{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:57:52Z","timestamp":1790506672507,"version":"4.1.0"},"reference-count":63,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2000,11,1]],"date-time":"2000-11-01T00:00:00Z","timestamp":973036800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2000,11]]},"DOI":"10.1067\/mai.2000.110153","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T04:17:12Z","timestamp":1027570632000},"page":"S213-S220","source":"Crossref","is-referenced-by-count":85,"special_numbering":"S","title":["Neural integration and allergic disease"],"prefix":"10.1067","volume":"106","author":[{"given":"Bradley J.","family":"Undem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radhika","family":"Kajekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn D.","family":"Hunter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen C.","family":"Myers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1067\/mai.2000.110153_bib1","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/S0091-6749(97)70167-2","article-title":"Dose-dependent effects of capsaicin nasal challenge: In vivo evidence of human airway neurogenic inflammation","volume":"100","author":"Sanico","year":"1997","journal-title":"J Allergy Clin Immunol"},{"key":"10.1067\/mai.2000.110153_bib2","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1159\/000236628","article-title":"Perennial rhinitis subjects have altered vascular, glandular, and neural responses to bradykinin nasal provocation","volume":"103","author":"Baraniuk","year":"1994","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1067\/mai.2000.110153_bib3","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1111\/j.1476-5381.1970.tb09898.x","article-title":"Role of the vagus nerves in anaphylaxis and histamine-induced bronchoconstrictions in guinea-pigs","volume":"39","author":"Mills","year":"1970","journal-title":"Br J Pharmacol"},{"key":"10.1067\/mai.2000.110153_bib4","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0034-5687(97)00030-3","article-title":"Sensory receptor activation by mediators of defense reflexes in guinea-pig lungs","volume":"108","author":"Bergren","year":"1997","journal-title":"Respir Physiol"},{"key":"10.1067\/mai.2000.110153_bib5","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1113\/jphysiol.1996.sp021234","article-title":"Immunomodulation of afferent neurons in guinea-pig isolated airway","volume":"491","author":"Riccio","year":"1996","journal-title":"J Physiol (Lond)"},{"key":"10.1067\/mai.2000.110153_bib6","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/BF01260988","article-title":"Neurogenic inflammation in the rat trachea: I. Changes in venules, leucocytes and epithelial cells","volume":"17","author":"McDonald","year":"1988","journal-title":"J Neurocytol"},{"key":"10.1067\/mai.2000.110153_bib7","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1006\/clin.1997.4446","article-title":"Substance P: A regulatory neuropeptide for hematopoiesis and immune functions","volume":"85","author":"Rameshwar","year":"1997","journal-title":"Clin Immunol Immunopathol"},{"key":"10.1067\/mai.2000.110153_bib8","first-page":"646","article-title":"Antigen-induced enhancement of noncholinergic contractile responses to vagus nerve and electrical field stimulation in guinea pig isolated trachea","volume":"262","author":"Ellis","year":"1992","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1067\/mai.2000.110153_bib9","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1152\/jappl.1998.84.2.537","article-title":"Plasma extravasation through neuronal stimulation in human nasal mucosa in the setting of allergic rhinitis","volume":"84","author":"Sanico","year":"1998","journal-title":"J Appl Physiol"},{"key":"10.1067\/mai.2000.110153_bib10","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1172\/JCI117280","article-title":"Effects of chronic airway inflammation on the activity and enzymatic inactivation of neuropeptides in guinea pig lungs","volume":"93","author":"Lilly","year":"1994","journal-title":"J Clin Invest"},{"key":"10.1067\/mai.2000.110153_bib11","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1159\/000024053","article-title":"Allergen-induced sensory neuroplasticity in airways","volume":"118","author":"Undem","year":"1999","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1067\/mai.2000.110153_bib12","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1164\/ajrccm.161.6.9908051","article-title":"Nerve growth factor-induced phenotypic switch in tachykinergic neurons innervating airways","volume":"161","author":"Hunter","year":"2000","journal-title":"Am J Respir Crit Care Med."