{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:49:51Z","timestamp":1790250591592,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2001,11,1]],"date-time":"2001-11-01T00:00:00Z","timestamp":1004572800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2001,11,1]],"date-time":"2001-11-01T00:00:00Z","timestamp":1004572800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2001,11]]},"DOI":"10.1067\/mai.2001.118794","type":"journal-article","created":{"date-parts":[[2002,8,24]],"date-time":"2002-08-24T18:14:26Z","timestamp":1030212866000},"page":"764-771","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Requirements for allergen-induced airway inflammation and hyperreactivity in CD4-deficient and CD4-sufficient HLA-DQ transgenic mice"],"prefix":"10.1067","volume":"108","author":[{"given":"Svetlana P.","family":"Chapoval","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric V.","family":"Marietta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele K.","family":"Smart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chella S.","family":"David","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1067\/mai.2001.118794_bib1","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1164\/ajrccm\/145.6.1469","article-title":"Airway hyperresponsiveness, increased intracellular spaces of bronchial epithelium, and increased infiltration of eosinophils and lymphocytes in bronchial mucosa in asthma","volume":"145","author":"Ohashi","year":"1992","journal-title":"Am Rev Respir Dis"},{"key":"10.1067\/mai.2001.118794_bib2","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1067\/mai.2000.105712","article-title":"Mechanisms of eosinophil-associated inflammation","volume":"105","author":"Gleich","year":"2000","journal-title":"J Allergy Clin Immunol"},{"key":"10.1067\/mai.2001.118794_bib3","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1084\/jem.167.5.1737","article-title":"Highly purified murine interleukin 5 (IL-5) stimulates eosinophil function and prolongs in vitro survival. IL-5 as an eosinophil chemotactic factor","volume":"167","author":"Yamaguchi","year":"1988","journal-title":"J Exp Med"},{"key":"10.1067\/mai.2001.118794_bib4","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1084\/jem.167.1.219","article-title":"Recombinant human interleukin 5 is a selective activator of human eosinophil function","volume":"167","author":"Lopez","year":"1988","journal-title":"J Exp Med"},{"key":"10.1067\/mai.2001.118794_bib5","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1111\/j.1365-2222.1996.tb00586.x","article-title":"Mouse models of allergic disease: how do they relate to asthma in man?","volume":"26","author":"Richards","year":"1996","journal-title":"Clin Exp Allergy"},{"key":"10.1067\/mai.2001.118794_bib6","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1084\/jem.190.2.267","article-title":"T helper cell type 2 cytokine-mediated comitogenic responses and CCR3 expression during differentiation of human mast cells in vitro","volume":"190","author":"Ochi","year":"1999","journal-title":"J Exp Med"},{"key":"10.1067\/mai.2001.118794_bib7","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.4049\/jimmunol.160.5.2145","article-title":"CD40 ligand and appropriate cytokines induce switching to IgG, IgA, and IgE and coordinated germinal center and plasmacytoid phenotypic differentiation in a human monoclonal IgM+IgD+ B cell line","volume":"160","author":"Cerutti","year":"1998","journal-title":"J Immunol"},{"key":"10.1067\/mai.2001.118794_bib8","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1165\/ajrcmb.10.6.8003337","article-title":"Depletion of murine CD4+ T lymphocytes prevents antigen-induced airway hyperreactivity and pulmonary eosinophilia","volume":"10","author":"Gavett","year":"1994","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1067\/mai.2001.118794_bib9","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1006\/clin.1995.1055","article-title":"T cells are necessary for Th2 cytokine production and eosinophil accumulation in airways of antigen-challenged allergic mice","volume":"75","author":"Garlisi","year":"1995","journal-title":"Clin Immunol Immunopathol"},{"key":"10.1067\/mai.2001.118794_bib10","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1126\/science.282.5397.2261","article-title":"Requirements for IL-13 independently of IL-4 in experimental asthma","volume":"282","author":"Grunig","year":"1998","journal-title":"Science"},{"key":"10.1067\/mai.2001.118794_bib11","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1165\/ajrcmb.10.5.8179915","article-title":"Interleukin-4-dependent pulmonary eosinophil infiltration in a murine model of asthma","volume":"10","author":"Lukacs","year":"1994","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1067\/mai.2001.118794_bib12","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1172\/JCI7010","article-title":"The late, but not early, asthmatic response is dependent on IL-5 and correlates with eosinophil infiltration","volume":"104","author":"Cieslewicz","year":"1999","journal-title":"J Clinic Invest"},{"key":"10.1067\/mai.2001.118794_bib13","first-page":"L253","article-title":"Interleukin-4-receptor blockade prevents airway responses induced by antigen challenge in mice","volume":"272","author":"Gavett","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1067\/mai.2001.118794_bib14","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.4049\/jimmunol.164.2.1086","article-title":"Soluble IL-4 receptor inhibits airway inflammation following allergen challenge in mouse model of asthma","volume":"164","author":"Henderson","year":"2000","journal-title":"J Immunol"},{"key":"10.1067\/mai.2001.118794_bib15","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1084\/jem.183.1.195","article-title":"Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model","volume":"183","author":"Foster","year":"1996","journal-title":"J