{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:20:58Z","timestamp":1791073258009,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2000,10,1]],"date-time":"2000-10-01T00:00:00Z","timestamp":970358400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2000,10]]},"DOI":"10.1067\/mai.2000.109823","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T04:17:08Z","timestamp":1027570628000},"page":"705-712","source":"Crossref","is-referenced-by-count":66,"title":["Relation of epidermal growth factor receptor expression to goblet cell hyperplasia in nasal polyps"],"prefix":"10.1067","volume":"106","author":[{"given":"Pierre-Regis","family":"Burgel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estelle","family":"Escudier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Coste","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trang","family":"Dao-Pick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris F.","family":"Ueki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Takeyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Jeong","family":"Shim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew H.","family":"Murr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay A.","family":"Nadel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1067\/mai.2000.109823_bib1","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1136\/bmj.311.7017.1411","article-title":"Diagnosis and treatment of nasal polyps","volume":"311","author":"Lund","year":"1995","journal-title":"BMJ"},{"key":"10.1067\/mai.2000.109823_bib2","first-page":"435","article-title":"Histochemical analysis of nasal polyps","volume":"103","author":"Krajina","year":"1987","journal-title":"Acta Otolaryngol (Stockh)"},{"key":"10.1067\/mai.2000.109823_bib3","doi-asserted-by":"crossref","first-page":"755","DOI":"10.3109\/00016489609137920","article-title":"Nasal polyposis pathogenesis: a flow cytometric and immunohistochemical study of epithelial proliferation","volume":"116","author":"Coste","year":"1996","journal-title":"Acta Otolaryngol (Stockh)"},{"key":"10.1067\/mai.2000.109823_bib4","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1165\/ajrcmb.15.4.8879177","article-title":"Eosinophil infiltration in nonallergic chronic hyperplastic sinusitis with nasal polyposis (CHS\/NP) is associated with endothelial VCAM-1 upregulation and expression of TNF-alpha","volume":"15","author":"Hamilos","year":"1996","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1067\/mai.2000.109823_bib5","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.1073\/pnas.96.6.3081","article-title":"Epidermal growth factor system regulates mucin production in airways","volume":"96","author":"Takeyama","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1067\/mai.2000.109823_bib6","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1164\/ajrccm.157.6.9709113","article-title":"Platelet-activating factor induces goblet cell hyperplasia and mucin gene expression in airways","volume":"157","author":"Lou","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1067\/mai.2000.109823_bib7","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1046\/j.1365-2222.1998.00380.x","article-title":"GM-CSF, IL-5 and RANTES immunoreactivity and mRNA expression in chronic hyperplastic sinusitis with nasal polyposis","volume":"28","author":"Hamilos","year":"1998","journal-title":"Clin Exp Allergy"},{"key":"10.1067\/mai.2000.109823_bib8","first-page":"191","article-title":"Decreased expression of the CFTR protein in remodeled human nasal epithelium from non-cystic fibrosis patients","volume":"72","author":"Brezillon","year":"1995","journal-title":"Lab Invest"},{"key":"10.1067\/mai.2000.109823_bib9","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.4049\/jimmunol.153.5.2278","article-title":"TNF-alpha production by eosinophils in upper airways inflammation (nasal polyposis)","volume":"153","author":"Finotto","year":"1994","journal-title":"J Immunol"},{"key":"10.1067\/mai.2000.109823_bib10","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1002\/eji.1830220327","article-title":"The glycosylphosphatidylinositol-linked Fc gamma receptor III represents the dominant receptor structure for immune complex activation of neutrophils","volume":"22","author":"Hundt","year":"1992","journal-title":"Eur J Immunol"},{"key":"10.1067\/mai.2000.109823_bib11","first-page":"347","article-title":"Nasal polyps: a comparative study of morphologic and etiopathogenic aspects","volume":"21","author":"Paludetti","year":"1983","journal-title":"Rhinology"},{"key":"10.1067\/mai.2000.109823_bib12","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3109\/00016488709134709","article-title":"A histological study of formation and growth of nasal polyps","volume":"103","author":"Kakoi","year":"1987","journal-title":"Acta Otolaryngol (Stockh)"},{"key":"10.1067\/mai.2000.109823_bib13","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1165\/ajrcmb.11.6.7946402","article-title":"Quantitation of mucin mRNA in respiratory and intestinal epithelial cells","volume":"11","author":"Voynow","year":"1994","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1067\/mai.2000.109823_bib14","doi-asserted-by":"crossref","first-page":"293","DOI":"10.2500\/105065897781446685","article-title":"Mucin mRNA expression in normal and vasomotor inferior