{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T19:28:24Z","timestamp":1766086104012},"reference-count":30,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2000,4,1]],"date-time":"2000-04-01T00:00:00Z","timestamp":954547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2000,4]]},"DOI":"10.1067\/mai.2000.104784","type":"journal-article","created":{"date-parts":[[2003,10,17]],"date-time":"2003-10-17T17:01:17Z","timestamp":1066410077000},"page":"699-703","source":"Crossref","is-referenced-by-count":27,"title":["Inhaled budesonide for the treatment of acute wheezing and dyspnea in children up to 24 months old receiving intravenous hydrocortisone"],"prefix":"10.1067","volume":"105","author":[{"given":"Fl\u00e1vio","family":"Sano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geny K.","family":"Cortez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirceu","family":"Sol\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles K.","family":"Naspitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1067\/mai.2000.104784_bib1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1056\/NEJM199501193320301","article-title":"Asthma and wheezing in the first six years of life","volume":"332","author":"Martinez","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1067\/mai.2000.104784_bib2","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1183\/09031936.97.10081767","article-title":"Increased spontaneous release of tumor necrosis factor-\u03b1 by alveolar macrophages from wheezy infants","volume":"10","author":"Azevedo","year":"1997","journal-title":"Eur Respir J"},{"key":"10.1067\/mai.2000.104784_bib3","first-page":"346","article-title":"Eosinophil cationic protein in bronchoalveolar lavage from wheezy infants","volume":"7","author":"Azevedo","year":"1997","journal-title":"J Invest Allergol Clin Immunol"},{"key":"10.1067\/mai.2000.104784_bib4","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1136\/adc.68.3.356","article-title":"Treatment of severe steroid dependent preschool asthma with nebulized budesonide suspension","volume":"68","author":"Ilangovan","year":"1993","journal-title":"Arch Dis Child"},{"key":"10.1067\/mai.2000.104784_bib5","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1651-2227.1996.tb13989.x","article-title":"Nebulized budesonide for the treatment of moderate to severe asthma in infants and toddlers","volume":"85","author":"Wennergan","year":"1996","journal-title":"Acta Paediatr"},{"key":"10.1067\/mai.2000.104784_bib6","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0091-6749(96)70221-X","article-title":"Efficacy of nebulized budesonide in treatment of severe infantile asthma: a double-blind study","volume":"98","author":"De Blic","year":"1996","journal-title":"J Allergy Clin Immunol"},{"key":"10.1067\/mai.2000.104784_bib7","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1002\/(SICI)1099-0496(199605)21:5<310::AID-PPUL6>3.0.CO;2-Q","article-title":"Nebulized flunisolide in infants and young children with asthma: a pilot study","volume":"21","author":"Benedictis","year":"1996","journal-title":"Pediatr Pulmonol"},{"issue":"Suppl","key":"10.1067\/mai.2000.104784_bib8","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1203\/00006450-199407000-00301","article-title":"Effectiveness of nebulized adrenaline plus intramuscular dexamethasone, versus nebulized adrenaline plus budesonide in the management of croup [abstract]","volume":"36","author":"Tsanakas","year":"1994","journal-title":"Pediatr Res"},{"issue":"Suppl","key":"10.1067\/mai.2000.104784_bib9","first-page":"A214","article-title":"The treatment of outpatients with croup: comparison of nebulized budesonide, intramuscular dexamethasone, and placebo [abstract]","volume":"3","author":"Johnson","year":"1997","journal-title":"Am J Child Health"},{"key":"10.1067\/mai.2000.104784_bib10","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1136\/adc.76.2.155","article-title":"Double blind placebo controlled trial of nebulized budesonide for croup","volume":"76","author":"Godden","year":"1997","journal-title":"Arch Dis Child"},{"issue":"Suppl","key":"10.1067\/mai.2000.104784_bib11","first-page":"4705","article-title":"Comparison of prednisolone and nebulized budesonide in acute asthma in children: a pilot study [abstract]","volume":"19","author":"Curtis","year":"1995","journal-title":"Eur Respir J"},{"issue":"19 Suppl","key":"10.1067\/mai.2000.104784_bib12","first-page":"490s","article-title":"Comparison of nebulized budesonide with oral prednisolone in the treatment of severe acute asthma [abstract]","volume":"8","author":"Mitchell","year":"1995","journal-title":"Eur Respir J"},{"key":"10.1067\/mai.2000.104784_bib13","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/S0091-6749(98)70405-1","article-title":"Rapid induction of clinical response with a short-term high-dose starting schedule of budesonide nebulizing suspension in young children with recurrent wheezing episodes","volume":"101","author":"Volovitz","year":"1998","journal-title":"J Allergy Clin Immunol"},{"key":"10.1067\/mai.2000.104784_bib14","first-page":"113","article-title":"An uncontrolled assessment of nebulized budesonide in the treatment of acute infantile bronchiolitis","volume":"6","author":"Goodwin","year":"1995","journal-title":"Br J Clin Res"},{"key":"10.1067\/mai.2000.104784_bib15","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/S0091-6749(98)70019-3","article-title":"Efficacy