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To illustrate the versatility of the model, this study systematically varies the spacing between hydrogen-bonding monomers using an i \u2192 i + m motif, with m = 4, 5, and 6 corresponding to coarse-grained representations of \u03b1-, \u03c0-, and 1\u20137 helices. This approach is used to evaluate how hydrogen-bond spacing influences the transition behavior and the resulting cooperativity. As the monomer spacing m between hydrogen-bonding pairs increases, the number of monomers that must be confined for the first hydrogen bond to form also increases, leading to increased cooperativity (lower nucleation parameter \u03c3) and a sharper transition, as reflected in the simulation results. This behavior is consistent with that observed in natural helices of different types, underscoring the model\u2019s ability to capture how molecular architecture governs helix formation.<\/jats:p>","DOI":"10.1063\/5.0336712","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T16:01:41Z","timestamp":1786550501000},"update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":1,"title":["Coil\u2013helix transition in macromolecules. I. 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