},{"key":"10.1067\/mai.2000.110153_bib13","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1152\/jappl.1991.71.3.970","article-title":"Influence of antigen on membrane properties of guinea pig bronchial ganglion neurons","volume":"71","author":"Myers","year":"1991","journal-title":"J Appl Physiol"},{"key":"10.1067\/mai.2000.110153_bib14","first-page":"L879","article-title":"Antigen depolarizes guinea pig bronchial parasympathetic ganglion neurons by activation of histamine H1 receptors","volume":"268","author":"Myers","year":"1995","journal-title":"Am J Physiol"},{"key":"10.1067\/mai.2000.110153_bib15","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1159\/000236976","article-title":"Neurophysiology of mast cell-nerve interactions in the airways","volume":"107","author":"Undem","year":"1995","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1067\/mai.2000.110153_bib16","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1172\/JCI112984","article-title":"Immunological regulation of synaptic transmission in isolated guinea pig autonomic ganglia","volume":"79","author":"Weinreich","year":"1987","journal-title":"J Clin Invest"},{"key":"10.1067\/mai.2000.110153_bib17","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1113\/jphysiol.1989.sp017498","article-title":"Endogenous histamine excites neurones in the guinea-pig superior cervical ganglion in vitro","volume":"409","author":"Christian","year":"1989","journal-title":"J Physiol (Lond)"},{"key":"10.1067\/mai.2000.110153_bib18","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1152\/jn.1995.73.5.2004","article-title":"Antigen-induced long-term potentiation of nicotinic synaptic transmission in the superior cervical ganglion of the guinea pig","volume":"73","author":"Weinreich","year":"1995","journal-title":"J Neurophysiol"},{"key":"10.1067\/mai.2000.110153_bib19","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1152\/jappl.1991.71.6.2255","article-title":"Dysfunction of M2-muscarinic receptors in pulmonary parasympathetic nerves after antigen challenge","volume":"71","author":"Fryer","year":"1991","journal-title":"J Appl Physiol"},{"key":"10.1067\/mai.2000.110153_bib20","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0014-2999(96)00820-5","article-title":"Dysfunctional muscarinic M2 autoreceptors in vagally induced bronchoconstriction of conscious guinea pigs after the early allergic reaction","volume":"318","author":"Ten Berge","year":"1996","journal-title":"Eur J Pharmacol"},{"key":"10.1067\/mai.2000.110153_bib21","doi-asserted-by":"crossref","first-page":"S154","DOI":"10.1164\/ajrccm.158.supplement_2.13tac120","article-title":"Muscarinic receptors and control of airway smooth muscle","volume":"158","author":"Fryer","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1067\/mai.2000.110153_bib22","first-page":"L522","article-title":"Mediators of anaphylaxis but not activated neutrophils augment cholinergic responses of equine small airways","volume":"276","author":"Olszewski","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1067\/mai.2000.110153_bib23","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1152\/physrev.1992.72.3.699","article-title":"Modulation of neurotransmission in airways","volume":"72","author":"Barnes","year":"1992","journal-title":"Physiol Rev"},{"key":"10.1067\/mai.2000.110153_bib24","first-page":"G151","article-title":"Integrative immunophysiology in the intestinal mucosa","volume":"267","author":"Perdue","year":"1994","journal-title":"Am J Physiol"},{"key":"10.1067\/mai.2000.110153_bib25","first-page":"G617","article-title":"Intestinal permeability in allergic rats: Nerve involvement in antigen-induced changes","volume":"264","author":"Crowe","year":"1993","journal-title":"Am J Physiol"},{"key":"10.1067\/mai.2000.110153_bib26","first-page":"G181","article-title":"Intestinal anaphylaxis induces Fos immunoreactivity in myenteric plexus of rat small intestine","volume":"272","author":"Miampamba","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1067\/mai.2000.110153_bib27","first-page":"G812","article-title":"Anaphylaxis-induced alterations in intestinal motility: Role of extrinsic neural pathways","volume":"275","author":"Scott","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1067\/mai.2000.110153_bib28","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/S0091-6749(96)70193-8","article-title":"Evidence that enhanced nasal reactivity to bradykinin in symptomatic allergic individuals is mediated by neural reflexes","volume":"97","author":"Riccio","year":"1996","journal-title":"J Allergy Clin Invest"},{"key":"10.1067\/mai.2000.110153_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0163-7258(89)90021-1","article-title":"Afferent pathways involved in reflex regulation of airway smooth muscle","volume":"42","author":"Coleridge","year":"1989","journal-title":"Pharmacol Ther"},{"key":"10.1067\/mai.2000.110153_bib30","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1113\/jphysiol.1993.sp019802","article-title":"An in vitro study of the properties of single vagal afferents innervating guinea-pig airways","volume":"469","author":"Fox","year":"1993","journal-title":"J Physiol (Lond)"},{"key":"10.1067\/mai.2000.110153_bib31","first-page":"682","article-title":"Characterization of vagal afferent subtypes stimulated by bradykinin in guinea pig trachea","volume":"289","author":"Kajekar","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1067\/mai.2000.110153_bib32","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0165-1838(93)90375-5","article-title":"Electrophysiological properties