Exp Med"},{"key":"10.1067\/mai.2001.118794_bib16","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1172\/JCI8624","article-title":"Th2 responses induced by epicutaneous or inhalational protein exposure are differentially dependent on IL-4","volume":"105","author":"Herrick","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1067\/mai.2001.118794_bib17","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1056\/NEJM199201303260504","article-title":"Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma","volume":"326","author":"Robinson","year":"1992","journal-title":"N Engl J Med"},{"key":"10.1067\/mai.2001.118794_bib18","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S0091-6749(99)70497-5","article-title":"IL-4 and IL-5 mRNA expression in induced sputum of asthmatic subjects: comparison with bronchial wash","volume":"103","author":"Olivenstein","year":"1999","journal-title":"J Allergy Clin Immunol"},{"key":"10.1067\/mai.2001.118794_bib19","series-title":"Genetics of asthma and atopy","first-page":"4","article-title":"The heritability of allergic disease","volume":"33","author":"Dewar","year":"1996"},{"key":"10.1067\/mai.2001.118794_bib20","doi-asserted-by":"crossref","first-page":"55","DOI":"10.2500\/108854100778249042","article-title":"Genetics of asthma and allergy","volume":"21","author":"Blumenthal","year":"2000","journal-title":"Allergy Asthma Proc"},{"key":"10.1067\/mai.2001.118794_bib21","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0091-6749(00)90046-0","article-title":"Mapping susceptibility genes for asthma and allergy","volume":"105","author":"Howard","year":"2000","journal-title":"J Allergy Clin Immunol"},{"key":"10.1067\/mai.2001.118794_bib22","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1146\/annurev.immunol.18.1.347","article-title":"Molecular genetics of allergic diseases","volume":"18","author":"Ono","year":"2000","journal-title":"Annu Rev Immunol"},{"key":"10.1067\/mai.2001.118794_bib23","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1126\/science.178.4066.1201","article-title":"Ragweed hayfever: genetic control and linkage to HLA haplotypes","volume":"178","author":"Levine","year":"1972","journal-title":"Science"},{"key":"10.1067\/mai.2001.118794_bib24","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/BF00210828","article-title":"Sequencing of HLA-D in responders and nonresponders to short ragweed allergen, Amb a V","volume":"33","author":"Zwollo","year":"1991","journal-title":"Immunogenetics"},{"key":"10.1067\/mai.2001.118794_bib25","doi-asserted-by":"crossref","first-page":"411","DOI":"10.4049\/jimmunol.148.2.411","article-title":"HLA-DR2, [HLA-B7, SC31, DR2], and [HLA-B8, SC01, DR3] haplotypes distinguish subjects with asthma from those with rhinitis only in ragweed pollen allergy","volume":"148","author":"Blumenthal","year":"1992","journal-title":"J Immunol"},{"key":"10.1067\/mai.2001.118794_bib26","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0091-6749(98)70133-2","article-title":"Linkage analysis of Dermatophagoides pteronyssinus -specific IgE responsiveness with polymorphic markers on chromosome 6p21 (HLA-D region) in Caucasian families by the transmission\/disequilibrium test. Collaborative Study on the Genetics of Asthma (CSGA)","volume":"102","author":"Hizawa","year":"1998","journal-title":"J Allergy Clin Immunol"},{"key":"10.1067\/mai.2001.118794_bib27","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1034\/j.1398-9995.2000.00524.x","article-title":"Pocket 4 in the HLA-DRB1 antigen-binding groove: an association with atopy","volume":"55","author":"Torres-Galvan","year":"2000","journal-title":"Allergy"},{"key":"10.1067\/mai.2001.118794_bib28","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1084\/jem.183.1.27","article-title":"HLA-DQ8 transgenic mice are highly susceptible to collagen-induced arthritis. A novel model for human polyarthritis","volume":"183","author":"Nabozny","year":"1996","journal-title":"J Exp Med"},{"key":"10.1067\/mai.2001.118794_bib29","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1172\/JCI119760","article-title":"HLA-DQB1 polymorphism determine incidence, onset, and severity of collagen-induced arthritis (CIA) in transgenic mice: implications in human rheumatoid arthritis","volume":"100","author":"Bradley","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1067\/mai.2001.118794_bib30","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/353180a0","article-title":"Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4","volume":"353","author":"Rahemtulla","year":"1991","journal-title":"Nature"},{"key":"10.1067\/mai.2001.118794_bib31","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1002\/eji.1830240942","article-title":"Class II major histocompatibility complex-restricted T cell function in CD4-deficient mice","volume":"24","author":"Rahemtulla","year":"1994","journal-title":"Eur J Immunol"},{"key":"10.1067\/mai.2001.118794_bib32","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1084\/jem.179.4.1233","article-title":"Human CD4 restores normal T cell development and function in mice deficient in murine CD4","volume":"179","author":"Law","year":"1994","journal-title":"J Exp Med"},{"key":"10.1067\/mai.2001.118794_bib33","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1172\/JCI6175","article-title":"Short ragweed allergen induces eosinophilic lung disease in HLA-DQ transgenic mice","volume":"103","author":"Chapoval","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1067\/mai.2001.118794_bib34","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1165\/ajrcmb.18.6.3056","article-title":"Reduction of antigen-induced airway hyperreactivity and eosinophilia