scales that vastly exceed what is accessible to molecular simulations.<\/jats:p>","DOI":"10.1063\/5.0223750","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T10:16:15Z","timestamp":1725876975000},"update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":18,"title":["A classical density functional theory for solvation across length scales"],"prefix":"10.1063","volume":"161","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0981-4329","authenticated-orcid":false,"given":"Anna T.","family":"Bui","sequence":"first","affiliation":[{"name":"Yusuf Hamied Department of Chemistry, University of Cambridge , Lensfield Road, Cambridge CB2 1EW, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2708-8711","authenticated-orcid":false,"given":"Stephen J.","family":"Cox","sequence":"additional","affiliation":[{"name":"Yusuf Hamied Department of Chemistry, University of Cambridge , Lensfield Road, Cambridge CB2 1EW, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"317","published-online":{"date-parts":[[2024,9,9]]},"reference":[{"key":"2024090910065426300_c1","doi-asserted-by":"publisher","first-page":"8069","DOI":"10.1073\/pnas.83.21.8069","article-title":"Temperature dependence of the hydrophobic interaction in protein folding","volume":"83","year":"1986","journal-title":"Proc. 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