{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T23:59:27Z","timestamp":1786492767459,"version":"build-2736575974"},"reference-count":18,"publisher":"AIP Publishing","issue":"7","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["T2125011"],"award-info":[{"award-number":["T2125011"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002367","name":"The Chinese Academy of Sciences","doi-asserted-by":"crossref","award":["YSBR-068"],"award-info":[{"award-number":["YSBR-068"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Innovation Program for Quantum Science and Technology","award":["2021ZD0302200"],"award-info":[{"award-number":["2021ZD0302200"]}]},{"name":"Innovation Program for Quantum Science and Technology","award":["2021ZD0303204"],"award-info":[{"award-number":["2021ZD0303204"]}]},{"name":"New Cornerstone Science Foundation Through the XPLORER PRIZE"},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["pubs.aip.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:p>Nitrogen-vacancy (NV) centers in diamond enable Nuclear Magnetic Resonance (NMR) spectroscopy from picoliter-scale samples, providing a route toward volume-limited magnetic resonance measurements. However, achieving high spectral resolution in a compact integrated spectrometer remains challenging, particularly under ambient magnetic noise. Here, we present an integrated NV-NMR spectrometer based on a compact multilayer architecture that combines a diamond sensor, an ultrathin Printed Circuit Board antenna, a sealed liquid-sample chamber, and a custom permanent magnet. In this sealed-chamber configuration, the spectrometer operates with an estimated detection volume on the order of ten picoliters, achieves a magnetic sensitivity of 27 pT\/Hz, and uses hyperpolarization to improve NMR signal detectability. The system further incorporates a dual-stabilization scheme based on asynchronous fluxgate monitoring and synchronous optically detected magnetic resonance drift tracking, enabling high-resolution operation under ambient field-induced proton-frequency shifts of up to \u00b140\u00a0Hz. Under ambient conditions, without heavy magnetic shielding or strict temperature control, the spectrometer achieves a proton NMR linewidth of 2.34 \u00b1 0.05 Hz, corresponding to 0.450.01 ppm. These results establish a compact integrated architecture for high-resolution picoliter NMR under nonideal laboratory magnetic environments.<\/jats:p>","DOI":"10.1063\/5.0343440","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T12:56:36Z","timestamp":1784120196000},"update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":1,"title":["Integrated diamond quantum spectrometer for high-resolution picoliter nuclear magnetic resonance (NMR) under ambient magnetic noise"],"prefix":"10.1063","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1934-1951","authenticated-orcid":false,"given":"Mengze","family":"Shen","sequence":"first","affiliation":[{"name":"Laboratory of Spin Magnetic Resonance, School of Physical Sciences, Anhui Province Key Laboratory of Scientific Instrument Development and Application, University of Science and Technology of China 1 , Hefei 230026,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1465-0269","authenticated-orcid":false,"given":"Zhiyuan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Laboratory of Spin Magnetic Resonance, School of Physical Sciences, Anhui Province Key Laboratory of Scientific Instrument Development and Application, University of Science and Technology of China 1 , Hefei 230026,","place":["China"]},{"name":"Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China 2 , Hefei 230026,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9171-7974","authenticated-orcid":false,"given":"Yuhan","family":"Luo","sequence":"additional","affiliation":[{"name":"Laboratory of Spin Magnetic Resonance, School of Physical Sciences, Anhui Province Key Laboratory of Scientific Instrument Development and Application, University of Science and Technology of China 1 , Hefei 230026,","place":["China"]},{"name":"Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China 2 , Hefei 230026,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junteng","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of Spin Magnetic Resonance, School of Physical Sciences, Anhui Province Key Laboratory of Scientific Instrument Development and Application, University of Science and Technology of China 1 , Hefei 230026,","place":["China"]},{"name":"School of Biomedical Engineering and Suzhou Institute for Advanced Research, University of Science and Technology of China 3 , Suzhou 215123,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Laboratory of Spin Magnetic Resonance, School of Physical Sciences, Anhui Province Key Laboratory of Scientific Instrument Development and Application, University of Science and Technology of China 1 , Hefei 230026,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3312-5566","authenticated-orcid":false,"given":"Fazhan","family":"Shi","sequence":"additional","affiliation":[{"name":"Laboratory of Spin Magnetic Resonance, School of Physical Sciences, Anhui Province Key Laboratory of Scientific Instrument Development and Application, University of Science and Technology of China 1 , Hefei 230026,","place":["China"]},{"name":"Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China 2 , Hefei 230026,","place":["China"]},{"name":"School of Biomedical Engineering and Suzhou Institute for Advanced Research, University of Science and Technology of China 3 , Suzhou 215123,","place":["China"]},{"name":"Hefei National Laboratory, University of Science and Technology of China 4 , Hefei 230088,","place":["China"]},{"name":"The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China 5 , Hefei 230026,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"317","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"key":"2026071508563044000_c1","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.pnmrs.2021.09.001","article-title":"Synergies between hyperpolarized NMR and microfluidics: A review","volume":"128","year":"2022","journal-title":"Prog. 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