{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T11:01:13Z","timestamp":1781262073106,"version":"3.54.1"},"reference-count":57,"publisher":"AIP Publishing","issue":"22","funder":[{"name":"Phenikaa Innovation Foundation","award":["\u0110MST.2022.03"],"award-info":[{"award-number":["\u0110MST.2022.03"]}]}],"content-domain":{"domain":["pubs.aip.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,6,14]]},"abstract":"<jats:p>Gliclazide (GLZ) is a sulfonylurea antidiabetic drug widely used to treat type 2 diabetes mellitus. However, its poor aqueous solubility is a major challenge in drug formulation, often limiting the bioavailability and therapeutic efficacy. In this study, we explore the application of atomic layer deposition (ALD) as a surface engineering technique to enhance the wettability and tailor the dissolution of GLZ. By coating the drug particles with ultra-thin SiO2 films, their wettability is transformed from strongly hydrophobic to highly hydrophilic, promoting a highly dispersed state in an aqueous medium and significantly accelerating the dissolution. More importantly, by controlling the coating thickness, the dissolution rate of GLZ can be tailored, enabling tunable drug dissolution profiles. The results demonstrate the potential of SiO2 ALD not only in overcoming solubility-related limitations but also in providing a method of multipurpose design for controlled drug delivery. Given its compatibility with pharmaceutical manufacturing, our approach presents a promising pathway to enhance bioavailability and optimize the release kinetics of other poorly soluble drugs.<\/jats:p>","DOI":"10.1063\/5.0340896","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T10:29:32Z","timestamp":1781260172000},"update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["Tunable dissolution of poorly soluble gliclazide by surface coating via room-temperature atomic layer deposition"],"prefix":"10.1063","volume":"164","author":[{"given":"Viet Phuong","family":"Cao","sequence":"first","affiliation":[{"name":"Faculty of Materials Science and Engineering, Phenikaa School of Engineering, Phenikaa University 1 , Hanoi 12116,","place":["Vietnam"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Truong Duc","family":"Dinh","sequence":"additional","affiliation":[{"name":"Faculty of Materials Science and Engineering, Phenikaa School of Engineering, Phenikaa University 1 , Hanoi 12116,","place":["Vietnam"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diem-Quyen T.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Faculty of Materials Science and Engineering, Phenikaa School of Engineering, Phenikaa University 1 , Hanoi 12116,","place":["Vietnam"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung-Jin","family":"Jung","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, Pusan National University 2 , 30 Jangjeon-Dong Geumjeong-Gu, Busan 46241,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2286-1824","authenticated-orcid":false,"given":"Se-Hun","family":"Kwon","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, Pusan National University 2 , 30 Jangjeon-Dong Geumjeong-Gu, Busan 46241,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuan Hiep","family":"Tran","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Phenikaa School of Medicine and Pharmacy, Phenikaa University 3 , Hanoi 12116,","place":["Vietnam"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8460-1409","authenticated-orcid":false,"given":"Hao","family":"Van Bui","sequence":"additional","affiliation":[{"name":"Faculty of Materials Science and Engineering, Phenikaa School of Engineering, Phenikaa University 1 , Hanoi 12116,","place":["Vietnam"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"317","published-online":{"date-parts":[[2026,6,12]]},"reference":[{"key":"2026061206292888700_c1","doi-asserted-by":"publisher","first-page":"108086","DOI":"10.1016\/j.diabres.2020.108086","article-title":"Mortality attributable to diabetes in 20\u201379 years old adults, 2019 estimates: Results from the international diabetes Federation diabetes atlas, 9th edition","volume":"162","year":"2020","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"9","key":"2026061206292888700_c2","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1038\/s41574-022-00690-7","article-title":"The burden and risks of emerging complications of diabetes mellitus","volume":"18","year":"2022","journal-title":"Nat. Rev. Endocrinol."