{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T17:52:30Z","timestamp":1790445150199,"version":"4.1.0"},"reference-count":61,"publisher":"AIP Publishing","issue":"17","license":[{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"crossref","award":["No. TMPFP2_224947"],"award-info":[{"award-number":["No. TMPFP2_224947"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["pubs.aip.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,5,7]]},"abstract":"<jats:p>Harnessing strong light\u2013matter interactions to control chemical reactions in confined electromagnetic fields offers a promising route toward deepening our understanding of chemical dynamics at the collective quantum-mechanical level, with potential implications for future chemical synthesis paradigms. Achieving this goal, however, requires an in-depth mechanistic understanding of underlying dynamical processes. As a step in this direction, we present a systematic and numerically exact quantum dynamical study of cooperative reaction dynamics inside an optical microcavity. Using a hierarchy of model systems with increasing complexity, we elucidate how cavity-modified reactivity emerges from\u2014and is highly sensitive to\u2014subtle structural and environmental variations. Our models consist of optically dark reactive molecules, each represented by a symmetric double well potential, coupled to infrared-active non-reactive intramolecular or solvent vibrational modes, as well as their respective dissipative environments. Our results demonstrate that cavity-induced rate modifications arise from a delicate interplay among mode hybridization in strong-coupling regimes, the dynamical balance of all participating energy exchange processes, and quantum interference between multiple fluctuation\u2013dissipation-mediated reaction pathways enabled by collective cavity coupling. By continuously tuning a single system parameter or introducing molecular collectivity, we observe qualitatively distinct rate modification profiles as functions of the cavity frequency, including resonant rate enhancement, resonant rate suppression, hybridization-induced peak splitting, and, notably, asymmetric Fano-type line shapes in which enhancement peaks and suppression dips coexist within a narrow resonance window, highlighting the important role of quantum interference in cavity-modified chemical reactivity.<\/jats:p>","DOI":"10.1063\/5.0324649","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:50:52Z","timestamp":1777909852000},"update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":1,"title":["Cooperative chemical reactions in optical cavities: A complex interplay of mode hybridization, timescale balance, and pathway interference"],"prefix":"10.1063","volume":"164","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6625-3981","authenticated-orcid":false,"given":"Yaling","family":"Ke","sequence":"first","affiliation":[{"name":"Department of Chemistry and Applied Biosciences, ETH Z\u00fcrich , 8093 Z\u00fcrich,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"317","published-online":{"date-parts":[[2026,5,4]]},"reference":[{"key":"2026050411504655600_c1","doi-asserted-by":"publisher","first-page":"2403","DOI":"10.1021\/acs.accounts.6b00295","article-title":"Hybrid light\u2013matter states in a molecular and material science perspective","volume":"49","year":"2016","journal-title":"Acc. 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