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OTfU is a derivative of uracil with a triflate (OTf) group at the C5-position, which substantially increases its ability to undergo effective electron-induced dissociation. We report a rich assortment of fragments formed upon dissociative electron attachment (DEA), mostly by simple bond cleavages (e.g., dehydrogenation or formation of OTf\u2212). The most favorable DEA channel corresponds to the formation of the triflate anion alongside with the reactive uracil-5-yl radical through the cleavage of the O\u2013C5 bond, particularly at about 0 eV. Unlike for halouracils, the parent anion was not detected in our experiments. The experimental findings are accounted by a comprehensive theoretical study carried out at the M06-2X\/aug-cc-pVTZ level. The latter comprises the thermodynamic thresholds for the formation of the observed anions calculated under the experimental conditions (383.15 K and 3 \u00d7 10\u221211 atm). The energy-resolved ion yield of the dehydrogenated parent anion, (OTfU\u2013H)\u2212, is discussed in terms of vibrational Feshbach resonances arising from the coupling between the dipole bound state and vibrational levels of the transient negative ion. We also report the mass spectrum of the cations obtained through ionization of OTfU by electrons with a kinetic energy of 70 eV. The current study endorses OTfU as a potential radiosensitizer agent with possible applications in radio-chemotherapy.<\/jats:p>","DOI":"10.1063\/1.5050594","type":"journal-article","created":{"date-parts":[[2018,10,29]],"date-time":"2018-10-29T15:39:31Z","timestamp":1540827571000},"update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":37,"title":["Low-energy electron-induced decomposition of 5-trifluoromethanesulfonyl-uracil: A potential radiosensitizer"],"prefix":"10.1063","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8648-9924","authenticated-orcid":false,"given":"J.","family":"Ameixa","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Ionenphysik und Angewandte Physik and Center for Molecular Biosciences (CMBI), Leopold\u2013Franzens Universit\u00e4t Innsbruck 1 , Technikerstra\u00dfe 25\/3, 6020 Innsbruck, Austria"},{"name":"Laborat\u00f3rio de Colis\u00f5es At\u00f3micas e Moleculares, CEFITEC, Departamento de F\u00edsica, Faculdade de Ci\u00eancias e Tecnologia, Universidade NOVA de Lisboa, Campus de Caparica 2 , 2829-516 Caparica, Portugal"}]},{"given":"E.","family":"Arthur-Baidoo","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Ionenphysik und Angewandte Physik and Center for Molecular Biosciences (CMBI), Leopold\u2013Franzens Universit\u00e4t Innsbruck 1 , Technikerstra\u00dfe 25\/3, 6020 Innsbruck, Austria"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3928-8964","authenticated-orcid":false,"given":"R.","family":"Mei\u00dfner","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Ionenphysik und Angewandte Physik and Center for Molecular Biosciences (CMBI), Leopold\u2013Franzens Universit\u00e4t Innsbruck 1 , Technikerstra\u00dfe 25\/3, 6020 Innsbruck, Austria"},{"name":"Laborat\u00f3rio de Colis\u00f5es At\u00f3micas e Moleculares, CEFITEC, Departamento de F\u00edsica, Faculdade de Ci\u00eancias e Tecnologia, Universidade NOVA de Lisboa, Campus de Caparica 2 , 2829-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2907-7725","authenticated-orcid":false,"given":"S.","family":"Makurat","sequence":"additional","affiliation":[{"name":"Laboratory of Biological Sensitizers, Physical Chemistry Department, Faculty of Chemistry, University of Gda\u0144sk 3 , 80-308 Gda\u0144sk, Poland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3253-5555","authenticated-orcid":false,"given":"W.","family":"Kozak","sequence":"additional","affiliation":[{"name":"Laboratory of Biological Sensitizers, Physical Chemistry Department, Faculty of Chemistry, University of Gda\u0144sk 3 , 80-308 Gda\u0144sk, Poland"}]},{"given":"K.","family":"Butowska","sequence":"additional","affiliation":[{"name":"Laboratory of Biophysics, Department of Molecular and Cellular Biology, Intercollegiate Faculty of Biotechnology of the University of Gda\u0144sk and Medical University of Gda\u0144sk 4 , 80-307 Gda\u0144sk, Poland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2182-2965","authenticated-orcid":false,"given":"F.","family":"Ferreira da Silva","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Colis\u00f5es At\u00f3micas e Moleculares, CEFITEC, Departamento de F\u00edsica, Faculdade de Ci\u00eancias e Tecnologia, Universidade NOVA de Lisboa, Campus de Caparica 2 , 2829-516 Caparica, Portugal"}]},{"given":"J.","family":"Rak","sequence":"additional","affiliation":[{"name":"Laboratory of Biological Sensitizers, Physical Chemistry Department, Faculty of Chemistry, University of Gda\u0144sk 3 , 80-308 Gda\u0144sk, Poland"}]},{"given":"S.","family":"Denifl","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Ionenphysik und Angewandte Physik and Center for Molecular Biosciences (CMBI), Leopold\u2013Franzens Universit\u00e4t Innsbruck 1 , Technikerstra\u00dfe 25\/3, 6020 Innsbruck, Austria"}]}],"member":"317","published-online":{"date-parts":[[2018,10,29]]},"reference":[{"key":"2023062521324932300_c1","doi-asserted-by":"publisher","first-page":"442","DOI":"10.2174\/156652409788167087","volume":"9","year":"2009","journal-title":"Curr. 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