and chemosensitivity of guinea pig nodose ganglion neurons in vitro","volume":"44","author":"Undem","year":"1993","journal-title":"J Auton Nerv Syst"},{"key":"10.1067\/mai.2000.110153_bib33","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0165-1838(93)90376-6","article-title":"Immunologically induced neuromodulation of guinea pig nodose ganglion neurons","volume":"44","author":"Undem","year":"1993","journal-title":"J Auton Nerv Syst"},{"key":"10.1067\/mai.2000.110153_bib34","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0034-5687(93)90070-Q","article-title":"Histamine enhances vagal pulmonary C-fiber responses to capsaicin and lung inflation","volume":"93","author":"Lee","year":"1993","journal-title":"Respir Physiol"},{"key":"10.1067\/mai.2000.110153_bib35","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/jidsymp.1997.15","article-title":"Neurogenic inflammation in skin and airways","volume":"2","author":"Baluk","year":"1997","journal-title":"J Investig Dermatol Symp Proc"},{"key":"10.1067\/mai.2000.110153_bib36","doi-asserted-by":"crossref","first-page":"3815","DOI":"10.1002\/(SICI)1521-4141(199912)29:12<3815::AID-IMMU3815>3.0.CO;2-#","article-title":"Endogenously produced substance P contributes to lymphocyte proliferation induced by dendritic cells and direct TCR ligation","volume":"29","author":"Lambrecht","year":"1999","journal-title":"Eur J Immunol"},{"key":"10.1067\/mai.2000.110153_bib37","first-page":"95","article-title":"Pharmacological examination of receptors mediating contractile responses to tachykinins in airways isolated from human, guinea pig and hamster","volume":"267","author":"Ellis","year":"1993","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1067\/mai.2000.110153_bib38","first-page":"319","article-title":"Pharmacological examination of the neurokinin-1 receptor mediating relaxation of human intralobar pulmonary artery","volume":"292","author":"Pedersen","year":"2000","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1067\/mai.2000.110153_bib39","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/sj.bjp.0701822","article-title":"Effects of tachykinin NK1 receptor antagonists on vagal hyperreactivity and neuronal M2 muscarinic receptor function in antigen challenged guinea-pigs","volume":"124","author":"Costello","year":"1998","journal-title":"Br J Pharmacol"},{"key":"10.1067\/mai.2000.110153_bib40","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1164\/ajrccm.159.2.9804125","article-title":"Involvement of tachykinin NK1 receptor in the development of allergen-induced airway hyperreactivity and airway inflammation in conscious, unrestrained guinea pigs","volume":"159","author":"Schuiling","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1067\/mai.2000.110153_bib41","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1398-9995.1987.tb02182.x","article-title":"Capsaicin-sensitive nerves and the cutaneous allergy reaction in man. Possible involvement of sensory neuropeptides in the flare reaction","volume":"42","author":"Lundblad","year":"1987","journal-title":"Allergy"},{"key":"10.1067\/mai.2000.110153_bib42","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1113\/jphysiol.1991.sp018561","article-title":"Role of peptidoleukotrienes in capsaicin-sensitive sensory fibre-mediated responses in guinea-pig airways","volume":"436","author":"Ellis","year":"1991","journal-title":"J Physiol (Lond)"},{"key":"10.1067\/mai.2000.110153_bib43","first-page":"602","article-title":"Inhibition of 5-lipoxygenase diminishes neurally evoked tachykinergic contraction of guinea pig isolated airway","volume":"285","author":"McAlexander","year":"1998","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1067\/mai.2000.110153_bib44","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1172\/JCI119039","article-title":"Induction of tachykinin gene and peptide expression in guinea pig nodose primary afferent neurons by allergic airway inflammation","volume":"98","author":"Fischer","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1067\/mai.2000.110153_bib45","doi-asserted-by":"crossref","first-page":"7683","DOI":"10.1523\/JNEUROSCI.17-20-07683.1997","article-title":"Allergic inflammation in isolated vagal sensory ganglia unmasks silent NK-2 tachykinin receptors","volume":"17","author":"Weinreich","year":"1997","journal-title":"J Neurosci"},{"key":"10.1067\/mai.2000.110153_bib46","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1164\/ajrccm.161.1.9903091","article-title":"Antigen inhalation unmasks NK-2 tachykinin receptor-mediated responses in vagal afferents","volume":"161","author":"Moore","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1067\/mai.2000.110153_bib47","first-page":"H1350","article-title":"A presynaptic mechanism contributes to depression of autonomic signal transmission in NTS","volume":"277","author":"Chen","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1067\/mai.2000.110153_bib48","first-page":"279","article-title":"Vagal reflexs","author":"Widdicombe","year":"1994"},{"key":"10.1067\/mai.2000.110153_bib49","first-page":"110","article-title":"On vagal bronchoconstriction in