},{"key":"2026061206292888700_c3","doi-asserted-by":"publisher","first-page":"107843","DOI":"10.1016\/j.diabres.2019.107843","article-title":"Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the international diabetes Federation diabetes atlas, 9th edition","volume":"157","year":"2019","journal-title":"Diabetes Res. Clin. Pract."},{"key":"2026061206292888700_c4","doi-asserted-by":"publisher","first-page":"115734","DOI":"10.1016\/j.biopha.2023.115734","article-title":"Diabetes mellitus: Classification, mediators, and complications; A gate to identify potential targets for the development of new effective treatments","volume":"168","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"15","key":"2026061206292888700_c5","doi-asserted-by":"publisher","first-page":"3789","DOI":"10.1016\/j.cell.2024.06.029","article-title":"Diabetes mellitus\u2014Progress and opportunities in the evolving epidemic","volume":"187","year":"2024","journal-title":"Cell"},{"issue":"6865","key":"2026061206292888700_c6","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1038\/414782a","article-title":"Global and societal implications of the diabetes epidemic","volume":"414","year":"2001","journal-title":"Nature"},{"key":"2026061206292888700_c7","first-page":"125","article-title":"Chapter three-gliclazide","volume-title":"Profiles of Drug Substances, Excipients, and Related Methodology","author":"Brittain","year":"2017"},{"key":"2026061206292888700_c8","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.diabres.2015.11.001","article-title":"Implementing an optimized glucose-lowering strategy with a novel once daily modified release gliclazide formulation","volume":"112","year":"2016","journal-title":"Diabetes Res. Clin. Pract."},{"key":"2026061206292888700_c9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.diabres.2018.05.028","article-title":"The place of gliclazide MR in the evolving type 2 diabetes landscape: A comparison with other sulfonylureas and newer oral antihyperglycemic agents","volume":"143","year":"2018","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"1","key":"2026061206292888700_c10","doi-asserted-by":"publisher","first-page":"92","DOI":"10.2165\/00003495-199346010-00007","article-title":"Gliclazide","volume":"46","year":"1993","journal-title":"Drugs"},{"issue":"9","key":"2026061206292888700_c11","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.3390\/pharmaceutics14091947","article-title":"Pharmacokinetics and anti-diabetic studies of gliclazide nanosuspension","volume":"14","year":"2022","journal-title":"Pharmaceutics"},{"issue":"3","key":"2026061206292888700_c12","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.powtec.2008.02.018","article-title":"Dissolution enhancement of gliclazide using in situ micronization by solvent change method","volume":"187","year":"2008","journal-title":"Powder Technol."},{"issue":"1","key":"2026061206292888700_c13","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s13098-018-0331-8","article-title":"Effectiveness of gliclazide MR 60 mg in the management of type 2 diabetes: Analyses from the EASYDia trial","volume":"10","year":"2018","journal-title":"Diabetol. Metab. Syndr."},{"issue":"2","key":"2026061206292888700_c14","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1208\/s12249-008-9079-z","article-title":"Enhancement of dissolution rate of gliclazide using solid dispersions with polyethylene glycol 6000","volume":"9","year":"2008","journal-title":"AAPS PharmSciTech"},{"issue":"2","key":"2026061206292888700_c15","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s12247-024-09817-x","article-title":"In vitro profiling of gliclazide-loaded aerosil 380 solid dispersion\u2013based tablets with co-processed excipients","volume":"19","year":"2024","journal-title":"J.\u00a0Pharm. Innov."},{"issue":"3","key":"2026061206292888700_c16","doi-asserted-by":"publisher","first-page":"262","DOI":"10.4103\/jpbs.jpbs_87_18","article-title":"Study of gliclazide solid dispersion systems using PVP K-30 and PEG 6000 by solvent method","volume":"11","year":"2019","journal-title":"J.\u00a0Pharm. BioAllied Sci."},{"issue":"13","key":"2026061206292888700_c17","doi-asserted-by":"publisher","first-page":"2275","DOI":"10.1039\/c5ce02402a","article-title":"Novel cocrystals of gliclazide: Characterization and evaluation","volume":"18","year":"2016","journal-title":"CrystEngComm"},{"issue":"2\u20133","key":"2026061206292888700_c18","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/s0168-3659(97)00167-3","article-title":"Accelerated oral absorption of gliclazide in human subjects from a soft gelatin capsule containing a PEG 400 suspension of gliclazide","volume":"51","year":"1998","journal-title":"J.