{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:17:46Z","timestamp":1791310666827,"version":"4.3.1"},"reference-count":33,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2000,7,1]],"date-time":"2000-07-01T00:00:00Z","timestamp":962409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2000,7]]},"DOI":"10.1067\/mai.2000.107194","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T04:15:48Z","timestamp":1027570548000},"page":"159-166","source":"Crossref","is-referenced-by-count":166,"special_numbering":"P1","title":["Persimmon leaf extract and astragalin inhibit development of dermatitis and IgE elevation in NC\/Nga mice"],"prefix":"10.1067","volume":"106","author":[{"given":"Mayumi","family":"Kotani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motonobu","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihito","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Higa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Way","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Suemura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadamitsu","family":"Kishimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1067\/mai.2000.107194_bib1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0091-6749(99)70536-1","article-title":"Worldwide variations in the prevalence of symptoms of atopic eczema in the international study of asthma and allergies in childhood","volume":"103","author":"Williams","year":"1999","journal-title":"J Allergy Clin Immunol"},{"key":"10.1067\/mai.2000.107194_bib2","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/1523-1747.ep12371746","article-title":"Atopic dermatitis: recent trends in pathogenesis and therapy","volume":"102","author":"Cooper","year":"1994","journal-title":"J Invest Dermatol"},{"key":"10.1067\/mai.2000.107194_bib3","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0167-5699(98)01285-7","article-title":"A role for Th1 and Th2 cells in immunopathogenesis of atopic dermatitis","volume":"19","author":"Grewe","year":"1998","journal-title":"Immunol Today"},{"key":"10.1067\/mai.2000.107194_bib4","first-page":"25","article-title":"Atopic dermatitis: immunobiology and treatment with immune modulators","volume":"107","author":"Leung","year":"1997","journal-title":"Clin Exp Immunol"},{"key":"10.1067\/mai.2000.107194_bib5","first-page":"3","article-title":"Therapeutics in atopic dermatitis","volume":"13","author":"Graham-Brown","year":"1997","journal-title":"Adv Dermatol"},{"key":"10.1067\/mai.2000.107194_bib6","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/265635a0","article-title":"Effect of flavone inhibitors of transport ATPases on histamine secretion from rat mast cells","volume":"265","author":"Fewtrell","year":"1977","journal-title":"Nature"},{"key":"10.1067\/mai.2000.107194_bib7","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.1600-0773.1980.tb01564.x","article-title":"The role of plasma membrane Ca++-Mg++ activated adenosine triphosphatase of rat mast cells on histamine release","volume":"47","author":"Chakravarty","year":"1980","journal-title":"Acta Pharmacol Toxicol"},{"key":"10.1067\/mai.2000.107194_bib8","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1055\/s-2007-969381","article-title":"Inhibition of mast cell histamine release by flavonoids and biflavonoids","volume":"1","author":"Amellal","year":"1985","journal-title":"Planta Med"},{"key":"10.1067\/mai.2000.107194_bib9","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1007\/BF02974647","article-title":"Studies of structure activity relationship of flavonoids for the anti-allergic actions","volume":"21","author":"Cheong","year":"1998","journal-title":"Arch Pharm Res"},{"key":"10.1067\/mai.2000.107194_bib10","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0006-2952(86)90520-4","article-title":"Flavonoid impairment of neutrophil response","volume":"35","author":"Pagonis","year":"1986","journal-title":"Biochem Pharmacol"},{"key":"10.1067\/mai.2000.107194_bib11","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1248\/cpb.27.2865","article-title":"Hypotensive principle of Diospyros khaki leaves","volume":"27","author":"Funayama","year":"1979","journal-title":"Chem Pharm Bull"},{"key":"10.1067\/mai.2000.107194_bib12","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1021\/np50052a017","article-title":"Inhibitory effects of various flavonoids isolated from leaves of persimmon on angiotensin-converting enzyme activity","volume":"50","author":"Kameda","year":"1987","journal-title":"J Nat Prod"},{"key":"10.1067\/mai.2000.107194_bib13","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/(SICI)1099-1573(199708)11:5<343::AID-PTR103>3.0.CO;2-4","article-title":"Antipruritic effect of flavonol and 1,4-naphthoquinone derivatives from Impatiens balsamina L","volume":"11","author":"Ishiguro","year":"1997","journal-title":"Phytother Res"},{"key":"10.1067\/mai.2000.107194_bib14","doi-asserted-by":"crossref","first-page":"147","DOI":"10.4327\/jsnfs.52.147","article-title":"Inhibitory effects of persimmon leaf extract on allergic reaction in human basophilic leukemia cells and mice","volume":"52","author":"Kotani","year":"1999","journal-title":"J Jpn Soc Nutr Food Sci"},{"key":"10.1067\/mai.2000.107194_bib15","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/367183a0","article-title":"High-affinity IgE receptor on eosinophils is involved in defense against parasites","volume":"367","author":"Gounni","year":"1994","journal-title":"Nature"},{"key":"10.1067\/mai.2000.107194_bib16","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/0145-2126(85)90060-8","article-title":"A new leukemia cell line with Philadelphia chromosome characterized as basophil