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Direct experimental measurements of the solvation shell properties are challenging due to the strong signals generated from the bulk solvent, which overwhelm the small contribution of the solvation shell. Here, we use ultrafast two dimensional infrared (2D IR) spectroscopy and intermolecular cross-peaks to isolate the IR absorption spectrum of methanol molecules in the solvation shell surrounding the solute N-methylacetamide. We demonstrate that the intermolecular coupling between the solvent and solute vibrations is indirectly mediated by a low-frequency hydrogen-bonding mode, suggesting an important mechanism for anharmonic coupling induced by hydrogen bonds. From the relative frequency shifts and cross-peak anisotropy, we find that methanol molecules surrounding N-methylacetamide form stronger and distinctly oriented hydrogen bonds than those in the bulk solvent. We also compare these results with the solvent spectra of the solute N,N-dimethylacetamide to investigate how solute structural changes alter the solvation shell and the contribution of N\u2013H hydrogen bond donation. Our results are supported by molecular dynamics simulations, which provide detailed insights into the hydrogen-bonding distributions. Through these results, we demonstrate 2D solvation shell spectroscopy to be a valuable method for investigating solvation structures and dynamics without interference from the bulk solvent.<\/jats:p>","DOI":"10.1063\/5.0316253","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T12:16:13Z","timestamp":1774527373000},"update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["Isolating solvent\u2013solute hydrogen bonding interactions via 2D IR solvation shell spectroscopy"],"prefix":"10.1063","volume":"164","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9897-1287","authenticated-orcid":false,"given":"Samuel","family":"Knight","sequence":"first","affiliation":[{"name":"James Franck Institute, The University of Chicago 1 , Chicago, Illinois 60637,","place":["USA"]},{"name":"Department of Chemistry, The University of Chicago 2 , Chicago, Illinois 60637,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2554-0199","authenticated-orcid":false,"given":"Nicholas H. 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