{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T08:24:54Z","timestamp":1770884694001,"version":"3.50.1"},"reference-count":24,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2000,11,1]],"date-time":"2000-11-01T00:00:00Z","timestamp":973036800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2000,11,1]],"date-time":"2000-11-01T00:00:00Z","timestamp":973036800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2000,11]]},"DOI":"10.1067\/mai.2000.110475","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T00:17:12Z","timestamp":1027556232000},"page":"880-886","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Kinetics of IL-10 production after segmental antigen challenge of atopic asthmatic subjects"],"prefix":"10.1067","volume":"106","author":[{"given":"Annette M.","family":"Colavita","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annette T.","family":"Hastie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali I.","family":"Musani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodolfo M.","family":"Pascual","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan J.","family":"Reinach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.Todd","family":"Lustine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve A.","family":"Galati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James G.","family":"Zangrilli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James E.","family":"Fish","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen P.","family":"Peters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1067\/mai.2000.110475_bib1","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.4049\/jimmunol.136.7.2348","article-title":"Two types of murine helper T cell clone","volume":"136","author":"Mosmann","year":"1986","journal-title":"J Immunol"},{"key":"10.1067\/mai.2000.110475_bib2","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0167-5699(87)90171-X","article-title":"Two types of mouse helper T-cell clone","volume":"8","author":"Mosmann","year":"1987","journal-title":"Immunol Today"},{"key":"10.1067\/mai.2000.110475_bib3","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1073\/pnas.88.4.1172","article-title":"Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI","volume":"88","author":"Viera","year":"1991","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1067\/mai.2000.110475_bib4","doi-asserted-by":"crossref","first-page":"353","DOI":"10.4049\/jimmunol.150.2.353","article-title":"Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production","volume":"150","author":"Del Prete","year":"1993","journal-title":"J Immunol"},{"key":"10.1067\/mai.2000.110475_bib5","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1146\/annurev.iy.11.040193.001121","article-title":"Interleukin-10","volume":"11","author":"Moore","year":"1993","journal-title":"Ann Rev Immunol"},{"key":"10.1067\/mai.2000.110475_bib6","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1749-6632.1996.tb32582.x","article-title":"Synthesis of type 1 (INF) and type 2 (IL-4, IL-5 and IL-10) cytokines by human eosinophils","volume":"796","author":"Lamkhioued","year":"1996","journal-title":"Ann N Y Acad Sci"},{"key":"10.1067\/mai.2000.110475_bib7","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/BF01543103","article-title":"Biology of human Th1 and Th2 cells","volume":"15","author":"Romagnani","year":"1995","journal-title":"J Clin Immunol"},{"key":"10.1067\/mai.2000.110475_bib8","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.4049\/jimmunol.148.4.1086","article-title":"IL-4 induces adherence of human eosinophils and basophils but not neutrophils to endothelium: association with expression of VCAM-1","volume":"148","author":"Schleimer","year":"1992","journal-title":"J Immunol"},{"key":"10.1067\/mai.2000.110475_bib9","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0272-5231(05)70265-3","article-title":"Contributing factors to the pathobiology of asthma: the TH1\/TH2 paradigm","volume":"21","author":"Colavita","year":"2000","journal-title":"Clin Chest Med"},{"key":"10.1067\/mai.2000.110475_bib10","doi-asserted-by":"crossref","first-page":"3815","DOI":"10.4049\/jimmunol.147.11.3815","article-title":"IL-10 inhibits cytokine production by activated macrophages","volume":"147","author":"Fiorentino","year":"1991","journal-title":"J Immunol"},{"key":"10.1067\/mai.2000.110475_bib11","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1084\/jem.174.5.1209","article-title":"IL-10 inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes","volume":"174","author":"de Waal Malefyt","year":"1991","journal-title":"J Exp Med"},{"key":"10.1067\/mai.2000.110475_bib12","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1084\/jem.174.4.915","article-title":"Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression","volume":"174","author":"de Waal Malefyt","year":"1991","journal-title":"J Exp Med"},{"key":"10.1067\/mai.2000.110475_bib13","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1084\/jem.180.2.711","article-title":"Interleukin 10 inhibits lipopolysaccharide-induced survival and cytokine production by human peripheral blood eosinophils","volume":"180","author":"Takanaski","year":"1994","journal-title":"J Exp Med"},{"key":"10.1067\/mai.2000.110475_bib14","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1016\/S0091-6749(96)70197-5","article-title":"Interleukin-10 regulation in normal subjects and patients with asthma","volume":"97","author":"Borish","year":"1996","journal-title":"J Allergy Clin Immunol"},{"key":"10.1067\/mai.2000.110475_bib15","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1165\/ajrcmb.14.2.8630259","article-title":"Increased interleukin-10 messenger rna expression in atopic allergy and asthma","volume":"14","author":"Robinson","year":"1996","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1067\/mai.2000.110475_bib16","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1164\/ajrccm.157.1.9703079","article-title":"Inhaled corticosteroids increase interleukin-10 but reduce macrophage inflammatory protein-1, granulocyte-macrophage colony-stimulating factor, and interferon-release from alveolar macrophages in asthma","volume":"157","author":"John","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1067\/mai.2000.110475_bib17","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1111\/j.1398-9995.1998.tb03821.x","article-title":"Alveolar macrophage interleukin (IL)-10 and IL-12 production in atopic asthma","volume":"53","author":"Magnan","year":"1998","journal-title":"Allergy"},{"key":"10.1067\/mai.2000.110475_bib18","series-title":"Guidelines for the diagnosis and management of asthma","author":"Murphy","year":"1997"},{"key":"10.1067\/mai.2000.110475_bib19","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1164\/ajrccm.152.4.7551369","article-title":"Pulmonary inflammation after segmental ragweed challenge in allergic asthmatics and nonasthmatics","volume":"152","author":"Shaver","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1067\/mai.2000.110475_bib20","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1164\/ajrccm.155.2.9032176","article-title":"Kinetics of the development and recovery of the lung from IgE-mediated inflammation","volume":"155","author":"Shaver","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1067\/mai.2000.110475_bib21","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1164\/ajrccm\/147.3.677","article-title":"Immunoglobulin E\u2013mediated increase in vascular permeability correlates with eosinophilic inflammation","volume":"147","author":"Collins","year":"1993","journal-title":"Am Rev Respir Dis"},{"key":"10.1067\/mai.2000.110475_bib22","first-page":"L401","article-title":"HSP27 elevated in mild allergic inflammation protects airway epithelium from H2SO4 effects","volume":"273","author":"Hastie","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1067\/mai.2000.110475_bib23","doi-asserted-by":"crossref","first-page":"4368","DOI":"10.4049\/jimmunol.152.9.4368","article-title":"B7\/CD28-dependent IL-5 production by human resting T cells is inhibited by IL-10","volume":"152","author":"Schandene","year":"1994","journal-title":"J Immunol"},{"key":"10.1067\/mai.2000.110475_bib24","first-page":"A923","article-title":"Attenuated production of intracellular IL-12 in monocytes from patients with severe asthma","volume":"161","author":"Tomita","year":"2000","journal-title":"Am J Respir Crit Care Med"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674900399596?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674900399596?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T04:48:36Z","timestamp":1758775716000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674900399596"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,11]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2000,11]]}},"alternative-id":["S0091674900399596"],"URL":"https:\/\/doi.org\/10.1067\/mai.2000.110475","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2000,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Kinetics of IL-10 production after segmental antigen challenge of atopic asthmatic subjects","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1067\/mai.2000.110475","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2000 Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}