\u00a0Controlled Release"},{"key":"2026061206292888700_c19","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.2147\/ijn.s235290","article-title":"Lipid-based gliclazide nanoparticles for treatment of diabetes: Formulation, pharmacokinetics, pharmacodynamics and subacute toxicity study","volume":"15","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"2026061206292888700_c20","doi-asserted-by":"publisher","first-page":"115634","DOI":"10.1016\/j.jpba.2023.115634","article-title":"Drug-excipient compatibility studies in formulation development: A case study with benznidazole and monoglycerides","volume":"235","year":"2023","journal-title":"J.\u00a0Pharm. Biomed. Anal."},{"issue":"1","key":"2026061206292888700_c21","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.ijpharm.2017.04.031","article-title":"Surface modification of acetaminophen particles by atomic layer deposition","volume":"525","year":"2017","journal-title":"Int. J. Pharm."},{"issue":"32","key":"2026061206292888700_c22","doi-asserted-by":"publisher","first-page":"11410","DOI":"10.1039\/c7nr03261g","article-title":"Atomic scale surface engineering of micro- to nano-sized pharmaceutical particles for drug delivery applications","volume":"9","year":"2017","journal-title":"Nanoscale"},{"issue":"1\u20132","key":"2026061206292888700_c23","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.ijpharm.2017.06.046","article-title":"Production and characterization of aluminium oxide nanoshells on spray dried lactose","volume":"529","year":"2017","journal-title":"Int. J. Pharm."},{"key":"2026061206292888700_c24","doi-asserted-by":"publisher","first-page":"15845","DOI":"10.1039\/D5RA07278F","article-title":"Surface engineering and functionalization of powder-based materials by fluidized-bed atomic layer deposition for emerging applications","volume":"16","year":"2026","journal-title":"RSC Adv."},{"issue":"4","key":"2026061206292888700_c25","doi-asserted-by":"publisher","first-page":"6684","DOI":"10.1021\/acsnano.0c10040","article-title":"Controlled pulmonary delivery of carrier-free budesonide dry powder by atomic layer deposition","volume":"15","year":"2021","journal-title":"ACS Nano"},{"issue":"23","key":"2026061206292888700_c26","doi-asserted-by":"publisher","first-page":"27195","DOI":"10.1021\/acsami.2c05761","article-title":"Atomic layer deposition coating on the surface of active pharmaceutical ingredients to reduce surface charge build-up","volume":"14","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"2026061206292888700_c27","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.ejpb.2019.04.019","article-title":"Nanoshells prepared by atomic layer deposition\u2014Long acting depots of indomethacin","volume":"140","year":"2019","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"2026061206292888700_c28","doi-asserted-by":"publisher","first-page":"162283","DOI":"10.1016\/j.apsusc.2024.162283","article-title":"Toward extended release of metformin by room-temperature atomic layer deposition of thin SiO2 films","volume":"687","year":"2025","journal-title":"Appl. Surf. Sci."},{"issue":"1","key":"2026061206292888700_c29","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1021\/acs.molpharmaceut.2c00818","article-title":"Impact of aluminum oxide nanocoating on drug release from amorphous solid dispersion particles","volume":"20","year":"2023","journal-title":"Mol. Pharm."},{"key":"2026061206292888700_c30","doi-asserted-by":"publisher","first-page":"121747","DOI":"10.1016\/j.ijpharm.2022.121747","article-title":"Surface nanocoating of high drug-loading spray-dried amorphous solid dispersions by atomic layer coating: Excellent physical stability under accelerated storage conditions for two years","volume":"620","year":"2022","journal-title":"Int. J. Pharm."},{"issue":"1","key":"2026061206292888700_c31","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.xphs.2024.10.001","article-title":"Dissolution of copovidone-based amorphous solid dispersions: Influence of atomic layer coating, hydration kinetics, and formulation","volume":"114","year":"2025","journal-title":"J.\u00a0Pharm. Sci."