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Alongside the design of the ultra-high-pressure reactor, we also outline the structure of the three-layer steel reaction chamber. This apparatus was specifically developed for organic synthesis in the liquid phase and allows precise control of pressure and temperature\u2014critical factors for optimizing reaction conditions. A key engineering achievement of this apparatus is its ability to facilitate reactions with standard solvents (such as methanol and dichloromethane) across a pressure range from atmospheric pressure to 23 kbar and at temperatures ranging from room temperature to 150\u2009\u00b0C. Two representative examples demonstrate the use of the developed device in organic synthesis.<\/jats:p>","DOI":"10.1063\/5.0337801","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:39:40Z","timestamp":1791203980000},"update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["Piston-cylinder apparatus with a working volume of 22\u00a0cm3 and pressure up to 23 kbar for ultra-high-pressure synthesis in the liquid phase"],"prefix":"10.1063","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5094-9220","authenticated-orcid":false,"given":"A. G.","family":"Kutasevich","sequence":"first","affiliation":[{"name":"RUDN University 1 , 6 Miklukho-Maklaya St., Moscow 117198,","place":["Russian Federation"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9637-6653","authenticated-orcid":false,"given":"Y. 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