{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:20:08Z","timestamp":1772137208468,"version":"3.50.1"},"reference-count":127,"publisher":"AIP Publishing","issue":"21","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P20 GM135007"],"award-info":[{"award-number":["P20 GM135007"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DMR-1919610"],"award-info":[{"award-number":["DMR-1919610"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010941","name":"University of Vermont","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010941","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pubs.aip.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,6,7]]},"abstract":"<jats:p>We report on how low-frequency Raman measurements can be used as a facile tool to investigate the supramolecular structure of amyloid fibrils. We investigate the low-frequency Raman spectra (&amp;lt;500\u00a0cm\u22121) of six different amyloid fibrils exhibiting parallel \u03b2-sheet structures prepared from amyloid-\u03b21\u201340, amylin, amyloid-\u03b225\u201335, and amylin20\u201329 peptides. We propose band assignments using a combination of semi-empirical tight-binding calculations and insights gleaned from previously published studies on model polypeptides in \u03b2-sheet conformations. We discuss how low-frequency Raman modes can be used to probe the interactions, packing, and ordering of strands and side chains within fibril \u03b2-sheets to gain insights into their supramolecular structures.<\/jats:p>","DOI":"10.1063\/5.0260500","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T08:24:04Z","timestamp":1748939044000},"update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":3,"title":["Low-frequency Raman spectra of amyloid fibrils"],"prefix":"10.1063","volume":"162","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9894-1875","authenticated-orcid":false,"given":"Madeline","family":"Harper","sequence":"first","affiliation":[{"name":"Department of Chemistry, University of Vermont 1 , Burlington, Vermont 05405,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2693-8537","authenticated-orcid":false,"given":"Amanda","family":"Dumi","sequence":"additional","affiliation":[{"name":"Sandia National Laboratories 2 , Albuquerque, New Mexico 87185,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8501-0501","authenticated-orcid":false,"given":"Shiv","family":"Upadhyay","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Washington 3 , Seattle, Washington 98195,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8784-9949","authenticated-orcid":false,"given":"Riley J.","family":"Workman","sequence":"additional","affiliation":[{"name":"Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch 4 , Galveston, Texas 77555,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8260-9219","authenticated-orcid":false,"given":"Delaney","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Vermont 1 , Burlington, Vermont 05405,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4166-384X","authenticated-orcid":false,"given":"Uma","family":"Nudurupati","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Vermont 1 , Burlington, Vermont 05405,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6902-3978","authenticated-orcid":false,"given":"Yangguang","family":"Ou","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Vermont 1 , Burlington, Vermont 05405,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4637-9672","authenticated-orcid":false,"given":"David","family":"Punihaole","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Vermont 1 , Burlington, Vermont 05405,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"317","published-online":{"date-parts":[[2025,6,3]]},"reference":[{"key":"2025060308235902000_c1","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1146\/annurev.biochem.75.101304.123901","article-title":"Protein misfolding, functional amyloid, and human disease","volume":"75","year":"2006","journal-title":"Annu. 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