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Characterizing the molecular features in heterogeneous membranes is extremely challenging due to the experimentally inaccessible time- and length-scales of these emergent systems. In this context, simulations can provide important insights into molecular-level interactions leading to membrane heterogeneity and associated functions. To that end, we use the non-affine displacement (NAD) framework (a concept borrowed from the physics of granular materials) to faithfully capture molecular-scale local membrane order in simulated heterogeneous bilayers. In our latest application of NAD, we investigate the temperature-dependent spatial and temporal organization on microsecond trajectories of liquid-ordered bilayer systems at all-atom resolution (DPPC\/DOPC\/CHOL: 0.55:0.15:0.30; 40 \u00d7 40\u00a0nm2 with a total of 5600 lipids and 2 \u00d7 106 atoms). Lateral organization in these large bilayer patches shows noticeable dynamic heterogeneity despite their liquid-ordered nature. Moreover, our NAD analyses reveal soft fluid channels within the tightly packed membrane reminiscent of the classical two-component Kob\u2013Andersen glass-forming binary mixture. Hence, we characterized these systems using classical glass physics markers for dynamic heterogeneities such as overlap, four-point susceptibility, Van Hove, and intermediate scattering functions to quantify the multiple time scales underlying the lipid dynamics. Our analyses reveal that highly ordered membrane systems can have glass-like dynamics with distinct soft fluid channels inside them. Biologically, these dynamic channels could act as conduits for facilitating molecular encounters for biological functions even in highly ordered phases such as lipid nanodomains and rafts.<\/jats:p>","DOI":"10.1063\/5.0250190","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T06:22:16Z","timestamp":1744093336000},"update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":3,"title":["Signatures of glassy dynamics in highly ordered lipid bilayers with emergence of soft dynamic channels"],"prefix":"10.1063","volume":"162","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0670-6835","authenticated-orcid":false,"given":"Harini","family":"SureshKumar","sequence":"first","affiliation":[{"name":"Molecular Biophysics Unit, Indian Institute of Science 1 , Bangalore, KA 560012,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5591-5177","authenticated-orcid":false,"given":"Sahithya S.","family":"Iyer","sequence":"additional","affiliation":[{"name":"Department of Chemistry, The University of Chicago 2 , Chicago, Illinois 60637,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0518-609X","authenticated-orcid":false,"given":"Atreyee","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Polymer Research 3 , Ackermannweg 10, 55128 Mainz,","place":["Germany"]},{"name":"FRIAS, University of Freiburg 4 , Albertstra\u00dfe 19, 79104 Freiburg,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8031-0167","authenticated-orcid":false,"given":"Prathyush","family":"Poduval","sequence":"additional","affiliation":[{"name":"Department of Physics, Indian Institute of Science 5 , Bangalore, Karnataka 560012,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4590-0363","authenticated-orcid":false,"given":"Edward","family":"Lyman","sequence":"additional","affiliation":[{"name":"Department of Physics and Astronomy, and Department of Chemistry and Biochemistry, University of Delaware 6 , Newark, Delaware 19716,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2757-1511","authenticated-orcid":false,"given":"Anand","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Molecular Biophysics Unit, Indian Institute of Science 1 , Bangalore, KA 560012,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"317","published-online":{"date-parts":[[2025,4,8]]},"reference":[{"issue":"45","key":"2025040806051108300_c1","doi-asserted-by":"publisher","first-page":"17367","DOI":"10.1073\/pnas.0807527105","article-title":"The molecular face of lipid rafts in model membranes","volume":"105","year":"2008","journal-title":"Proc. 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