in ICAM-1-deficient mice","volume":"18","author":"Wolyniec","year":"1998","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1067\/mai.2001.118794_bib35","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1164\/ajrccm.156.3.9606031","article-title":"Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography","volume":"156","author":"Hamelmann","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1067\/mai.2001.118794_bib36","first-page":"4.1.1","article-title":"In vivo depletion of CD4- and CD8-specific T cells","author":"Kriusbeek","year":"1991"},{"key":"10.1067\/mai.2001.118794_bib37","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.4049\/jimmunol.142.6.1847","article-title":"Effector cell expression of NK1.1, a murine natural killer-specific molecule, and ability of mice to reject bone marrow allografts","volume":"142","author":"Sentman","year":"1989","journal-title":"J Immunol"},{"key":"10.1067\/mai.2001.118794_bib38","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.4049\/jimmunol.161.4.2032","article-title":"HLA-DQ6 and HLA-DQ8 transgenic mice respond to ragweed allergen and recognize distinct set of epitopes on short and giant ragweed group 5 antigens","volume":"161","author":"Chapoval","year":"1998","journal-title":"J Immunol"},{"key":"10.1067\/mai.2001.118794_bib39","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1084\/jem.186.3.343","article-title":"Complexity and redundancy in the pathogenesis of asthma: reassessing the roles of mast cells and T cells","volume":"186","author":"Galli","year":"1997","journal-title":"J Exp Med"},{"key":"10.1067\/mai.2001.118794_bib40","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1067\/mai.2000.106485","article-title":"The diverse potential effector and immunoregulatory roles of mast cells in allergic disease","volume":"105","author":"Williams","year":"2000","journal-title":"J Allergy Clin Immunol"},{"key":"10.1067\/mai.2001.118794_bib41","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1084\/jem.186.3.449","article-title":"Development of eosinophilic airway inflammation and airway hyperresponsiveness in mast cell-deficient mice","volume":"186","author":"Takeda","year":"1997","journal-title":"J Exp Med"},{"key":"10.1067\/mai.2001.118794_bib42","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1126\/science.287.5460.2013","article-title":"Prostaglandin D2 as a mediator of allergic asthma","volume":"287","author":"Matsuoka","year":"2000","journal-title":"Science"},{"key":"10.1067\/mai.2001.118794_bib43","doi-asserted-by":"crossref","first-page":"3855","DOI":"10.4049\/jimmunol.164.7.3855","article-title":"An essential role of mast cells in the development of airway hyperresponsiveness in a murine asthma model","volume":"164","author":"Kobayashi","year":"2000","journal-title":"J Immunol"},{"key":"10.1067\/mai.2001.118794_bib44","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1084\/jem.192.3.455","article-title":"Mast cells can amplify airway reactivity and features of chronic inflammation in an asthma model in mice","volume":"192","author":"Williams","year":"2000","journal-title":"J Exp Med"},{"key":"10.1067\/mai.2001.118794_bib45","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1159\/000237362","article-title":"Induction of histamine release from non-immunized guinea pigs: a possible involvement of lectin-like factor(s) in pollinosis","volume":"111","author":"Imamura","year":"1996","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1067\/mai.2001.118794_bib46","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0091-6749(99)70538-5","article-title":"IgE-binding and histamine-release capabilities of the main carbohydrate component isolated from the major allergen of olive tree pollen, Ole e 1","volume":"103","author":"Batanero","year":"1999","journal-title":"J Allergy Clin Immunol"},{"key":"10.1067\/mai.2001.118794_bib47","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1002\/eji.1830260518","article-title":"Human CD4 and human major histocompatibility complex class II (DQ6) transgenic mice: supersensitivity to superantigen-induced septic shock","volume":"26","author":"Yeung","year":"1996","journal-title":"Eur J Immunol"},{"key":"10.1067\/mai.2001.118794_bib48","doi-asserted-by":"crossref","first-page":"7821","DOI":"10.1073\/pnas.93.15.7821","article-title":"Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung: lymphocytic and eosinophilic inflammation without airway eosinophilia","volume":"93","author":"Rankin","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1067\/mai.2001.118794_bib49","doi-asserted-by":"crossref","first-page":"6007","DOI":"10.1073\/pnas.100118997","article-title":"IL-10 is necessary for the expression of airway hyperresponsiveness but not pulmonary inflammation after allergic sensitization","volume":"97","author":"Makela","year":"2000","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674901175172?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674901175172?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T04:47:27Z","timestamp":1758775647000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674901175172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,11]]},"references-count":49,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2001,11]]}},"alternative-id":["S0091674901175172"],"URL":"https:\/\/doi.org\/10.1067\/mai.2001.118794","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2001,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Requirements for allergen-induced airway inflammation and hyperreactivity in CD4-deficient and CD4-sufficient HLA-DQ transgenic mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1067\/mai.2001.118794","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2001 Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}