and safety of budesonide inhalation suspension (Pulmicort Respules) in young children with inhaled steroid\u2013dependent, persistent asthma","volume":"102","author":"Shapiro","year":"1998","journal-title":"J Allergy Clin Immunol"},{"key":"10.1067\/mai.2000.104784_bib16","series-title":"Practical guide for the diagnosis and management of asthma. Based on the Expert Panel Report 2: Guidelines for the diagnosis and management of asthma","year":"1997"},{"key":"10.1067\/mai.2000.104784_bib17","first-page":"122","article-title":"The response of beta-2 agonists in children under the age of 2 years with acute asthma","volume":"65","author":"Bentur","year":"1990","journal-title":"Ann Allergy"},{"key":"10.1067\/mai.2000.104784_bib18","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1164\/ajrccm\/144.2.347","article-title":"Short-term effect of albuterol delivered via a new auxiliary device in wheezy infants","volume":"144","author":"Kraemer","year":"1991","journal-title":"Am Rev Respir Dis"},{"key":"10.1067\/mai.2000.104784_bib19","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1542\/peds.89.1.133","article-title":"Controlled trial of nebulized albuterol in children younger than 2 years of age with acute asthma","volume":"89","author":"Bentur","year":"1992","journal-title":"Pediatrics"},{"key":"10.1067\/mai.2000.104784_bib20","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1136\/adc.56.9.729","article-title":"Bronchodilator effect of inhaled ipratropium bromide in wheezy toddlers","volume":"56","author":"Hodges","year":"1981","journal-title":"Arch Dis Child"},{"issue":"1A Suppl","key":"10.1067\/mai.2000.104784_bib21","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0002-9343(96)80085-4","article-title":"Use of anticholinergic bronchodilator in children","volume":"100","author":"Rubin","year":"1996","journal-title":"Am J Med"},{"key":"10.1067\/mai.2000.104784_bib22","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3109\/02770909209048939","article-title":"Treatment of acute wheezing and dyspnea attacks in children under 2 years old: inhalation of fenoterol plus ipratropium bromide versus fenoterol","volume":"29","author":"Naspitz","year":"1992","journal-title":"J Asthma"},{"key":"10.1067\/mai.2000.104784_bib23","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1136\/bmj.317.7164.971","article-title":"Should inhaled anticholinergics be added to beta 2 agonists for treating acute childhood and adolescent asthma? A systematic review","volume":"317","author":"Plotnick","year":"1998","journal-title":"BMJ"},{"key":"10.1067\/mai.2000.104784_bib24","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1056\/NEJM199810083391503","article-title":"Effect of nebulized ipratropium on the hospitalization rates of children with asthma","volume":"339","author":"Qureshi","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1067\/mai.2000.104784_bib25","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0022-3476(98)70054-X","article-title":"Randomized controlled trial of ipratropium bromide and frequent low doses of salbutamol in the management of mild and moderate acute pediatric asthma","volume":"133","author":"Ducharme","year":"1998","journal-title":"J Pediatr"},{"key":"10.1067\/mai.2000.104784_bib26","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S0091-6749(98)70276-3","article-title":"Effectiveness and safety of inhaled corticosteroids in controlling acute asthma attacks in children who were treated in the emergency department: a controlled comparative study with oral prednisolone","volume":"102","author":"Volovitz","year":"1998","journal-title":"J Allergy Clin Immunol"},{"key":"10.1067\/mai.2000.104784_bib27","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0009-9236(96)90216-7","article-title":"A comparison of nebulized budesonide with oral prednisolone in treatment of exacerbation of obstructive pulmonary disease","volume":"60","author":"Morice","year":"1996","journal-title":"Clin Pharmacol Ther"},{"key":"10.1067\/mai.2000.104784_bib28","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1164\/ajrccm.157.3.157315","article-title":"Efficacy and safety of inhaled corticosteroids","volume":"157","author":"Barnes","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1067\/mai.2000.104784_bib29","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1001\/archpedi.1996.02170300066013","article-title":"Anti-inflammatory therapy reduces wheezing after bronchiolitis","volume":"150","author":"Reijonen","year":"1996","journal-title":"Arch Pediatr Adolesc Med"},{"key":"10.1067\/mai.2000.104784_bib30","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0022-3476(98)70316-6","article-title":"Early nebulized budesonide in the treatment of bronchiolitis and the prevention of postbronchiolitic wheezing","volume":"132","author":"Richter","year":"1998","journal-title":"J Pediatr"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674900579585?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674900579585?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T05:42:28Z","timestamp":1682574148000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674900579585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,4]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2000,4]]}},"alternative-id":["S0091674900579585"],"URL":"https:\/\/doi.org\/10.1067\/mai.2000.104784","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2000,4]]}}}