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We first reproduce the spin-independent conductance\u2013distance behavior observed by Giese, Curr. Opin. Chem. Biol. 6, 612 (2002), and Lindsay, Life 10, 72 (2020), by including electron\u2013phonon interactions through Einstein phonon reservoirs at temperature T. Upon introducing spin\u2013orbit coupling under the tunneling barrier for single-stranded DNA, we obtain a clear spin-conductance asymmetry, leading to strong spin polarization (20%\u201340%) that increases with molecular length and reverses sign\u00a0with molecular chirality. The temperature dependence of the polarization exhibits a linear increase near room temperature, consistent with experimental trends. Double-stranded configurations yield similar spin-selective behavior within the experimental setup. We argue that this class of models provides the closest microscopic correspondence to current CISS measurements and that further refinements can be achieved by identifying specific decoherence processes and barrier parameters associated with each molecular system.<\/jats:p>","DOI":"10.1063\/5.0312418","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T12:23:00Z","timestamp":1769430180000},"update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":1,"title":["Spin\u2013charge transport in chirally induced spin selectivity"],"prefix":"10.1063","volume":"164","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8800-3408","authenticated-orcid":false,"given":"Valeria","family":"Bedoya","sequence":"first","affiliation":[{"name":"Departamento de F\u00edsica, Colegio de Ciencias e Ingenier\u00eda, Universidad San Francisco de Quito, Diego de Robles y Via Interoceanica 1 , Quito 17901,","place":["Ecuador"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9573-9865","authenticated-orcid":false,"given":"Horacio M.","family":"Pastawski","sequence":"additional","affiliation":[{"name":"Instituto de F\u00edsica Enrique Gaviola (CONICET-UNC), and Facultad de Matem\u00e1tica, Astronom\u00eda, F\u00edsica y Computaci\u00f3n, Universidad Nacional de C\u00f3rdoba, Ciudad Universitaria 2 , 5000 C\u00f3rdoba,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1423-6706","authenticated-orcid":false,"given":"Lucas J.","family":"Fern\u00e1ndez-Alc\u00e1zar","sequence":"additional","affiliation":[{"name":"Instituto de Modelado e Innovaci\u00f3n Tecnol\u00f3gica (CONICET-UNNE) and Facultad de Ciencias Exactas, Naturales y Agrimensura, Universidad Nacional del Nordeste 3 , Av. 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