asthmatic patients by nasal irritation","volume":"128","author":"Nolte","year":"1983","journal-title":"Eur J Respir Dis Suppl"},{"key":"10.1067\/mai.2000.110153_bib50","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1113\/jphysiol.1996.sp021703","article-title":"Interganglionic segregation of distinct vagal afferent fibre phenotypes in guinea-pig airways","volume":"496","author":"Riccio","year":"1996","journal-title":"J Physiol (Lond)"},{"key":"10.1067\/mai.2000.110153_bib51","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/0166-2236(94)90018-3","article-title":"Modulation of spinal excitability: Co-operation between neurokinin and excitatory amino acid neurotransmitters","volume":"17","author":"Urban","year":"1994","journal-title":"Trends Neurosci"},{"key":"10.1067\/mai.2000.110153_bib52","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/384360a0","article-title":"Inflammatory pain hypersensitivity mediated by phenotypic switch in myelinated primary sensory neurons","volume":"384","author":"Neumann","year":"1996","journal-title":"Nature"},{"key":"10.1067\/mai.2000.110153_bib53","first-page":"87","article-title":"Autonomic ganglia","author":"Undem","year":"1997"},{"key":"10.1067\/mai.2000.110153_bib54","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0165-1838(90)90164-E","article-title":"Mast cells in the guinea pig superior cervical ganglion: A functional and histological assessment","volume":"30","author":"Undem","year":"1990","journal-title":"J Auton Nerv Syst"},{"key":"10.1067\/mai.2000.110153_bib55","doi-asserted-by":"crossref","first-page":"542","DOI":"10.3181\/00379727-200-43468","article-title":"Decentralization of the superior cervical ganglia and the immediate hypersensitivity response","volume":"200","author":"Mathison","year":"1992","journal-title":"Proc Soc Exp Biol Med"},{"key":"10.1067\/mai.2000.110153_bib56","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0167-0115(92)90662-E","article-title":"Ultrastructure of calcitonin gene-related peptide-immunoreactive nerve fibres in guinea-pig peribronchial ganglia","volume":"37","author":"Kummer","year":"1992","journal-title":"Regul Pept"},{"key":"10.1067\/mai.2000.110153_bib57","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S0165-1838(96)00081-1","article-title":"Anatomical and electrophysiological comparison of the sensory innervation of bronchial and tracheal parasympathetic ganglion neurons","volume":"61","author":"Myers","year":"1996","journal-title":"J Auton Nerv Syst"},{"key":"10.1067\/mai.2000.110153_bib58","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.2460\/ajvr.1994.55.08.1066","article-title":"Substance P and calcitonin gene-related peptide-like immunoreactive nerve fibers in lungs from adult equids","volume":"55","author":"Sonea","year":"1994","journal-title":"Am J Vet Res"},{"key":"10.1067\/mai.2000.110153_bib59","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1165\/ajrcmb.14.3.8845170","article-title":"Neurochemical characterization of intrinsic neurons in ferret tracheal plexus","volume":"14","author":"Dey","year":"1996","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1067\/mai.2000.110153_bib60","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1164\/ajrccm.154.1.8680682","article-title":"Nitric oxide synthase in neurons and nerve fibers of lower airways and in vagal sensory ganglia of man. Correlation with neuropeptides","volume":"154","author":"Fischer","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1067\/mai.2000.110153_bib61","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1113\/jphysiol.1993.sp019881","article-title":"Electrophysiological effects of tachykinins and capsaicin on guinea-pig bronchial parasympathetic ganglion neurones","volume":"470","author":"Myers","year":"1993","journal-title":"J Physiol (Lond)"},{"key":"10.1067\/mai.2000.110153_bib62","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1113\/jphysiol.1994.sp020388","article-title":"Evidence that antidromically stimulated vagal afferents activate inhibitory neurones innervating guinea-pig trachealis","volume":"480","author":"Canning","year":"1994","journal-title":"J Physiol (Lond)"},{"key":"10.1067\/mai.2000.110153_bib63","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1172\/JCI119763","article-title":"Pretreatment with antibody to eosinophil major basic protein prevents hyperresponsiveness by protecting neuronal M2 muscarinic receptors in antigen-challenged guinea pigs","volume":"100","author":"Evans","year":"1997","journal-title":"J Clin Invest"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674900008964?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674900008964?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T20:01:34Z","timestamp":1733169694000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674900008964"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,11]]},"references-count":63,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2000,11]]}},"alternative-id":["S0091674900008964"],"URL":"https:\/\/doi.org\/10.1067\/mai.2000.110153","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2000,11]]}}}