{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:54:03Z","timestamp":1777712043291,"version":"3.51.4"},"reference-count":54,"publisher":"AIP Publishing","issue":"7","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["12372062"],"award-info":[{"award-number":["12372062"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pubs.aip.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7,1]]},"abstract":"<jats:p>Some physiological experiments in Alzheimer's disease (AD) conditions have evidenced that amyloid \u03b2-peptide (A\u03b2) can induce spontaneous calcium oscillations in astrocytes and spontaneous calcium hyperactivity in astrocyte networks, which disrupt neuronal transmission and brain activity. However, the dynamical mechanism and potential process behind A\u03b2-induced spontaneous calcium dynamics have not been elucidated. Inspired by this, we develop a mathematical model of the A\u03b2-mediated astrocyte network to explore the multi-scale spontaneous calcium dynamics, where the network has a 3D multi-topology structure, including link radius, Erd\u0151s\u2013R\u00e9nyi, and scale-free networks. The A\u03b2 roles are modeled by forming new A\u03b2 membrane pores and impairing astrocyte gap junction channels. At the single-cell scale, numerical simulations demonstrate that A\u03b2 can induce astrocyte spontaneous calcium oscillations, the dynamical mechanism behind which is due to the occurrence of a subcritical Hopf bifurcation in astrocytes by means of nonlinear dynamics techniques. At the network scale, we find that A\u03b2 can induce spontaneous calcium hyperactivity in astrocyte networks by establishing quantitative metrics, which is consistent with physiological experiments of A\u03b2-induced spontaneous calcium hyperactivity in mouse cortical models. Furthermore, the double-edged effects of A\u03b2 on spontaneous calcium hyperactivity are found by analyzing the impact of A\u03b2-related parameters. Additionally, we explore the complex potential process of A\u03b2-induced spontaneous calcium hyperactivity by quantifying the key variables related to the targeted and activated astrocytes in the network. Moreover, a monotonically increasing relationship between inositol trisphosphate concentration and spontaneous calcium hyperactivity is identified. Our results offer mathematical support for experimental observations and provide insights for potential therapeutic strategies to treat abnormal spontaneous calcium dynamics in astrocytes in AD.<\/jats:p>","DOI":"10.1063\/5.0263923","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T17:53:27Z","timestamp":1753120407000},"update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":2,"title":["A<b>\u03b2<\/b>-mediated multiscale study of spontaneous calcium dynamics in astrocytes"],"prefix":"10.1063","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1532-6404","authenticated-orcid":false,"given":"YuPeng","family":"Li","sequence":"first","affiliation":[{"name":"School of Mathematics and Statistics, Shaanxi Normal University , Xi\u2019an 710062,","place":["People\u2019s Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6676-8384","authenticated-orcid":false,"given":"XiaoLi","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Mathematics and Statistics, Shaanxi Normal University , Xi\u2019an 710062,","place":["People\u2019s Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SiLu","family":"Yan","sequence":"additional","affiliation":[{"name":"School of Mathematics and Statistics, Shaanxi Normal University , Xi\u2019an 710062,","place":["People\u2019s Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9807-5186","authenticated-orcid":false,"given":"Hao","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Mathematics and Statistics, Shaanxi Normal University , Xi\u2019an 710062,","place":["People\u2019s Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"317","published-online":{"date-parts":[[2025,7,21]]},"reference":[{"key":"2025072113532452400_c1","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.1002\/alz.13016","article-title":"Alzheimer\u2019s disease facts and figures","volume":"19","year":"2023","journal-title":"Alzheimer's Dementia"},{"key":"2025072113532452400_c2","doi-asserted-by":"publisher","first-page":"543","DOI":"10.4103\/1673-5374.320970","article-title":"Pathological mechanisms and therapeutic strategies for Alzheimer\u2019s disease","volume":"17","year":"2022","journal-title":"Neural Regen. 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