turbinates","volume":"11","author":"Aust","year":"1997","journal-title":"Am J Rhinol"},{"key":"10.1067\/mai.2000.109823_bib15","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1073\/pnas.90.3.863","article-title":"Tumor necrosis factor-alpha induces the expression of transforming growth factor-alpha and the epidermal growth factor receptor in human pancreatic cells","volume":"90","author":"Schmiegel","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1067\/mai.2000.109823_bib16","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/0091-6749(93)90267-J","article-title":"Eosinophils in nasal polyps and nasal mucosa: An immuno-histochemical study","volume":"91","author":"Stoop","year":"1993","journal-title":"J Allergy Clin Immunol"},{"key":"10.1067\/mai.2000.109823_bib17","first-page":"1009","article-title":"Polymorphonuclear leukocytes as a significant source of tumor necrosis factor-alpha in endotoxin-challenged lung tissue","volume":"143","author":"Xing","year":"1993","journal-title":"Am J Pathol"},{"key":"10.1067\/mai.2000.109823_bib18","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1165\/ajrcmb\/7.4.385","article-title":"Human lung mast cells and pulmonary macrophages produce tumor necrosis-alpha in sensitized lung tissue after IgE receptor triggering","volume":"7","author":"Ohkawara","year":"1992","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1067\/mai.2000.109823_bib19","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S1357-2725(99)00015-1","article-title":"EGF receptor","volume":"31","author":"Wells","year":"1999","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1067\/mai.2000.109823_bib20","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/0091-6749(94)90379-4","article-title":"Expression of transforming growth factors-alpha and beta-1 messenger RNA and product by eosinophils in nasal polyps","volume":"93","author":"Elovic","year":"1994","journal-title":"J Allergy Clin Immunol"},{"key":"10.1067\/mai.2000.109823_bib21","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/379557a0","article-title":"Role of Transactivation of the EGF receptor in signaling by G-protein-coupled receptors","volume":"379","author":"Daub","year":"1996","journal-title":"Nature"},{"key":"10.1067\/mai.2000.109823_bib22","doi-asserted-by":"crossref","first-page":"3895","DOI":"10.1182\/blood.V84.11.3895.bloodjournal84113895","article-title":"Activation of phospholipase D by interleukin-8 in human neutrophils","volume":"84","author":"Sozzani","year":"1994","journal-title":"Blood"},{"key":"10.1067\/mai.2000.109823_bib23","doi-asserted-by":"crossref","first-page":"4615","DOI":"10.4049\/jimmunol.157.10.4615","article-title":"Mechanisms of stimulation of the respiratory burst by TNF in nonadherent neutrophils: its independence of lipidic transmembrane signaling and dependence on protein tyrosine phosphorylation and cytoskeleton","volume":"157","author":"Dusi","year":"1996","journal-title":"J Immunol"},{"key":"10.1067\/mai.2000.109823_bib24","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1165\/ajrcmb.19.5.3249","article-title":"EGF-Receptor phosphorylation and signaling are targeted by H2O2 redox stress","volume":"19","author":"Goldkorn","year":"1998","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1067\/mai.2000.109823_bib25","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.4049\/jimmunol.164.3.1546","article-title":"Oxidative stress causes mucin synthesis via transactivation of epidermal growth factor receptor: Role of neutrophils","volume":"164","author":"Takeyama","year":"2000","journal-title":"J Immunol"},{"key":"10.1067\/mai.2000.109823_bib26","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1083\/jcb.133.1.211","article-title":"UV activates growth factor receptors via reactive oxygen intermediates","volume":"133","author":"Huang","year":"1996","journal-title":"J Cell Biol"},{"key":"10.1067\/mai.2000.109823_bib27","first-page":"L294","article-title":"Neutrophil-dependent goblet cell degranulation: role of membrane-bound elastase and adhesion molecules","volume":"275","author":"Takeyama","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1067\/mai.2000.109823_bib28","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1165\/ajrcmb.11.5.7524566","article-title":"Expression of transforming growth factor-alpha and epidermal growth factor receptor is increased following Bleomycin-induced lung injury in rats","volume":"11","author":"Madtes","year":"1994","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1067\/mai.2000.109823_bib29","first-page":"A320","article-title":"Regranulation of goblet cells is mediated by epidermal growth factor receptor (EGFR) system in nasal epithelium of rats [Abstract]","volume":"161","author":"Lee","year":"2000","journal-title":"Am J Respir Crit Care Med"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674900630518?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674900630518?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T14:54:33Z","timestamp":1680533673000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674900630518"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,10]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2000,10]]}},"alternative-id":["S0091674900630518"],"URL":"https:\/\/doi.org\/10.1067\/mai.2000.109823","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2000,10]]}}}