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The current widely used treatment is the implantable cardioverter defibrillator (ICD), but it is invasive and affects the patient\u2019s quality of life. The sonogenetic mechanism proposed here focuses ultrasound on a cardiac tissue, controls endogenous stretch-activated Piezo1 ion channels on the focal region\u2019s cardiomyocyte sarcolemma, and restores normal heart rhythm. In contrast to anchoring the implanted ICD lead at a fixed position in the myocardium, the size and position of the ultrasound focal region can be selected dynamically by adjusting the signals of every piezoelectric chip on the ultrasonic phased array, and it allows novel and efficient defibrillations. Based on the developed interdisciplinary electro-mechanical model of sonogenetic treatment, our analysis shows that the proposed ultrasound intensity and frequency will be safe and painless for humans and well below the limits established by the U.S. Food and Drug Administration.<\/jats:p>","DOI":"10.1063\/5.0224817","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T18:09:24Z","timestamp":1736532564000},"update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":2,"title":["Sonogenetics is a novel antiarrhythmic mechanism"],"prefix":"10.1063","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7002-8383","authenticated-orcid":false,"given":"Yang","family":"Li","sequence":"first","affiliation":[{"name":"School of Science, Beijing University of Posts and Telecommunications 1 , Beijing 100876,","place":["China"]},{"name":"School of Physics and Information Technology, Shaanxi Normal University 2 , Xi\u2019an 710062,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6851-0109","authenticated-orcid":false,"given":"Xingang","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Physics and Information Technology, Shaanxi Normal University 2 , Xi\u2019an 710062,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1909-3510","authenticated-orcid":false,"given":"Jianzhong","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Physics and Information Technology, Shaanxi Normal University 2 , Xi\u2019an 710062,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8518-6745","authenticated-orcid":false,"given":"Yong","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory for Fluid Physics, Pattern Formation and Biocomplexity, Max Planck Institute for Dynamics and Self-Organization 3 , G\u00f6ttingen 37077,","place":["Germany"]},{"name":"DZHK (German Center for Cardiovascular Research) 4 , Partner Site G\u00f6ttingen, G\u00f6ttingen 37077,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2093-7883","authenticated-orcid":false,"given":"Vladimir","family":"Zykov","sequence":"additional","affiliation":[{"name":"Laboratory for Fluid Physics, Pattern Formation and Biocomplexity, Max Planck Institute for Dynamics and Self-Organization 3 , G\u00f6ttingen 37077,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2901-0144","authenticated-orcid":false,"given":"Eberhard","family":"Bodenschatz","sequence":"additional","affiliation":[{"name":"Laboratory for Fluid Physics, Pattern Formation and Biocomplexity, Max Planck Institute for Dynamics and Self-Organization 3 , G\u00f6ttingen 37077,","place":["Germany"]},{"name":"DZHK (German Center for Cardiovascular Research) 4 , Partner Site G\u00f6ttingen, G\u00f6ttingen 37077,","place":["Germany"]},{"name":"Institute for Dynamics of Complex Systems, University of G\u00f6ttingen 5 , G\u00f6ttingen 37075,","place":["Germany"]},{"name":"Laboratory of Atomic and Solid-State Physics and Sibley School of Mechanical and Aerospace Engineering, Cornell University 6 , Ithaca, New York 14853,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9073-6243","authenticated-orcid":false,"given":"Xiang","family":"Gao","sequence":"additional","affiliation":[{"name":"School of Physics and Information Technology, Shaanxi Normal University 2 , Xi\u2019an 710062,","place":["China"]},{"name":"Laboratory for Fluid Physics, Pattern Formation and Biocomplexity, Max Planck Institute for Dynamics and Self-Organization 3 , G\u00f6ttingen 37077,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"317","published-online":{"date-parts":[[2025,1,10]]},"reference":[{"key":"2025011018083727600_c1","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1038\/32170","article-title":"Spatiotemporal evolution of ventricular fibrillation","volume":"392","year":"1998","journal-title":"Nature"},{"key":"2025011018083727600_c2","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/32044","article-title":"A last wave from the dying heart","volume":"392","year":"1998","journal-title":"Nature"},{"key":"2025011018083727600_c3","doi-asserted-by":"publisher","first-page":"6061","DOI":"10.1073\/pnas.090492697","article-title":"Preventing ventricular fibrillation by flattening cardiac restitution","volume":"97","year":"2000","journal-title":"Proc. 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