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Following extraction and characterization of CO@OMVs, in vitro experiments in RAW 264.7 macrophages demonstrated increased levels of cGAS\u2013STING-associated signaling molecules, enhanced mitophagy, increased tumor necrosis factor-\u03b1 (TNF-\u03b1) secretion, and decreased IL-6 secretion. In a CIRI mouse model, CO@OMVs reduced local inflammatory markers and apoptosis and improved cognitive and neurobehavioral functions. 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