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Therefore, it is imperative to design a sensor that can conveniently, rapidly, and accurately detect H2S in human blood at room temperature. In this work, we developed an Ag\/Cu2O-based sensor using a two-dimensional electrodeposition in situ assembly method for detecting biological hydrogen sulfide (bio-H2S). The morphological and structural properties indicate that a distinct contact interface has been established between Ag and Cu2O. The sensor exhibits high selectivity, good stability, and a strong linear response within the range of 50\u2013250 \u03bcM (R2 = 0.999\u200958). At room temperature, the sensor displayed a remarkable response of up to 12\u2009704.35% when exposed to 250 \u03bcM bio-H2S in blood, with a response time of just 40\u00a0s. The great sensing ability of Ag\/Cu2O nanoarray for bio-H2S detection is mainly attributed to Schottky barrier modulation of Ag\/Cu2O, catalytic sensitization of Ag nanowires, and vulcanization reaction of Cu2O. These results provide significant perspectives for the early diagnosis of chronic diseases and the real-time monitoring of blood-related diseases.<\/jats:p>","DOI":"10.1063\/5.0269480","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T10:46:43Z","timestamp":1746182803000},"update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":2,"title":["Ag\/Cu2O nanoarray sensors for rapid detection of Bio-H2S in human blood"],"prefix":"10.1063","volume":"162","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5422-711X","authenticated-orcid":false,"given":"Zheng","family":"Lu","sequence":"first","affiliation":[{"name":"School of Physics and Electrical Engineering, Linyi University , Linyi 276000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaona","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Physics and Electrical Engineering, Linyi University , Linyi 276000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2220-932X","authenticated-orcid":false,"given":"Luan","family":"Fu","sequence":"additional","affiliation":[{"name":"School of Physics and Electrical Engineering, Linyi University , Linyi 276000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3607-0679","authenticated-orcid":false,"given":"Lulu","family":"Du","sequence":"additional","affiliation":[{"name":"School of Physics and Electrical Engineering, Linyi University , Linyi 276000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5610-9775","authenticated-orcid":false,"given":"Xiaohui","family":"Shi","sequence":"additional","affiliation":[{"name":"School of Physics and Electrical Engineering, Linyi University , Linyi 276000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongchao","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Physics and Electrical Engineering, Linyi University , Linyi 276000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaifeng","family":"Xue","sequence":"additional","affiliation":[{"name":"School of Physics and Electrical Engineering, Linyi University , Linyi 276000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinhua","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Physics and Electrical Engineering, Linyi University , Linyi 276000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Lv","sequence":"additional","affiliation":[{"name":"School of Physics and Electrical Engineering, Linyi University , Linyi 276000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangliang","family":"Cui","sequence":"additional","affiliation":[{"name":"School of Physics and Electrical Engineering, Linyi University , Linyi 276000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"317","published-online":{"date-parts":[[2025,5,2]]},"reference":[{"key":"2025050206463746800_c1","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/s43856-024-00474-2","volume":"4","year":"2024","journal-title":"Commun. 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