},{"issue":"36","key":"2026061206292888700_c32","doi-asserted-by":"publisher","first-page":"40698","DOI":"10.1021\/acsami.2c12666","article-title":"Atomic layer coating to inhibit surface crystallization of amorphous pharmaceutical powders","volume":"14","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"1","key":"2026061206292888700_c33","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/s41541-020-0195-4","article-title":"Single-administration, thermostable human papillomavirus vaccines prepared with atomic layer deposition technology","volume":"5","year":"2020","journal-title":"npj Vaccines"},{"issue":"5","key":"2026061206292888700_c34","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1016\/j.xphs.2022.01.013","article-title":"Atomic-layer deposition processes applied to phage \u03bb and a phage-like particle platform yield thermostable, single-shot vaccines","volume":"111","year":"2022","journal-title":"J.\u00a0Pharm. Sci."},{"issue":"8","key":"2026061206292888700_c35","doi-asserted-by":"publisher","first-page":"2223","DOI":"10.1016\/j.xphs.2023.02.007","article-title":"A single dose, thermostable, trivalent human Papillomavirus vaccine formulated using atomic layer deposition","volume":"112","year":"2023","journal-title":"J.\u00a0Pharm. Sci."},{"issue":"7","key":"2026061206292888700_c36","doi-asserted-by":"publisher","first-page":"761","DOI":"10.3390\/vaccines12070761","article-title":"Demonstration of tunable control over a delayed-release vaccine using atomic layer deposition","volume":"12","year":"2024","journal-title":"Vaccines"},{"key":"2026061206292888700_c37","doi-asserted-by":"publisher","first-page":"142131","DOI":"10.1016\/j.cej.2023.142131","article-title":"Tailoring the flow properties of inhaled micronized drug powders by atomic and molecular layer deposition","volume":"462","year":"2023","journal-title":"Chem. Eng. J."},{"key":"2026061206292888700_c38","doi-asserted-by":"publisher","first-page":"118525","DOI":"10.1016\/j.powtec.2023.118525","article-title":"Improving the processability of pharmaceutical powders using atomic layer coating","volume":"425","year":"2023","journal-title":"Powder Technol."},{"key":"2026061206292888700_c39","doi-asserted-by":"publisher","first-page":"100945","DOI":"10.1016\/j.apmt.2021.100945","article-title":"Drug powders with tunable wettability by atomic and molecular layer deposition: From highly hydrophilic to superhydrophobic","volume":"22","year":"2021","journal-title":"Appl. Mater. Today"},{"issue":"33","key":"2026061206292888700_c40","doi-asserted-by":"publisher","first-page":"6186","DOI":"10.1039\/d4cc06707j","article-title":"Stable dispersion and prolonged dissolution of hydrophilic pharmaceutical achieved by room-temperature atmospheric pressure atomic layer deposition","volume":"61","year":"2025","journal-title":"Chem. Commun."},{"issue":"1","key":"2026061206292888700_c41","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/j.xphs.2024.10.052","article-title":"Bioavailability improvement by atomic layer coating: Fenofibrate a case study","volume":"114","year":"2025","journal-title":"J.\u00a0Pharm. Sci."},{"issue":"8","key":"2026061206292888700_c42","doi-asserted-by":"publisher","first-page":"4086","DOI":"10.1021\/acs.molpharmaceut.3c00229","article-title":"Effect of atomic layer coating on the stability of solid myoglobin formulations","volume":"20","year":"2023","journal-title":"Mol. Pharm."},{"issue":"10","key":"2026061206292888700_c43","doi-asserted-by":"publisher","first-page":"4802","DOI":"10.1021\/acs.molpharmaceut.3c00526","article-title":"Crystallinity: A complex critical quality attribute of amorphous solid dispersions","volume":"20","year":"2023","journal-title":"Mol. Pharm."},{"issue":"8","key":"2026061206292888700_c44","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1109\/LED.2010.2049978","article-title":"High-quality low-temperature silicon oxide by plasma-enhanced atomic layer deposition using a metal\u2013organic silicon precursor and oxygen radical","volume":"31","year":"2010","journal-title":"IEEE Electron Device Lett."},{"issue":"1","key":"2026061206292888700_c45","doi-asserted-by":"publisher","first-page":"34","DOI":"10.4103\/0250-474x.151595","article-title":"Preparation and crystallographic analysis of gliclazide polymorphs","volume":"77","year":"2015","journal-title":"Indian J. Pharm. Sci."