precursors","volume":"9","author":"Kishi","year":"1985","journal-title":"Leuk Res"},{"key":"10.1067\/mai.2000.107194_bib17","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1159\/000233523","article-title":"Mouse ear PCA as a model for evaluating antianaphylactic agents","volume":"74","author":"Inagaki","year":"1984","journal-title":"Int Arch Allergy Appl Immunol"},{"key":"10.1067\/mai.2000.107194_bib18","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1093\/intimm\/9.3.461","article-title":"Development of atopic dermatitis-like skin lesion with IgE hyperproduction in NC\/Nga mice","volume":"9","author":"Matsuda","year":"1997","journal-title":"Int Immunol"},{"key":"10.1067\/mai.2000.107194_bib19","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.4049\/jimmunol.162.2.1056","article-title":"IgE hyperproduction through enhanced tyrosine phosphorylation of Janus kinase 3 in NC\/Nga mice, a model for human atopic dermatitis","volume":"162","author":"Matsumoto","year":"1999","journal-title":"J Immunol"},{"key":"10.1067\/mai.2000.107194_bib20","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/0006-2952(92)90489-6","article-title":"Effects of flavonoids on immune and inflammatory cell functions","volume":"43","author":"Middleton","year":"1992","journal-title":"Biochem Parmacol"},{"key":"10.1067\/mai.2000.107194_bib21","doi-asserted-by":"crossref","first-page":"5079","DOI":"10.1248\/cpb.33.5079","article-title":"Inhibitory effects of tannins on hyaluronidase activation and on the degranulation from rat mensentery mast cells","volume":"33","author":"Kakegawa","year":"1985","journal-title":"Chem Pharm Bull"},{"key":"10.1067\/mai.2000.107194_bib22","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/j.1398-9995.1997.tb02546.x","article-title":"Effect of tea polyphenols on histamine release from rat basophilic leukemia (RBL-2H3) cells: the structure-inhibitory activity relationship","volume":"52","author":"Matsuo","year":"1997","journal-title":"Allergy"},{"key":"10.1067\/mai.2000.107194_bib23","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1055\/s-2007-971549","article-title":"Inhibition of passive cutaneous anaphylaxis by compounds of Camellia sinensis","volume":"42","author":"Kar","year":"1981","journal-title":"Planta Medica"},{"key":"10.1067\/mai.2000.107194_bib24","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1248\/bpb.18.683","article-title":"Antiallergic constituents from oolong tea stem","volume":"18","author":"Ohmori","year":"1995","journal-title":"Biol Pharm Bull"},{"key":"10.1067\/mai.2000.107194_bib25","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/0091-6749(84)90446-9","article-title":"Mast cells and the actions of flavonoids","volume":"73","author":"Foreman","year":"1984","journal-title":"J Allergy Clin Immunol"},{"key":"10.1067\/mai.2000.107194_bib26","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.4049\/jimmunol.136.7.2348","article-title":"Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins","volume":"136","author":"Mosmann","year":"1986","journal-title":"J Immunol"},{"key":"10.1067\/mai.2000.107194_bib27","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0092-8674(94)90332-8","article-title":"Lymphokine responses and cytokines","volume":"76","author":"Paul","year":"1994","journal-title":"Cell"},{"key":"10.1067\/mai.2000.107194_bib28","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1146\/annurev.iy.12.040194.001303","article-title":"Lymphokine production by human T cells in disease states","volume":"12","author":"Romagnani","year":"1994","journal-title":"Annu Rev Immunol"},{"key":"10.1067\/mai.2000.107194_bib29","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1146\/annurev.iy.12.040194.003223","article-title":"Acquisition of lymphokine-producing phenotype by CD4+ T cells","volume":"12","author":"Seder","year":"1994","journal-title":"Annu Rev Immunol"},{"key":"10.1067\/mai.2000.107194_bib30","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1084\/jem.179.4.1285","article-title":"CD4+NK1.1+T cells promptly produce interleukin-4 in response to in vitro challenge with anti-CD3","volume":"179","author":"Yoshimoto","year":"1994","journal-title":"J Exp Med"},{"key":"10.1067\/mai.2000.107194_bib31","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1159\/000237375","article-title":"Peripheral blood T lymphocytes and basophils, freshly isolated from house dust mite sensitive patients, produce interleukin-4 in response to allergen-specific stimulation","volume":"111","author":"Ochi","year":"1996","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1067\/mai.2000.107194_bib32","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1084\/jem.176.5.1381","article-title":"Interleukin 4 is localized to and released by human mast cells","volume":"176","author":"Bradding","year":"1992","journal-title":"J Exp Med"},{"key":"10.1067\/mai.2000.107194_bib33","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1111\/j.1365-2133.1994.tb08522.x","article-title":"Mast cells are one major source of interleukin-4 in atopic dermatitis","volume":"131","author":"Horsmanheimo","year":"1994","journal-title":"Br J Dermatol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674900909515?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674900909515?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T14:37:33Z","timestamp":1680532653000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674900909515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,7]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,7]]}},"alternative-id":["S0091674900909515"],"URL":"https:\/\/doi.org\/10.1067\/mai.2000.107194","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2000,7]]}}}