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We address some relevant issues regarding the anomalous behavior of aqueous solutions, including the identification of their molecular-based manifestation and the rigorous interpretation according to explicit cause\u2013effect relations between the thermodynamic evidence and the molecular-based behavior in terms of the relevant fundamental structure-making\/structure-breaking functions and their temperature\/pressure derivatives. Because this novel approach involves no restrictions on the type of interactions and the nature of the species in solution, it provides a powerful tool to gain understanding of the role played by solute\u2013solvent intermolecular interaction asymmetries either in the presence or absence of hydrogen bonding interactions. Finally, we illustrate the formalism through a detailed analysis of the anomalies of aqueous ethanol solutions and test some conjectured hypotheses underlying the anomalies that point to their plausible connection to changes in the hydrogen bonding between species.<\/jats:p>","DOI":"10.1063\/5.0289066","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T10:29:40Z","timestamp":1756290580000},"update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":1,"title":["On the anomalous behavior of aqueous solutions: Rigorous formal results and the unraveling of their microstructural origin"],"prefix":"10.1063","volume":"163","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6091-4563","authenticated-orcid":false,"given":"Ariel A.","family":"Chialvo","sequence":"first","affiliation":[{"name":"Independent Researcher , Knoxville, Tennessee 37922-3108,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"317","published-online":{"date-parts":[[2025,8,27]]},"reference":[{"key":"2025082706293442600_c1","doi-asserted-by":"publisher","first-page":"R1669","DOI":"10.1088\/0953-8984\/15\/45\/r01","article-title":"Supercooled and glassy water","volume":"15","year":"2003","journal-title":"J.\u00a0Phys.: Condens. 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