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Consequently, a major challenge in statistical physics is to uncover the universal principles governing macromolecular self-organization within the crowded, non-equilibrium environment of the cell. Here, we investigate a class of models where molecules maintain a conserved total concentration but can switch \u201cidentities,\u201d thereby modulating their intermolecular interactions. By enforcing thermodynamic consistency via the local detailed balance condition, we derive the steady-state criteria determining coexisting concentrations in a binary mixture. In particular, local detailed balance together with state-dependent kinetics impose a difference in chemical potentials across the interface, and we obtain jump conditions that generalize Gibbs\u2019 equilibrium coexistence criteria of equal pressure and chemical potential to chemically driven steady states. 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