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Neutron diffraction was used to track variation in the intensity of Bragg reflections originating from the crystalline pore arrangements after filling and as a function of composition and temperature. In addition, isotopic substitution was employed to systematically adjust the scattering length density contrast between the different components of the mixtures. The radial concentration profile within the pore was determined by fitting various form factor models to the experimental intensity data. At room temperature, our findings support a uniform compositional distribution within the pore. Upon cooling, we observe partial ice crystallization at Tf \u2248 200\u2013230\u00a0K in solutions where the water content exceeds the maximally freeze-concentrated solution threshold (30% w\/w), while vitrification of the entire solution is observed otherwise. The partial freezing triggers phase separation into distinct ice and liquid domains. Remarkably, the morphology adopted by these domains is shaped by the geometry of the confining cylindrical nanopore, resulting in a core\u2013shell structure: a pure ice core surrounded by a glycerol-rich layer adjacent to the pore surface. In contrast to the unfreezable layer commonly found in pure confined water, typically around 0.6\u00a0nm thick, our findings demonstrate that the size of the interfacial glassy solution is governed by both the pore size and the overall mixture composition. In the systems studied, this interfacial thickness varies between 0.3 and 1.4\u00a0nm, with its composition aligning with that of the MFCS.<\/jats:p>","DOI":"10.1063\/5.0328110","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T10:41:40Z","timestamp":1775644900000},"update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":2,"title":["Ice-induced structural reconfigurations in nanoconfined water\u2013glycerol mixtures"],"prefix":"10.1063","volume":"164","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5614-1018","authenticated-orcid":false,"given":"Mohammad Nadim","family":"Kamar","sequence":"first","affiliation":[{"name":"Institute of Physics of Rennes, CNRS-University of Rennes, UMR 6251 1 , F-35042 Rennes,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6389-8802","authenticated-orcid":false,"given":"Armin","family":"Mozhdehei","sequence":"additional","affiliation":[{"name":"Institute of Physics of Rennes, CNRS-University of Rennes, UMR 6251 1 , F-35042 Rennes,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5508-9645","authenticated-orcid":false,"given":"Ronan","family":"Lefort","sequence":"additional","affiliation":[{"name":"Institute of Physics of Rennes, CNRS-University of Rennes, UMR 6251 1 , F-35042 Rennes,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0873-037X","authenticated-orcid":false,"given":"Christiane","family":"Alba-Simionesco","sequence":"additional","affiliation":[{"name":"Laboratoire L\u00e9on Brillouin, CEA, CNRS, Universit\u00e9 Paris-Saclay 2 , F-91191 Gif-sur-Yvette,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3608-9222","authenticated-orcid":false,"given":"Viviana","family":"Cristiglio","sequence":"additional","affiliation":[{"name":"Institut Laue-Langevin 3 , 71 Avenue des Martyrs, F-38000 Grenoble,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8784-3021","authenticated-orcid":false,"given":"Denis","family":"Morineau","sequence":"additional","affiliation":[{"name":"Institute of Physics of Rennes, CNRS-University of Rennes, UMR 6251 1 , F-35042 Rennes,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"317","published-online":{"date-parts":[[2026,4,8]]},"reference":[{"issue":"6397","key":"2026040806412127600_c1","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1038\/359710a0","article-title":"Ordered mesoporous molecular sieves synthesized by a liquid-crystal template mechanism","volume":"359","year":"1992","journal-title":"Nature"},{"issue":"5350","key":"2026040806412127600_c2","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1126\/science.279.5350.548","article-title":"Triblock copolymer syntheses of mesoporous silica with periodic 50 to 300 Angstrom pores","volume":"279","year":"1998","journal-title":"Science"},{"issue":"24","key":"2026040806412127600_c3","doi-asserted-by":"publisher","first-page":"6024","DOI":"10.1021\/ja974025i","article-title":"Nonionic triblock and star diblock copolymer and oligomeric surfactant syntheses of highly ordered, hydrothermally stable, mesoporous silica structures","volume":"120","year":"1998","journal-title":"J.\u00a0Am. 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