},{"issue":"1","key":"2026061206292888700_c46","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1186\/s43094-021-00261-z","article-title":"Cocrystallization of gliclazide with improved physicochemical properties","volume":"7","year":"2021","journal-title":"Future J. Pharmaceut. Sci."},{"key":"2026061206292888700_c47","doi-asserted-by":"publisher","first-page":"147244","DOI":"10.1016\/j.apsusc.2020.147244","article-title":"Tuning the photocatalytic activity of TiO2 nanoparticles by ultrathin SiO2 films grown by low-temperature atmospheric pressure atomic layer deposition","volume":"530","year":"2020","journal-title":"Appl. Surf. Sci."},{"issue":"3","key":"2026061206292888700_c48","doi-asserted-by":"publisher","first-page":"419","DOI":"10.15171\/apb.2018.049","article-title":"Fabrication and characterization of gliclazide nanocrystals","volume":"8","year":"2018","journal-title":"Adv. Pharm. Bull."},{"issue":"4","key":"2026061206292888700_c49","first-page":"127","article-title":"In-Depth qualitative and quantitative FTIR spectroscopic study of glipizide and gliclazide","volume":"14","year":"2014","journal-title":"Anal. Chem. Indian J."},{"issue":"3","key":"2026061206292888700_c50","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1063\/1.371996","article-title":"Rapid thermal annealing effects on the structural properties and density of defects in SiO2 and SiNx:H films deposited by electron cyclotron resonance","volume":"87","year":"2000","journal-title":"J.\u00a0Appl. Phys."},{"issue":"8","key":"2026061206292888700_c51","doi-asserted-by":"publisher","first-page":"3689","DOI":"10.1016\/j.apsusc.2011.12.006","article-title":"Synthesis and characterization of core\u2013shell structured SiO2@YVO4:Yb3+,Er3+ microspheres","volume":"258","year":"2012","journal-title":"Appl. Surf. Sci."},{"key":"2026061206292888700_c52","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1016\/j.saa.2016.09.037","article-title":"UV\u2013VIS absorption spectroscopy: Lambert\u2013Beer reloaded","volume":"173","year":"2017","journal-title":"Spectrochim. Acta, Part A"},{"issue":"11","key":"2026061206292888700_c53","doi-asserted-by":"publisher","first-page":"113649","DOI":"10.1016\/j.isci.2025.113649","article-title":"Broad anti-sarbecovirus responses elicited by a single administration of mosaic-8 RBD-nanoparticle vaccine prepared using atomic layer deposition","volume":"28","year":"2025","journal-title":"iScience"},{"key":"2026061206292888700_c54","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.colsurfb.2012.08.017","article-title":"Dissolution process analysis using model-free Noyes\u2013Whitney integral equation","volume":"102","year":"2013","journal-title":"Colloids Surf., B"},{"key":"2026061206292888700_c55","doi-asserted-by":"publisher","first-page":"106556","DOI":"10.1016\/j.ejps.2023.106556","article-title":"Lipid based formulations as supersaturating oral delivery systems: From current to future industrial applications","volume":"189","year":"2023","journal-title":"Eur. J. Pharm. Sci."},{"key":"2026061206292888700_c56","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1055\/s-0032-1333242","article-title":"Serum concentrations and hypoglycemic effect of gliclazide: Crosspovidone solid dispersion on streptozotocin induced diabetic rats","volume":"63","year":"2013","journal-title":"Drug Res."},{"key":"2026061206292888700_c57","first-page":"125","article-title":"Gliclazide","volume-title":"Profiles of Drug Substances, Excipients, and Related Methodology","year":"2017"}],"container-title":["The Journal of Chemical Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.aip.org\/aip\/jcp\/article-pdf\/doi\/10.1063\/5.0340896\/21037411\/224711_1_5.0340896.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.aip.org\/aip\/jcp\/article-pdf\/doi\/10.1063\/5.0340896\/21037411\/224711_1_5.0340896.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T10:29:33Z","timestamp":1781260173000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.aip.org\/jcp\/article\/164\/22\/224711\/3394525\/Tunable-dissolution-of-poorly-soluble-gliclazide"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,12]]},"references-count":57,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2026,6,14]]}},"URL":"https:\/\/doi.org\/10.1063\/5.0340896","relation":{},"ISSN":["0021-9606","1089-7690"],"issn-type":[{"value":"0021-9606","type":"print"},{"value":"1089-7690","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,6,14]]},"published":{"date-parts":[[2026,6,12]]},"article-number":"224711"}}