{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T12:20:30Z","timestamp":1788351630825,"version":"build-2803163510"},"reference-count":66,"publisher":"AIP Publishing","issue":"9","funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2025-06298"],"award-info":[{"award-number":["RGPIN-2025-06298"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pubs.aip.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,9,7]]},"abstract":"<jats:p>We investigate the structure and dynamics of a polymer in a fluid containing mobile spherical colloidal crowders of radius R. We compare and contrast the behavior with Langevin dynamics (LD) and lattice Boltzmann molecular dynamics (LBMD), the latter incorporating long-range hydrodynamic interactions. Both the colloid size relative to the monomer radius r and the volume fraction \u03d5 are varied to determine how crowding modifies polymer behavior. Increasing volume fraction induces polymer compaction, with the mechanism strongly dependent on the size ratio R\/r. Small colloids primarily modify the short-wavelength polymer conformation, causing self-avoiding-walk-like behavior to persist to shorter length scales, whereas large colloids reduce the effective long-wavelength Flory exponent, indicating a degraded solvent quality consistent with a confinement-blob picture. Polymer diffusion exhibits distinct behavior in LD and LBMD. In LD, diffusion decreases rapidly and depends strongly on R\/r; a phenomenological scaling involving ln(1 + R\/r) captures this size dependence, and additional scaling with Rg reduces scatter, indicating polymer-scale correlations induced by crowding. In contrast, LBMD diffusion follows an effective-medium\u2013like exponential dependence on concentration, governed by hydrodynamic coupling. Rouse-mode analysis identifies three regimes: scaling breakdown at low volume fraction, Zimm-like behavior at intermediate density in both LD and LBMD, and, at high density, hydrodynamic screening in LBMD with confinement-dominated dynamics in LD.<\/jats:p>","DOI":"10.1063\/5.0343922","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:51:29Z","timestamp":1788349889000},"update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["Dynamical and conformational behavior of a polymer in a crowded solution"],"prefix":"10.1063","volume":"165","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2495-064X","authenticated-orcid":false,"given":"Setarehalsadat","family":"Changizrezaei","sequence":"first","affiliation":[{"name":"Department of Physics and Astronomy, The University of Western Ontario , London, Ontario N6A 3K7,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6723-0455","authenticated-orcid":false,"given":"Colin","family":"Denniston","sequence":"additional","affiliation":[{"name":"Department of Physics and Astronomy, The University of Western Ontario , London, Ontario N6A 3K7,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"317","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"key":"2026090207512012600_c1","doi-asserted-by":"publisher","first-page":"134910","DOI":"10.1063\/1.1874852","volume":"122","year":"2005","journal-title":"J.\u00a0Chem. 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